Pathways to cures for multiple sclerosis: A research roadmap
Bebo, Bruce F, Allegretta, Mark, Landsman, Douglas, Zackowski, Kathy M, Brabazon, Fiona, Kostich, Walter A, Coetzee, Timothy, Ng, Alexander Victor, Marrie, Ruth Ann, Monk, Kelly R, Bar-Or, Amit, Whitacre, Caroline C
Published in Multiple sclerosis (01.03.2022)
Published in Multiple sclerosis (01.03.2022)
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Discovery of (S)‑1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein‑2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Maishal, Tarun Kumar, Thiyagarajan, Kamalraj, Jalagam, Prasadrao, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Das, Manish Lal, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Ditta, Jonathan, Mathur, Arvind, Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Vetrichelvan, Muthalagu, Gupta, Anuradha, Wilson, Alan, Gopinathan, Suma, Wason, Suman, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain
Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Lal Das, Manish, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2‑Associated Kinase 1 Inhibitors
Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C. M. Vijaya, Manepalli, Raju K. V. L. P, Sarvasiddhi, Sarat Kumar, Honkhambe, Swarnamba, Patankar, Vidya, Dasgupta, Bireshwar, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel M, Ghosh, Kaushik, Pokross, Matthew, Kiefer, Susan E, Brown, Jeffrey M, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Lippy, Jonathan S, Surti, Neha, Hamman, Brian D, Allen, Jason, Kostich, Walter A, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists
Mercer, Stephen E., Chaturvedula, Prasad V., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Pin, Sokhom S., Macci, Robert, Schartman, Richard, Signor, Laura J., Widmann, Kimberly A., Whiterock, Valerie J., Chen, Ping, Xu, Cen, Herbst, John J., Kostich, Walter A., Thalody, George, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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Discovery of (5S,6S,9R)‑5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro‑5H‑cyclohepta[b]pyridin-9-yl 4‑(2-oxo-2,3-dihydro‑1H‑imidazo[4,5‑b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine
Luo, Guanglin, Chen, Ling, Conway, Charles M., Denton, Rex, Keavy, Deborah, Signor, Laura, Kostich, Walter, Lentz, Kimberley A., Santone, Kenneth S., Schartman, Richard, Browning, Marc, Tong, Gary, Houston, John G., Dubowchik, Gene M., Macor, John E.
Published in Journal of medicinal chemistry (13.12.2012)
Published in Journal of medicinal chemistry (13.12.2012)
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Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists
Tora, George, Degnan, Andrew P., Conway, Charles M., Kostich, Walter A., Davis, Carl D., Pin, Sokhom S., Schartman, Richard, Xu, Cen, Widmann, Kimberly A., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
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Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia
Higgins, Mendi A., Marcin, Lawrence R., Christopher Zusi, F., Gentles, Robert, Ding, Min, Pearce, Bradley C., Easton, Amy, Kostich, Walter A., Seager, Matthew A., Bourin, Clotilde, Bristow, Linda J., Johnson, Kim A., Miller, Regina, Hogan, John, Whiterock, Valerie, Gulianello, Michael, Ferrante, Meredith, Huang, Yanling, Hendricson, Adam, Alt, Andrew, Macor, John E., Bronson, Joanne J.
