Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out
Loupe, Jacob M, Pinto, Ricardo Mouro, Kim, Kyung-Hee, Gillis, Tammy, Mysore, Jayalakshmi S, Andrew, Marissa A, Kovalenko, Marina, Murtha, Ryan, Seong, IhnSik, Gusella, James F, Kwak, Seung, Howland, David, Lee, Ramee, Lee, Jong-Min, Wheeler, Vanessa C, MacDonald, Marcy E
Published in Human molecular genetics (04.11.2020)
Published in Human molecular genetics (04.11.2020)
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CAG repeat expansion in the Huntington’s disease gene shapes linear and circular RNAs biogenesis
Ayyildiz, Dilara, Bergonzoni, Guendalina, Monziani, Alan, Tripathi, Takshashila, Döring, Jessica, Kerschbamer, Emanuela, Di Leva, Francesca, Pennati, Elia, Donini, Luisa, Kovalenko, Marina, Zasso, Jacopo, Conti, Luciano, Wheeler, Vanessa C, Dieterich, Christoph, Piazza, Silvano, Dassi, Erik, Biagioli, Marta
Published in PLoS genetics (13.10.2023)
Published in PLoS genetics (13.10.2023)
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Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat
McLean, Zachariah L, Gao, Dadi, Correia, Kevin, Roy, Jennie C L, Shibata, Shota, Farnum, Iris N, Valdepenas-Mellor, Zoe, Kovalenko, Marina, Rapuru, Manasa, Morini, Elisabetta, Ruliera, Jayla, Gillis, Tammy, Lucente, Diane, Kleinstiver, Benjamin P, Lee, Jong-Min, MacDonald, Marcy E, Wheeler, Vanessa C, Mouro Pinto, Ricardo, Gusella, James F
Published in Nature communications (12.04.2024)
Published in Nature communications (12.04.2024)
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Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice
Kovalenko, Marina, Dragileva, Ella, St Claire, Jason, Gillis, Tammy, Guide, Jolene R, New, Jaclyn, Dong, Hualing, Kucherlapati, Raju, Kucherlapati, Melanie H, Ehrlich, Michelle E, Lee, Jong-Min, Wheeler, Vanessa C
Published in PloS one (07.09.2012)
Published in PloS one (07.09.2012)
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Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice
Kovalenko, Marina, Erdin, Serkan, Andrew, Marissa A, St Claire, Jason, Shaughnessey, Melissa, Hubert, Leroy, Neto, João Luís, Stortchevoi, Alexei, Fass, Daniel M, Mouro Pinto, Ricardo, Haggarty, Stephen J, Wilson, John H, Talkowski, Michael E, Wheeler, Vanessa C
Published in eLife (29.09.2020)
Published in eLife (29.09.2020)
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A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice
Hölter, Sabine M, Stromberg, Mary, Kovalenko, Marina, Garrett, Lillian, Glasl, Lisa, Lopez, Edith, Guide, Jolene, Götz, Alexander, Hans, Wolfgang, Becker, Lore, Rathkolb, Birgit, Rozman, Jan, Schrewed, Anja, Klingenspor, Martin, Klopstock, Thomas, Schulz, Holger, Wolf, Eckhard, Wursta, Wolfgang, Gillis, Tammy, Wakimoto, Hiroko, Seidman, Jonathan, MacDonald, Marcy E, Cotman, Susan, Gailus-Durner, Valérie, Fuchs, Helmut, de Angelis, Martin Hrabě, Lee, Jong-Min, Wheeler, Vanessa C
Published in PloS one (22.11.2013)
Published in PloS one (22.11.2013)
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Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection
Roy, Jennie C L, Vitalo, Antonia, Andrew, Marissa A, Mota-Silva, Eduarda, Kovalenko, Marina, Burch, Zoe, Nhu, Anh M, Cohen, Paula E, Grabczyk, Ed, Wheeler, Vanessa C, Mouro Pinto, Ricardo
Published in Nucleic acids research (19.04.2021)
