Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases
Calvier, Laurent, Drelich, Aleksandra, Hsu, Jason, Tseng, Chien-Te, Mina, Yair, Nath, Avindra, Kounnas, Maria Z, Herz, Joachim
Published in Frontiers in immunology (27.06.2023)
Published in Frontiers in immunology (27.06.2023)
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Journal Article
Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines
Pontecorvi, Paola, Banki, Michael A, Zampieri, Carlotta, Zalfa, Cristina, Azmoon, Pardis, Kounnas, Maria Z, Marchese, Cinzia, Gonias, Steven L, Mantuano, Elisabetta
Published in Journal of neuroinflammation (06.12.2019)
Published in Journal of neuroinflammation (06.12.2019)
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Journal Article
Safety of Anti-Reelin Therapeutic Approaches for Chronic Inflammatory Diseases
Calvier, Laurent, Alexander, Anna, Marckx, Austin T, Kounnas, Maria Z, Durakoglugil, Murat, Herz, Joachim
Published in Cells (Basel, Switzerland) (01.04.2024)
Published in Cells (Basel, Switzerland) (01.04.2024)
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Journal Article
Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism
Vetrivel, Kulandaivelu S, Gong, Ping, Bowen, James W, Cheng, Haipeng, Chen, Ying, Carter, Meghan, Nguyen, Phuong D, Placanica, Lisa, Wieland, Felix T, Li, Yue-Ming, Kounnas, Maria Z, Thinakaran, Gopal
Published in Molecular neurodegeneration (08.02.2007)
Published in Molecular neurodegeneration (08.02.2007)
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Journal Article
Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes
Calvier, Laurent, Xian, Xunde, Lee, Richard G., Sacharidou, Anastasia, Mineo, Chieko, Shaul, Philip W., Kounnas, Maria Z., Tsai, Shirling, Herz, Joachim
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2021)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2021)
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Journal Article
Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease
Kounnas, Maria Z., Danks, Anne M., Cheng, Soan, Tyree, Curtis, Ackerman, Elizabeth, Zhang, Xulun, Ahn, Kwangwook, Nguyen, Phuong, Comer, Dan, Mao, Long, Yu, Chengzhi, Pleynet, David, Digregorio, Paul J., Velicelebi, Gonul, Stauderman, Kenneth A., Comer, William T., Mobley, William C., Li, Yue-Ming, Sisodia, Sangram S., Tanzi, Rudolph E., Wagner, Steven L.
Published in Neuron (Cambridge, Mass.) (09.09.2010)
Published in Neuron (Cambridge, Mass.) (09.09.2010)
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Journal Article
Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes
Calvier, Laurent, Demuth, Guillaume, Manouchehri, Navid, Wong, Connie, Sacharidou, Anastasia, Mineo, Chieko, Shaul, Philip W, Monson, Nancy L, Kounnas, Maria Z, Stüve, Olaf, Herz, Joachim
Published in Science translational medicine (12.08.2020)
Published in Science translational medicine (12.08.2020)
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Journal Article
Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts
Vetrivel, Kulandaivelu S., Meckler, Xavier, Chen, Ying, Nguyen, Phuong D., Seidah, Nabil G., Vassar, Robert, Wong, Philip C., Fukata, Masaki, Kounnas, Maria Z., Thinakaran, Gopal
Published in The Journal of biological chemistry (06.02.2009)
Published in The Journal of biological chemistry (06.02.2009)
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Journal Article
NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease
Varvel, Nicholas H, Bhaskar, Kiran, Kounnas, Maria Z, Wagner, Steven L, Yang, Yan, Lamb, Bruce T, Herrup, Karl
Published in The Journal of clinical investigation (01.12.2009)
Published in The Journal of clinical investigation (01.12.2009)
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Journal Article
Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis
Calvier, Laurent, Manouchehri, Navid, Sacharidou, Anastasia, Mineo, Chieko, Shaul, Philip W, Hui, David Y, Kounnas, Maria Z, Stüve, Olaf, Herz, Joachim
Published in Science immunology (27.08.2021)
Published in Science immunology (27.08.2021)
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Journal Article
NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ42, in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents
Kounnas, Maria Z, Lane-Donovan, Courtney, Nowakowski, Dan W, Herz, Joachim, Comer, William T
Published in Alzheimer's & dementia : translational research & clinical interventions (01.01.2017)
Published in Alzheimer's & dementia : translational research & clinical interventions (01.01.2017)
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Journal Article
NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses
Kounnas, Maria Z., Durakoglugil, Murat S., Herz, Joachim, Comer, William T.
