Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model
Levová, Katerina, Moserová, Michaela, Kotrbová, Vera, Sulc, Miroslav, Henderson, Colin J, Wolf, C Roland, Phillips, David H, Frei, Eva, Schmeiser, Heinz H, Mares, Jaroslav, Arlt, Volker M, Stiborová, Marie
Published in Toxicological sciences (01.05.2011)
Published in Toxicological sciences (01.05.2011)
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Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH:Cytochrome P450 reductase null mouse
Stiborová, Marie, Arlt, Volker M., Henderson, Colin J., Wolf, C. Roland, Kotrbová, Věra, Moserová, Michaela, Hudeček, Jiří, Phillips, David H., Frei, Eva
Published in Toxicology and applied pharmacology (01.02.2008)
Published in Toxicology and applied pharmacology (01.02.2008)
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The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
AIMOVA, Dagmar, SVOBODOVA, Lucie, KOTRBOVA, Vera, MRAZOVA, Barbora, HODEK, Petr, HUDECEK, Jiri, VACLAVIKOVA, Radka, FREI, Eva, STIBOROVA, Marie
Published in Drug metabolism and disposition (01.10.2007)
Published in Drug metabolism and disposition (01.10.2007)
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Abstract 5419: The plant alkaloid ellipticine is detoxified by cytochrome P450 1A1/2 (CYP 1A1/2) but activated and forms DNA adducts if CYP1A1 or 1A2 is combined with cytochrome b5: an explanation for an in vivo/in vitro discrepancy
Frei, Eva, Kotrbova, Vera, Martinek, Vaclav, Breuer, Andrea, Stiborova, Marie
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Cytochrome b sub(5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy)
Kotrbova, Vera, Mrazova, Barbora, Moserova, Michaela, Martinek, Vaclav, Hodek, Petr, Hudecek, Jiri, Frei, Eva, Stiborova, Marie
Published in Biochemical pharmacology (15.09.2011)
Published in Biochemical pharmacology (15.09.2011)
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Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy
Kotrbová, Věra, Mrázová, Barbora, Moserová, Michaela, Martínek, Václav, Hodek, Petr, Hudeček, Jiří, Frei, Eva, Stiborová, Marie
Published in Biochemical pharmacology (15.09.2011)
Published in Biochemical pharmacology (15.09.2011)
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Cytochrome b5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy
Kotrbová, Věra, Mrázová, Barbora, Moserová, Michaela, Martínek, Václav, Hodek, Petr, Hudeček, Jiří, Frei, Eva, Stiborová, Marie
Published in Biochemical pharmacology (15.09.2011)
Published in Biochemical pharmacology (15.09.2011)
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Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes
Kotrbová, Vera, Aimová, Dagmar, Brezinová, Anna, Janouchová, Katerina, Poljaková, Jitka, Frei, Eva, Stiborová, Marie
Published in Neuro-endocrinology letters (01.12.2006)
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Published in Neuro-endocrinology letters (01.12.2006)
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Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney
Stiborova, Marie, Moserova, Michaela, Mrazova, Barbora, Kotrbova, Vera, Frei, Eva
Published in Neuro-endocrinology letters (2010)
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Published in Neuro-endocrinology letters (2010)
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Preparation of a biologically active apo-cytochrome b sub(5) via heterologous expression in Escherichia coli
Kotrbova, Vera, Aimova, Dagmar, Ingr, Marek, Borek-Dohalska, Lucie, Martinek, Vaclav, Stiborova, Marie
Published in Protein expression and purification (01.08.2009)
Published in Protein expression and purification (01.08.2009)
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Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA
Moserova, Michaela, Kotrbova, Vera, Rupertova, Martina, Naiman, Karel, Hudecek, Jiri, Hodek, Petr, Frei, Eva, Stiborova, Marie
Published in Neuro-endocrinology letters (01.10.2008)
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Published in Neuro-endocrinology letters (01.10.2008)
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Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method
Moserová, Michaela, Kotrbová, Věra, Aimová, Dagmar, Šulc, Miroslav, Frei, Eva, Stiborová, Marie
Published in Interdisciplinary toxicology (01.12.2009)
Published in Interdisciplinary toxicology (01.12.2009)
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Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2
Aimová, Dagmar, Poljaková, Jitka, Kotrbová, Věra, Moserová, Michaela, Frei, Eva, Arlt, Volker, Stiborová, Marie
Published in Interdisciplinary toxicology (01.09.2008)
Published in Interdisciplinary toxicology (01.09.2008)
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