New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p -Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment
Makhaeva, Galina F, Kovaleva, Nadezhda V, Boltneva, Natalia P, Lushchekina, Sofya V, Astakhova, Tatiana Yu, Rudakova, Elena V, Proshin, Alexey N, Serkov, Igor V, Radchenko, Eugene V, Palyulin, Vladimir A, Bachurin, Sergey O, Richardson, Rudy J
Published in Molecules (Basel, Switzerland) (27.08.2020)
Published in Molecules (Basel, Switzerland) (27.08.2020)
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Journal Article
New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment
Makhaeva, Galina F, Kovaleva, Nadezhda V, Rudakova, Elena V, Boltneva, Natalia P, Lushchekina, Sofya V, Faingold, Irina I, Poletaeva, Darya A, Soldatova, Yuliya V, Kotelnikova, Raisa A, Serkov, Igor V, Ustinov, Anatoly K, Proshin, Alexey N, Radchenko, Eugene V, Palyulin, Vladimir A, Richardson, Rudy J
Published in Molecules (Basel, Switzerland) (12.12.2020)
Published in Molecules (Basel, Switzerland) (12.12.2020)
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Journal Article
Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N -Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile
Makhaeva, Galina F, Kovaleva, Nadezhda V, Boltneva, Natalia P, Rudakova, Elena V, Lushchekina, Sofya V, Astakhova, Tatiana Yu, Serkov, Igor V, Proshin, Alexey N, Radchenko, Eugene V, Palyulin, Vladimir A, Korabecny, Jan, Soukup, Ondrej, Bachurin, Sergey O, Richardson, Rudy J
Published in Molecules (Basel, Switzerland) (04.02.2022)
Published in Molecules (Basel, Switzerland) (04.02.2022)
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Journal Article
Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease
Makhaeva, Galina F, Kovaleva, Nadezhda V, Rudakova, Elena V, Boltneva, Natalia P, Lushchekina, Sofya V, Astakhova, Tatiana Y, Timokhina, Elena N, Serkov, Igor V, Proshin, Alexey N, Soldatova, Yuliya V, Poletaeva, Darya A, Faingold, Irina I, Mumyatova, Viktoriya A, Terentiev, Alexey A, Radchenko, Eugene V, Palyulin, Vladimir A, Bachurin, Sergey O, Richardson, Rudy J
Published in Molecules (Basel, Switzerland) (01.01.2024)
Published in Molecules (Basel, Switzerland) (01.01.2024)
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Journal Article
Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity
Burgart, Yanina V, Makhaeva, Galina F, Krasnykh, Olga P, Borisevich, Sophia S, Agafonova, Natalia A, Kovaleva, Nadezhda V, Boltneva, Natalia P, Rudakova, Elena V, Shchegolkov, Evgeny V, Triandafilova, Galina A, Gazizov, Denis A, Serebryakova, Olga G, Ulitko, Maria V, Khursan, Sergey L, Saloutin, Victor I, Richardson, Rudy J
Published in Molecules (Basel, Switzerland) (01.11.2022)
Published in Molecules (Basel, Switzerland) (01.11.2022)
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Journal Article
Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease
Bachurin, Sergey O, Shevtsova, Elena F, Makhaeva, Galina F, Aksinenko, Alexey Yu, Grigoriev, Vladimir V, Goreva, Tatiana V, Epishina, Tatiana A, Kovaleva, Nadezhda V, Boltneva, Natalia P, Lushchekina, Sofya V, Rudakova, Elena V, Vinogradova, Darya V, Shevtsov, Pavel N, Pushkareva, Elena A, Dubova, Ludmila G, Serkova, Tatiana P, Veselov, Ivan M, Fisenko, Vladimir P, Richardson, Rudy J
Published in International journal of molecular sciences (11.11.2022)
Published in International journal of molecular sciences (11.11.2022)
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Journal Article
Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease
Makhaeva, Galina F., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Lushchekina, Sofya V., Astakhova, Tatiana Yu, Timokhina, Elena N., Serebryakova, Olga G., Shchepochkin, Alexander V., Averkov, Maxim A., Utepova, Irina A., Demina, Nadezhda S., Radchenko, Eugene V., Palyulin, Vladimir A., Fisenko, Vladimir P., Bachurin, Sergey O., Chupakhin, Oleg N., Charushin, Valery N., Richardson, Rudy J.