Published in Nucleic acids research (19.04.2021)
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CircHTT(2,3,4,5,6) — co-evolving with the HTT CAG-repeat tract — modulates Huntington's disease phenotypes
Morandell, Jasmin, Monziani, Alan, Lazioli, Martina, Donzel, Deborah, Döring, Jessica, Oss Pegorar, Claudio, D’Anzi, Angela, Pellegrini, Miguel, Mattiello, Andrea, Bortolotti, Dalia, Bergonzoni, Guendalina, Tripathi, Takshashila, Mattis, Virginia B., Kovalenko, Marina, Rosati, Jessica, Dieterich, Christoph, Dassi, Erik, Wheeler, Vanessa C., Ellederová, Zdenka, Wilusz, Jeremy E., Viero, Gabriella, Biagioli, Marta
Published in Molecular therapy. Nucleic acids (10.09.2024)
Published in Molecular therapy. Nucleic acids (10.09.2024)
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Insulin- and Glucose-Induced Phosphorylation of the Na+,K+-Adenosine Triphosphatase α-Subunits in Rat Skeletal Muscle
Chibalin, Alexander V, Kovalenko, Marina V, Ryder, Jeffrey W, Féraille, Eric, Wallberg-Henriksson, Harriet, Zierath, Juleen R
Published in Endocrinology (Philadelphia) (01.08.2001)
Published in Endocrinology (Philadelphia) (01.08.2001)
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High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds
Ament, Seth A, Pearl, Jocelynn R, Grindeland, Andrea, St Claire, Jason, Earls, John C, Kovalenko, Marina, Gillis, Tammy, Mysore, Jayalakshmi, Gusella, James F, Lee, Jong-Min, Kwak, Seung, Howland, David, Lee, Min Young, Baxter, David, Scherler, Kelsey, Wang, Kai, Geman, Donald, Carroll, Jeffrey B, MacDonald, Marcy E, Carlson, George, Wheeler, Vanessa C, Price, Nathan D, Hood, Leroy E
Published in Human molecular genetics (01.03.2017)
Published in Human molecular genetics (01.03.2017)
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B1 HTT CAG knock-in mice with pure and interrupted repeat tracts provide insight into the role of somatic expansion in HD pathogenesis
Wheeler, Vanessa C, Kovalenko, Marina, Giordano, James, Andrew, Marissa, Menalled, Liliana, Alexandrov, Vadim, Thiede, Christina, Weidner, Jenny, Teichmann, Kerstin, Tottey, William, Cumming, Sarah A, Correia, Kevin, Barker, Douglas, Lager, Brenda, Flynn, Geraldine, Fischer, David F, Tillack, Karsten, Monckton, Darren G, Brunner, Dani, Ramboz, Sylvie, Kwak, Seung, Howland, David
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2016)
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2016)
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HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction
Kovalenko, Marina, Milnerwood, Austen, Giordano, James, St Claire, Jason, Guide, Jolene R, Stromberg, Mary, Gillis, Tammy, Sapp, Ellen, DiFiglia, Marian, MacDonald, Marcy E, Carroll, Jeffrey B, Lee, Jong-Min, Tappan, Susan, Raymond, Lynn, Wheeler, Vanessa C
Published in Journal of Huntington's disease (01.01.2018)
Published in Journal of Huntington's disease (01.01.2018)
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Chromosome substitution strain assessment of a Huntington’s disease modifier locus
Ramos, Eliana Marisa, Kovalenko, Marina, Guide, Jolene R., St. Claire, Jason, Gillis, Tammy, Mysore, Jayalakshmi S., Sequeiros, Jorge, Wheeler, Vanessa C., Alonso, Isabel, MacDonald, Marcy E.
Published in Mammalian genome (01.04.2015)
Published in Mammalian genome (01.04.2015)
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