Published in Alzheimer's & dementia : translational research & clinical interventions (2019)
Published in Alzheimer's & dementia : translational research & clinical interventions (2019)
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Journal Article
S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1
Cheng, Haipeng, Vetrivel, Kulandaivelu S., Drisdel, Renaldo C., Meckler, Xavier, Gong, Ping, Leem, Jae Yoon, Li, Tong, Carter, Meghan, Chen, Ying, Nguyen, Phuong, Iwatsubo, Takeshi, Tomita, Taisuke, Wong, Philip C., Green, William N., Kounnas, Maria Z., Thinakaran, Gopal
Published in The Journal of biological chemistry (16.01.2009)
Published in The Journal of biological chemistry (16.01.2009)
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Journal Article
Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates
Gong, Ping, Vetrivel, Kulandaivelu S., Nguyen, Phuong D., Meckler, Xavier, Cheng, Haipeng, Kounnas, Maria Z., Wagner, Steven L., Parent, Angèle T., Thinakaran, Gopal
Published in The Journal of biological chemistry (03.12.2010)
Published in The Journal of biological chemistry (03.12.2010)
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Journal Article
Ubiquilin 1 Modulates Amyloid Precursor Protein Trafficking and Aβ Secretion
Hiltunen, Mikko, Lu, Alice, Thomas, Anne V., Romano, Donna M., Kim, Minji, Jones, Phill B., Xie, Zhongcong, Kounnas, Maria Z., Wagner, Steven L., Berezovska, Oksana, Hyman, Bradley T., Tesco, Giuseppina, Bertram, Lars, Tanzi, Rudolph E.
Published in The Journal of biological chemistry (27.10.2006)
Published in The Journal of biological chemistry (27.10.2006)
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Journal Article
Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897
Anderson, Jeffery J., Holtz, Greg, Baskin, Patricia P., Turner, Mary, Rowe, Blake, Wang, Bowei, Kounnas, Maria Z., Lamb, Bruce T., Barten, Donna, Felsenstein, Kevin, McDonald, Ian, Srinivasan, Kumar, Munoz, Ben, Wagner, Steven L.
Published in Biochemical pharmacology (15.02.2005)
Published in Biochemical pharmacology (15.02.2005)
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Journal Article
NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ 42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents
Kounnas, Maria Z, Lane-Donovan, Courtney, Nowakowski, Dan W, Herz, Joachim, Comer, William T
Published in Alzheimer's & dementia : translational research & clinical interventions (01.01.2017)
Published in Alzheimer's & dementia : translational research & clinical interventions (01.01.2017)
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Journal Article
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
Kounnas, Maria Z, Moir, Robert D, Rebeck, G.William, Bush, Ashley I, Argraves, W.Scott, Tanzi, Rudolph E, Hyman, Bradley T, Strickland, Dudley K
Published in Cell (28.07.1995)
Published in Cell (28.07.1995)
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Journal Article
Cellular Internalization and Degradation of Antithrombin III-Thrombin, Heparin Cofactor II-Thrombin, and α1-Antitrypsin-Trypsin Complexes Is Mediated by the Low Density Lipoprotein Receptor-related Protein
Kounnas, Maria Z., Church, Frank C., Argraves, W. Scott, Strickland, Dudley K.
Published in The Journal of biological chemistry (01.03.1996)
Published in The Journal of biological chemistry (01.03.1996)
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Journal Article