Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery
Lee, E-Chiang, Liang, Qi, Ali, Hanif, Bayliss, Luke, Beasley, Alastair, Bloomfield-Gerdes, Tara, Bonoli, Laura, Brown, Richard, Campbell, Jamie, Carpenter, Adam, Chalk, Sara, Davis, Alison, England, Nick, Fane-Dremucheva, Alla, Franz, Bettina, Germaschewski, Volker, Holmes, Helen, Holmes, Steve, Kirby, Ian, Kosmac, Miha, Legent, Anais, Lui, Hui, Manin, Anais, O'Leary, Siobhan, Paterson, Jemima, Sciarrillo, Rocco, Speak, Anneliese, Spensberger, Dominik, Tuffery, Laura, Waddell, Nikole, Wang, Wei, Wells, Sophie, Wong, Vivian, Wood, Andrew, Owen, Michael J, Friedrich, Glenn A, Bradley, Allan
Published in Nature biotechnology (01.04.2014)
Published in Nature biotechnology (01.04.2014)
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Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing
Richardson, Eve, Binter, Špela, Kosmac, Miha, Ghraichy, Marie, von Niederhäusern, Valentin, Kovaltsuk, Aleksandr, Galson, Jacob D, Trück, Johannes, Kelly, Dominic F, Deane, Charlotte M, Kellam, Paul, Watson, Simon J
Published in eLife (27.03.2023)
Published in eLife (27.03.2023)
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437 Optimised achilles VELOSTM process 2b manufacturing platform generates a significant dose boost of reactive CD8 and CD4 clonal neoantigen-reactive T cells for the treatment of solid cancer
Sassi, Monica, Gomez, Sandro, Rologi, Evi, Madigan, Meghan, Tang, Joanne, Thirkell, Sarah, Banwo, Samuel Jide, Ogunleye, Temi, McKeeman, Sophie, Law, Claire, Meyyappan, Unnaamalai, Kotsiou, Eleni, Newton, Katy, Oakes, Theres, Kosmac, Miha, Goodsell, Luke, Carolan, Connor, Ahern, Justin, Hillyer, Tim, Ndlovu, Bongi, Fraser, Henrieta, Quezada, Sergio A, Samuel, Edward
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Exploring the Binding Sites of Anti-Infliximab Antibodies in Pediatric Patients With Rheumatic Diseases Treated With Infliximab
Kosmač, Miha, Avčin, Tadej, Toplak, Nataša, Simonini, Gabriele, Cimaz, Rolando, Šerbec, Vladka Čurin
Published in Pediatric research (01.03.2011)
Published in Pediatric research (01.03.2011)
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Epitope mapping of a PrP(Sc)-specific monoclonal antibody: Identification of a novel C-terminally truncated prion fragment
Kosmač, Miha, Koren, Simon, Giachin, Gabriele, Stoilova, Tatiana, Gennaro, Renato, Legname, Giuseppe, Šerbec, Vladka Čurin
Published in Molecular immunology (01.02.2011)
Published in Molecular immunology (01.02.2011)
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Abstract 4953: Differential expression of ICOS on circulating immune cells and tumor infiltrating lymphocytes in patient with solid tumors
Sainson, Richard C., Kosmac, Miha, Kimber, Rachael, Carvalho, Joana, Bohris, Gwenoline, Thotakura, Anil, Melvin, David, McCourt, Matthew
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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The tidyomics ecosystem: enhancing omic data analyses