Published in Bioorganic & medicinal chemistry (15.01.2017)
Published in Bioorganic & medicinal chemistry (15.01.2017)
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Small Molecule Receptor Protein Tyrosine Phosphatase γ (RPTPγ) Ligands That Inhibit Phosphatase Activity via Perturbation of the Tryptophan–Proline–Aspartate (WPD) Loop
Sheriff, Steven, Beno, Brett R, Zhai, Weixu, Kostich, Walter A, McDonnell, Patricia A, Kish, Kevin, Goldfarb, Valentina, Gao, Mian, Kiefer, Susan E, Yanchunas, Joseph, Huang, Yanling, Shi, Shuhao, Zhu, Shirong, Dzierba, Carolyn, Bronson, Joanne, Macor, John E, Appiah, Kingsley K, Westphal, Ryan S, O’Connell, Jonathan, Gerritz, Samuel W
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors
Appiah, Kingsley K, Kostich, Walter A, Gerritz, Samuel W, Huang, Yanling, Hamman, Brian D, Allen, Jason, Zhang, Wandong, Lanthorn, Thomas H, Albright, Charles F, Westphal, Ryan, Banks, Martyn N, O'Connell, Jonathan C
Published in Journal of biomolecular screening (01.06.2011)
Published in Journal of biomolecular screening (01.06.2011)
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Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms
Kish, Kevin, McDonnell, Patricia A., Goldfarb, Valentina, Gao, Mian, Metzler, William J., Langley, David R., Bryson, James W., Kiefer, Susan E., Carpenter, Brian, Kostich, Walter A., Westphal, Ryan S., Sheriff, Steven
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.07.2011)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.07.2011)
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Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase [gamma] in three different crystal forms
Kish, Kevin, McDonnell, Patricia A., Goldfarb, Valentina, Gao, Mian, Metzler, William J., Langley, David R., Bryson, James W., Kiefer, Susan E., Carpenter, Brian, Kostich, Walter A., Westphal, Ryan S., Sheriff, Steven
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.07.2011)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.07.2011)
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From the prodromal stage of multiple sclerosis to disease prevention
Marrie, Ruth Ann, Allegretta, Mark, Barcellos, Lisa F., Bebo, Bruce, Calabresi, Peter A., Correale, Jorge, Davis, Benjamin, De Jager, Philip L., Gasperi, Christiane, Greenbaum, Carla, Helme, Anne, Hemmer, Bernhard, Kanellis, Pamela, Kostich, Walter, Landsman, Douglas, Lebrun-Frenay, Christine, Makhani, Naila, Munger, Kassandra L., Okuda, Darin T., Ontaneda, Daniel, Postuma, Ronald B., Quandt, Jacqueline A., Roman, Sharon, Saidha, Shiv, Sormani, Maria Pia, Strum, Jon, Valentine, Pamela, Walton, Clare, Zackowski, Kathleen M., Zhao, Yinshan, Tremlett, Helen
Published in Nature reviews. Neurology (01.09.2022)
Published in Nature reviews. Neurology (01.09.2022)
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Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2‑Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain
Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C.M. Vijaya, Brown, Jeffrey M, Bristow, Linda J, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel, Kiefer, Susan E, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Easton, Amy, Lippy, Jonathan S, Surti, Neha, Pattipati, Sreenivasulu N, Dokania, Manoj, Elavazhagan, Saravanan, Dandapani, Kumaran, Hamman, Brian D, Allen, Jason, Kostich, Walter, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
Kostich, Walter, Hamman, Brian D, Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V, Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K, Gulianello, Michael, Molski, Ted, Brown, Jeffrey M, Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O'Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H, Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E, Lentz, Kimberley A, Santone, Kenneth S, Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K, Nara, Susheel J, Dzierba, Carolyn, Bronson, Joanne, Macor, John E, Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M, Zambrowicz, Brian, Albright, Charles F
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
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Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead
Luo, Guanglin, Jiang, Xiang-Jun, Chen, Ling, Conway, Charles M., Gulianello, Michael, Kostich, Walter, Keavy, Deborah, Signor, Laura J., Chen, Ping, Davis, Carl, Whiterock, Valerie J., Schartman, Richard, Widmann, Kimberly A., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
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Journal Article
Asymmetric Synthesis of Heterocyclic Analogues of a CGRP Receptor Antagonist for Treating Migraine
Luo, Guanglin, Chen, Ling, Conway, Charles M., Kostich, Walter, Macor, John E., Dubowchik, Gene M.
Published in Organic letters (18.12.2015)
Published in Organic letters (18.12.2015)
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Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis
Luo, Guanglin, Chen, Ling, Conway, Charles M, Kostich, Walter, Johnson, Benjamin M, Ng, Alicia, Macor, John E, Dubowchik, Gene M
Published in Journal of organic chemistry (07.04.2017)
Published in Journal of organic chemistry (07.04.2017)
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