ReacLLaMA: Merging chemical and textual information in chemical reactivity AI models
Hartgers, Aline, Nugmanov, Ramil, Chernichenko, Kostiantyn, Wegner, Joerg Kurt
Published in arXiv.org (30.01.2024)
Published in arXiv.org (30.01.2024)
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NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE
SINGH, Amartjit, KOLOTUCHIN, Sergei, WAGSCHAL, Simon Albert, BEN HAIM, Cyril, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, WEI, Carolyn S, FAN, Yu, LEMAIRE, Sébastien François Emmanuel, SIMMONS, Eric M, CAO, Duy Chi Trung
Year of Publication 03.01.2024
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Year of Publication 03.01.2024
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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 06.06.2024
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Year of Publication 06.06.2024
Patent
NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE
KOLOTUCHIN, Sergei, WAGSCHAL, Simon Albert, SINGH, Amarjit, BEN HAIM, Cyril, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, WEI, Carolyn S, FAN, Yu, LEMAIRE, Sébastien François Emmanuel, SIMMONS, Eric M, CAO, Duy Chi Trung
Year of Publication 22.11.2023
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Year of Publication 22.11.2023
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NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE
SINGH, Amartjit, KOLOTUCHIN, Sergei, WAGSCHAL, Simon Albert, BEN HAIM, Cyril, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, WEI, Carolyn S, FAN, Yu, LEMAIRE, Sébastien François Emmanuel, SIMMONS, Eric M, CAO, Duy Chi Trung
Year of Publication 30.08.2023
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Year of Publication 30.08.2023
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PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 28.12.2023
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Year of Publication 28.12.2023
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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 16.08.2023
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Year of Publication 16.08.2023
Patent
A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 08.06.2023
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Year of Publication 08.06.2023
Patent
A process toward the manufacture of (6r,10s)-10-{4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b] [1,7]diazacyclotetradecin-5(6h)-one
WAGSCHAL Simon Albert, CAO Duy Chi Trung, MOWER Matthew Penfield, PEREGO Luca Alessandro, BROGGINI Diego Fernando Domenico, GALLAGHER William P, WEI Carolyn S, SCHMALZBAUER Bj?rn, KOSCHKER Philipp, ZHDANKO Alexander, WISNIEWSKI Steven R, MUKHERJEE Subha, SINGH Amarjit, CHERNICHENKO Kostiantyn, TRAN Ngoc Duc, XIOURAS Christos, ORTIZ Adrian, CUNIERE Nicolas, ZHENG Bin, JAMISON Christopher Robert, SKLIAR Dimitri, EASTGATE Martin D, KOLOTUCHIN Sergei, MATCHA Kiran, LUO Helen Y, SFOUGGATAKIS Chris, LEMAIRE S?bastien Fran?ois Emmanuel, JUSSEAU Xavier Jean-Marie, BEN HA?M Cyril, REUTER Karl, RAHMANI Ramdane
Year of Publication 01.06.2023
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Year of Publication 01.06.2023
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NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
LEMAIRE, Sebastien Francois Emmanuel, WAGSCHAL, Simon Albert, SINGH, Amarjit, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, KOLUTUCHIN, Sergei, WEI, Carolyn S, FAN, Yu, SIMMONS, Eric M, BEN HAÏM, Cyril, CAO, Duy Chi Trung
Year of Publication 12.05.2022
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Year of Publication 12.05.2022
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NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE
KOLOTUCHIN, Sergei, WAGSCHAL, Simon Albert, SINGH, Amarjit, BEN HAIM, Cyril, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, WEI, Carolyn S, FAN, Yu, LEMAIRE, Sébastien François Emmanuel, SIMMONS, Eric M, CAO, Duy Chi Trung
Year of Publication 16.02.2022
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Year of Publication 16.02.2022
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Novel synthetic options towards the manufacture of (6R,10S)-10- {4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)- pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15 -(metheno)pyrazolo [4,3-b] [1,7] diazacyclotetradecin-5(6H)-one
KOLOTUCHIN, Sergei, WAGSCHAL, Simon Albert, SINGH, Amarjit, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, BEN ΗΑΪΜ, Cyril, WEI, Carolyn S, FAN, Yu, LEMAIRE, Sébastien François Emmanuel, SIMMONS, Eric M, CAO, Duy Chi Trung
Year of Publication 02.12.2021
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Year of Publication 02.12.2021
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Novel synthetic options towards the manufacture of (6r,10s)-10- {4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)- pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15 -(metheno)pyrazolo [4,3-b] [1,7] diazacyclotetradecin-5(6h)-one
WAGSCHAL Simon Albert, CAO Duy Chi Trung, BEN ???? Cyril, FAN Yu, CUNIERE Nicolas, ZHENG Bin, BROGGINI Diego Fernando Domenico, XIAO Yi, WEI Carolyn S, KOLOTUCHIN Sergei, MUKHERJEE Subha, LEMAIRE S?bastien Fran?ois Emmanuel, SIMMONS Eric M, SINGH Amarjit, CHERNICHENKO Kostiantyn, YUAN Changxia
Year of Publication 01.12.2021
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Year of Publication 01.12.2021
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NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE
KOLOTUCHIN, Sergei, WAGSCHAL, Simon Albert, SINGH, Amarjit, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, BEN ΗΑΪΜ, Cyril, WEI, Carolyn S, FAN, Yu, LEMAIRE, Sébastien François Emmanuel, SIMMONS, Eric M, CAO, Duy Chi Trung
Year of Publication 29.11.2021
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Year of Publication 29.11.2021
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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 21.04.2022
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Year of Publication 21.04.2022
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A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
REUTER, KARL, SINGH, AMARJIT, PEREGO, LUCA ALESSANDRO, WEI, CAROLYN S, WAGSCHAL, SIMON ALBERT, ZHDANKO, ALEXANDER, TRAN, NGOC DUC, WISNIEWSKI, STEVEN R, XIOURAS, CHRISTOS, LEMAIRE, SEBASTIEN FRANCOIS EMMANUEL, JAMISON, CHRISTOPHER ROBERT, SCHMALZBAUER, BJORN, SFOUGGATAKIS, CHRIS, MUKHERJEE, SUBHA, CUNIERE, NICOLAS, ZHENG, BIN, GALLAGHER, WILLIAM P, SKLIAR, DIMITRI, LUO, HELEN Y, JUSSEAU, XAVIER JEAN-MARIE, BEN HAIM, CYRIL, MATCHA, KIRAN, KOLOTUCHIN, SERGEI, ORTIZ, ADRIAN, KOSCHKER, PHILIPP, EASTGATE, MARTIN D, BROGGINI, DIEGO FERNANDO DOMENICO, MOWER, MATTHEW PENFIELD, CHERNICHENKO, KOSTIANTYN, RAHMANI, RAMDANE, CAO, DUY CHI TRUNG
Year of Publication 21.04.2022
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Year of Publication 21.04.2022
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NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE
KOLOTUCHIN, Sergei, WAGSCHAL, Simon Albert, SINGH, Amarjit, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, WEI, Carolyn S, FAN, Yu, LEMAIRE, Sébastien François Emmanuel, SIMMONS, Eric M, CAO, Duy Chi Trung
Year of Publication 15.10.2020
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Year of Publication 15.10.2020
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