Hutchison, William J., Keyes, Timothy J., Crowell, Helena L., Serizay, Jacques, Soneson, Charlotte, Davis, Eric S., Sato, Noriaki, Moses, Lambda, Tarlinton, Boyd, Nahid, Abdullah A., Kosmac, Miha, Clayssen, Quentin, Yuan, Victor, Mu, Wancen, Park, Ji-Eun, Mamede, Izabela, Ryu, Min Hyung, Axisa, Pierre-Paul, Paiz, Paulina, Poon, Chi-Lam, Tang, Ming, Gottardo, Raphael, Morgan, Martin, Lee, Stuart, Lawrence, Michael, Hicks, Stephanie C., Nolan, Garry P., Davis, Kara L., Papenfuss, Anthony T., Love, Michael I., Mangiola, Stefano
Published in Nature methods (01.07.2024)
Published in Nature methods (01.07.2024)
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Abstract LB-153: KY1055, a novel ICOS-PD-L1 bispecific antibody, efficiently enhances T cell activation and delivers a potent anti-tumour response in vivo
Sainson, Richard C., Parveen, Nahida, Borhis, Gwenoline, Kosmac, Miha, OKell, Tracey, Taggart, Emma, Carvalho, Joana, McCourt, Matthew, Ali, Hanif, Craig, Hannah, Labokha, Aksana
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression
Sainson, Richard C A, Thotakura, Anil K, Kosmac, Miha, Borhis, Gwenoline, Parveen, Nahida, Kimber, Rachael, Carvalho, Joana, Henderson, Simon J, Pryke, Kerstin L, Okell, Tracey, O'Leary, Siobhan, Ball, Stuart, Van Krinks, Cassie, Gamand, Lauriane, Taggart, Emma, Pring, Eleanor J, Ali, Hanif, Craig, Hannah, Wong, Vivian W Y, Liang, Qi, Rowlands, Robert J, Lecointre, Morgane, Campbell, Jamie, Kirby, Ian, Melvin, David, Germaschewski, Volker, Oelmann, Elisabeth, Quaratino, Sonia, McCourt, Matthew
Published in Cancer immunology research (01.12.2020)
Published in Cancer immunology research (01.12.2020)
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ICOS ANTI-ICOS ANTIBODIES
ARKINSTALL STEPHEN JOHN, GERMASCHEWSKI VOLKER, MCCOURT MATTHEW JOHN, CAMPBELL JAMIE IAIN, KIRBY IAN, KOSMAC MIHA, ALI MOHAMMED HANIF, SANDY NIKOLE, DEANTONIO CECILIA, LEE E CHIANG, GALLAGHER THOMAS, VAN KRINKS CASSANDRA, GILLIES STEPHEN DOUGLAS, SAINSON RICHARD CHARLES ALFRED
Year of Publication 31.03.2023
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Year of Publication 31.03.2023
Patent
항-PD-L1 및 IL-2 사이토카인
CAMPBELL JAMIE, SANDY NIKOLE, ARKINSTALL STEPHEN JOHN, GERMASCHEWSKI VOLKER, DEANTONIO CECILIA, KIRBY IAN, GALLAGHER THOMAS, VAN KRINKS CASSANDRA, KOSMAC MIHA
Year of Publication 27.03.2019
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Year of Publication 27.03.2019
Patent
항체, 용도 및 방법
CAMPBELL JAMIE, HOLMES STEVE, KIRBY IAN, KEEN LESLIE SUSAN, TKACHEV VICTOR, BLAND WARD PHILIP, KOSMAC MIHA
Year of Publication 08.11.2017
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Year of Publication 08.11.2017
Patent
항-PD-L1 항체
CAMPBELL JAMIE, SANDY NIKOLE, ARKINSTALL STEPHEN JOHN, GERMASCHEWSKI VOLKER, DEANTONIO CECILIA, KIRBY IAN, GALLAGHER THOMAS, VAN KRINKS CASSANDRA, KOSMAC MIHA, GILLIES STEPHEN DOUGLAS
Year of Publication 21.03.2019
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Year of Publication 21.03.2019
Patent
항-ICOS 항체
ARKINSTALL STEPHEN JOHN, GERMASCHEWSKI VOLKER, MCCOURT MATTHEW JOHN, CAMPBELL JAMIE IAIN, KIRBY IAN, KOSMAC MIHA, ALI MOHAMMED HANIF, SANDY NIKOLE, DEANTONIO CECILIA, LEE E CHIANG, GALLAGHER THOMAS, VAN KRINKS CASSANDRA, GILLIES STEPHEN DOUGLAS, SAINSON RICHARD CHARLES ALFRED
Year of Publication 08.04.2019
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Year of Publication 08.04.2019
Patent