A Novel Cannabinoid Peripheral Cannabinoid Receptor-Selective Inverse Agonist Blocks Leukocyte Recruitment in Vivo
Lunn, Charles A, Fine, Jay S, Rojas-Triana, Alberto, Jackson, James V, Fan, Xuedong, Kung, Ted T, Gonsiorek, Waldemar, Schwarz, Martin A, Lavey, Brian, Kozlowski, Joseph A, Narula, Satwant K, Lundell, Daniel J, Hipkin, R William, Bober, Loretta A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2006)
Get full text
Journal Article
Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice
Reich, Eva‐Pia, Cui, Long, Yang, Lily, Pugliese‐Sivo, Catherine, Golovko, Andrei, Petro, Mary, Vassileva, Galya, Chu, Inhou, Nomeir, Amin A., Zhang, Li‐Kang, Liang, Xian, Kozlowski, Joseph A., Narula, Satwant K., Zavodny, Paul J., Chou, Chuan‐Chu
Published in European journal of immunology (01.04.2005)
Published in European journal of immunology (01.04.2005)
Get full text
Journal Article
Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands
Tong, Ling, Shankar, B.B., Chen, Lei, Rizvi, Razia, Kelly, Joseph, Gilbert, Eric, Huang, Chunli, Yang, De-Yi, Kozlowski, Joseph A., Shih, N.-Y., Gonsiorek, W., Hipkin, R. William, Malikzay, Asra, Lunn, Charles A., Lundell, Daniel J.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Get full text
Journal Article
Discovery of novel pan-genotypic HCV NS5A inhibitors containing a novel tetracyclic core
Yu, Wensheng, Hu, Bin, Zhong, Bin, Hao, Jinglai, Lei, Zhixin, Agrawal, Sony, Rokosz, Laura, Liu, Rong, Chen, Shiying, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.03.2019)
Published in Bioorganic & medicinal chemistry letters (01.03.2019)
Get full text
Journal Article
Characterization of Peripheral Human Cannabinoid Receptor (hCB2) Expression and Pharmacology Using a Novel Radioligand, [35S]Sch225336
Gonsiorek, Waldemar, Hesk, David, Chen, Shu-Cheng, Kinsley, David, Fine, Jay S., Jackson, James V., Bober, Loretta A., Deno, Gregory, Bian, Hong, Fossetta, James, Lunn, Charles A., Kozlowski, Joseph A., Lavey, Brian, Piwinski, John, Narula, Satwant K., Lundell, Daniel J., Hipkin, R. William
Published in The Journal of biological chemistry (22.09.2006)
Published in The Journal of biological chemistry (22.09.2006)
Get full text
Journal Article
Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms
Tong, Ling, Yu, Wensheng, Chen, Lei, Selyutin, Oleg, Dwyer, Michael P, Nair, Anilkumar G, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Yin, Jingjun, Ruck, Rebecca T, Davies, Ian W, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Liu, Rong, Agrawal, Sony, Xia, Ellen, Curry, Stephanie, McMonagle, Patricia, Bystol, Karin, Lahser, Frederick, Carr, Donna, Rokosz, Laura, Ingravallo, Paul, Chen, Shiying, Feng, Kung-I, Cartwright, Mark, Asante-Appiah, Ernest, Kozlowski, Joseph A
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
Get full text
Journal Article
Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2‑Substituted Benzamide Zinc Binding Group
Liu, Jian, Yu, Younong, Kelly, Joseph, Sha, Deyou, Alhassan, Abdul-Basit, Yu, Wensheng, Maletic, Milana M, Duffy, Joseph L, Klein, Daniel J, Holloway, M. Katharine, Carroll, Steve, Howell, Bonnie J, Barnard, Richard J. O, Wolkenberg, Scott, Kozlowski, Joseph A
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
Get full text
Journal Article
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes
Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Babu Boga, Sobhana, Alhassan, Abdul-Basit, Yu, Wensheng, Selyutin, Oleg, Yu, Younong, Anand, Rajan, Xu, Jiayi, Kelly, Joseph, Duffy, Joseph L., Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Bennett, Chad, Maloney, Kevin M., Tyagarajan, Sriram, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Get full text
Journal Article
Discovery of Chromane Containing Hepatitis C Virus (HCV) NS5A Inhibitors with Improved Potency against Resistance-Associated Variants
Yu, Wensheng, Tong, Ling, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Coburn, Craig A, Selyutin, Oleg, Chen, Lei, Rokosz, Laura, Agrawal, Sony, Liu, Rong, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Asante-Appiah, Ernest, Chen, Shiying, Kozlowski, Joseph A
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
Get full text
Journal Article
Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions
Yu, Wensheng, Tong, Ling, Selyutin, Oleg, Chen, Lei, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Yin, Jingjun, Ruck, Rebecca T, Curry, Stephanie, McMonagle, Patricia, Agrawal, Sony, Rokosz, Laura, Carr, Donna, Ingravallo, Paul, Bystol, Karin, Lahser, Frederick, Liu, Rong, Chen, Shiying, Feng, Kung-I, Cartwright, Mark, Asante-Appiah, Ernest, Kozlowski, Joseph A
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
Get full text
Journal Article
Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV‑1 Protein for Clearance
Liu, Jian, Kelly, Joseph, Yu, Wensheng, Clausen, Dane, Yu, Younong, Kim, Hyunjin, Duffy, Joseph L, Chung, Christine C, Myers, Robert W, Carroll, Steve, Klein, Daniel J, Fells, James, Holloway, M. Katharine, Wu, Jin, Wu, Guoxin, Howell, Bonnie J, Barnard, Richard J. O, Kozlowski, Joseph A
Published in ACS medicinal chemistry letters (09.07.2020)
Published in ACS medicinal chemistry letters (09.07.2020)
Get full text
Journal Article
Synthesis of HDAC Inhibitor Libraries via Microscale Workflow
Dykstra, Kevin D, Streckfuss, Eric, Liu, Min, Liu, Jian, Yu, Younong, Wang, Ming, Kozlowski, Joseph A, Myers, Robert W, Buevich, Alexei V, Maletic, Milana M, Vachal, Petr, Krska, Shane W
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
Get full text
Journal Article
Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors
Tong, Ling, Kim, Seong Heon, Rosner, Kristin, Yu, Wensheng, Shankar, Bandarpalle B., Chen, Lei, Li, Dansu, Dai, Chaoyang, Girijavallabhan, Vinay, Popovici-Muller, Janeta, Yang, Liping, Zhou, Guowei, Kosinski, Aneta, Siddiqui, M. Arshad, Shih, Neng-Yang, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Lundell, Daniel, Niu, Xiaoda, Umland, Shelby, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.07.2017)
Published in Bioorganic & medicinal chemistry letters (15.07.2017)
Get full text
Journal Article
Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors
Tong, Ling, Yu, Wensheng, Coburn, Craig A., Meinke, Peter T., Nair, Anilkumar G., Dwyer, Michael P., Chen, Lei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Fells, James, Hu, Bin, Zhong, Bin, Soll, Richard M., Liu, Rong, Agrawal, Sony, Xia, Ellen, Zhai, Ying, Kong, Rong, Ingravallo, Paul, Nomeir, Amin, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Get full text
Journal Article
MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV
Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael, Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Get full text
Journal Article
Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development
Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael P., Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Allard, Melissa L., Buckle, Ronald N., Gauuan, Polivina Jolicia F., Holst, Christian L., Martin, Gregory S., Naicker, Kannan P., Vellekoop, Samuel, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Get full text
Journal Article
Development of a prodrug of hydantoin based TACE inhibitor
Tong, Ling, Kim, Seong Heon, Chen, Lei, Kosinski, Aneta, Shankar, Bandarpalle B., Girijavallabhan, Vinay, Yang, De-Yi, Yu, Wensheng, Zhou, Guowei, Shih, Neng-Yang, Chen, Shiying, Hu, Mengwei, Lundell, Daniel, Niu, Xiaoda, Umland, Shelby, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Get full text
Journal Article
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis
Boga, Sobhana Babu, Alhassan, Abdul-Basit, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Zhu, Hugh, Desai, Jagdish, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Cooper, Alan, Kim, Ronald M., Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Get full text
Journal Article
Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors
Velázquez, Francisco, Venkatraman, Srikanth, Lesburg, Charles A, Duca, José, Rosenblum, Stuart B, Kozlowski, Joseph A, Njoroge, F. George
Published in Organic letters (20.01.2012)
Published in Organic letters (20.01.2012)
Get full text
Journal Article
Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742
Yu, Wensheng, Zhou, Guowei, Coburn, Craig A., Zeng, Qingbei, Tong, Ling, Dwyer, Michael P., Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Chen, Lei, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Selyutin, Oleg, Rosenblum, Stuart B., Lavey, Brian, Nair, Anilkumar G., Heon Kim, Seong, Keertikar, Kerry M., Rokosz, Laura, Agrawal, Sony, Liu, Rong, Xia, Ellen, Zhai, Ying, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Asante-Appiah, Ernest, Chen, Shiying, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Get full text
Journal Article