Published in Frontiers in pharmacology (09.08.2023)
Published in Frontiers in pharmacology (09.08.2023)
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Journal Article
Overview of novel multifunctional agents based on conjugates of γ-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease
Makhaeva, Galina F., Shevtsova, Elena F., Boltneva, Natalia P., Lushchekina, Sofya V., Kovaleva, Nadezhda V., Rudakova, Elena V., Bachurin, Sergey O., Richardson, Rudy J.
Published in Chemico-biological interactions (01.08.2019)
Published in Chemico-biological interactions (01.08.2019)
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Journal Article
Annulated bicyclic isothioureas: identification of active and selective butyrylcholinesterase inhibitors
Nurieva, Evgeniya V., Alexeev, Alexander A., Zefirov, Nikolay A., Milaeva, Elena R., Kovaleva, Nadezhda V., Proshin, Alexey N., Makhaeva, Galina F., Zefirova, Olga N.
Published in Mendeleev communications (01.01.2023)
Published in Mendeleev communications (01.01.2023)
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Journal Article
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
Bachurin, Sergey O, Shevtsova, Elena F, Makhaeva, Galina F, Grigoriev, Vladimir V, Boltneva, Natalia P, Kovaleva, Nadezhda V, Lushchekina, Sofya V, Shevtsov, Pavel N, Neganova, Margarita E, Redkozubova, Olga M, Bovina, Elena V, Gabrelyan, Alexey V, Fisenko, Vladimir P, Sokolov, Vladimir B, Aksinenko, Alexey Yu, Echeverria, Valentina, Barreto, George E, Aliev, Gjumrakch
Published in Scientific reports (30.03.2017)
Published in Scientific reports (30.03.2017)
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Journal Article
Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer’s disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation
Makhaeva, Galina F., Kovaleva, Nadezhda V., Boltneva, Natalia P., Lushchekina, Sofya V., Rudakova, Elena V., Stupina, Tatyana S., Terentiev, Alexey A., Serkov, Igor V., Proshin, Alexey N., Radchenko, Eugene V., Palyulin, Vladimir A., Bachurin, Sergey O., Richardson, Rudy J.
Published in Bioorganic chemistry (01.01.2020)
Published in Bioorganic chemistry (01.01.2020)
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Journal Article
Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold
Makhaeva, Galina F., Lushchekina, Sofya V., Boltneva, Natalia P., Serebryakova, Olga G., Kovaleva, Nadezhda V., Rudakova, Elena V., Elkina, Natalia A., Shchegolkov, Evgeny V., Burgart, Yanina V., Stupina, Tatyana S., Terentiev, Alexey A., Radchenko, Eugene V., Palyulin, Vladimir A., Saloutin, Victor I., Bachurin, Sergey O., Richardson, Rudy J.
Published in European journal of medicinal chemistry (05.06.2021)
Published in European journal of medicinal chemistry (05.06.2021)
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Journal Article
Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment
Makhaeva, Galina F., Lushchekina, Sofya V., Kovaleva, Nadezhda V., Yu. Astakhova, Tatiana, Boltneva, Natalia P., Rudakova, Elena V., Serebryakova, Olga G., Proshin, Alexey N., Serkov, Igor V., Trofimova, Tatiana P., Tafeenko, Victor A., Radchenko, Eugene V., Palyulin, Vladimir A., Fisenko, Vladimir P., Korábečný, Jan, Soukup, Ondrej, Richardson, Rudy J.
Published in Bioorganic chemistry (01.07.2021)
Published in Bioorganic chemistry (01.07.2021)
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Journal Article
Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease
Makhaeva, Galina F, Kovaleva, Nadezhda V, Rudakova, Elena V, Boltneva, Natalia P, Grishchenko, Maria V, Lushchekina, Sofya V, Astakhova, Tatiana Y, Serebryakova, Olga G, Timokhina, Elena N, Zhilina, Ekaterina F, Shchegolkov, Evgeny V, Ulitko, Mariya V, Radchenko, Eugene V, Palyulin, Vladimir A, Burgart, Yanina V, Saloutin, Victor I, Bachurin, Sergey O, Richardson, Rudy J
Published in International journal of molecular sciences (24.01.2023)
Published in International journal of molecular sciences (24.01.2023)
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Journal Article
Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease
Grishchenko, Maria V., Makhaeva, Galina F., Burgart, Yanina V., Rudakova, Elena V., Boltneva, Natalia P., Kovaleva, Nadezhda V., Serebryakova, Olga G., Lushchekina, Sofya V., Astakhova, Tatiana Y., Zhilina, Ekaterina F., Shchegolkov, Evgeny V., Richardson, Rudy J., Saloutin, Victor I.
Published in ChemMedChem (18.05.2022)
Published in ChemMedChem (18.05.2022)
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Journal Article
Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block β‐amyloid aggregation
Khudina, Olga G., Grishchenko, Maria V., Makhaeva, Galina F., Kovaleva, Nadezhda V., Boltneva, Natalia P., Rudakova, Elena V., Lushchekina, Sofya V., Shchegolkov, Evgeny V., Borisevich, Sophia S., Burgart, Yanina V., Saloutin, Victor I., Charushin, Valery N.
Published in Archiv der Pharmazie (Weinheim) (01.02.2024)
Published in Archiv der Pharmazie (Weinheim) (01.02.2024)
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Journal Article
Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands
Bachurin, Sergey O., Makhaeva, Galina F., Shevtsova, Elena F., Aksinenko, Alexey Yu, Grigoriev, Vladimir V., Shevtsov, Pavel N., Goreva, Tatiana V., Epishina, Tatiana A., Kovaleva, Nadezhda V., Pushkareva, Elena A., Boltneva, Natalia P., Lushchekina, Sofya V., Gabrelyan, Alexey V., Zamoyski, Vladimir L., Dubova, Lyudmila G., Rudakova, Elena V., Fisenko, Vladimir P., Bovina, Elena V., Richardson, Rudy J.
Published in Molecules (Basel, Switzerland) (11.09.2021)
Published in Molecules (Basel, Switzerland) (11.09.2021)
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Journal Article
Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases
Bachurin, Sergey O, Makhaeva, Galina F, Shevtsova, Elena F, Boltneva, Natalia P, Kovaleva, Nadezhda V, Lushchekina, Sofya V, Rudakova, Elena V, Dubova, Ludmila G, Vinogradova, Daria V, Sokolov, Vladimir B, Aksinenko, Alexey Yu, Fisenko, Vladimir P, Richardson, Rudy J, Aliev, Gjumrakch
Published in Scientific reports (19.03.2019)
Published in Scientific reports (19.03.2019)
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Journal Article
Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals
Burgart, Yanina V, Elkina, Natalia A, Shchegolkov, Evgeny V, Krasnykh, Olga P, Makhaeva, Galina F, Triandafilova, Galina A, Solodnikov, Sergey Yu, Boltneva, Natalia P, Rudakova, Elena V, Kovaleva, Nadezhda V, Serebryakova, Olga G, Ulitko, Mariya V, Borisevich, Sophia S, Gerasimova, Natalia A, Evstigneeva, Natalia P, Kozlov, Sergey A, Korolkova, Yuliya V, Minin, Artem S, Belousova, Anna V, Mozhaitsev, Evgenii S, Klabukov, Artem M, Saloutin, Victor I
Published in Molecules (Basel, Switzerland) (21.12.2022)
Published in Molecules (Basel, Switzerland) (21.12.2022)
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Journal Article
Focused design of polypharmacophoric neuroprotective compounds: Conjugates of γ-carbolines with carbazole derivatives and tetrahydrocarbazole
Makhaeva, Galina F., Sokolov, Vladimir B., Shevtsova, Elena F., Kovaleva, Nadezhda V., Lushchekina, Sofya V., Boltneva, Natalia P., Rudakova, Elena V., Aksinenko, Alexey Yu, Shevtsov, Pavel N., Neganova, Margarita E., Dubova, Ludmila G., Bachurin, Sergey O.
Published in Pure and applied chemistry (01.08.2017)
Published in Pure and applied chemistry (01.08.2017)
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Journal Article