Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor
Brus, Boris, Košak, Urban, Turk, Samo, Pišlar, Anja, Coquelle, Nicolas, Kos, Janko, Stojan, Jure, Colletier, Jacques-Philippe, Gobec, Stanislav
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
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Journal Article
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity
Košak, Urban, Brus, Boris, Knez, Damijan, Žakelj, Simon, Trontelj, Jurij, Pišlar, Anja, Šink, Roman, Jukič, Marko, Živin, Marko, Podkowa, Adrian, Nachon, Florian, Brazzolotto, Xavier, Stojan, Jure, Kos, Janko, Coquelle, Nicolas, Sałat, Kinga, Colletier, Jacques-Philippe, Gobec, Stanislav
Published in Journal of medicinal chemistry (11.01.2018)
Published in Journal of medicinal chemistry (11.01.2018)
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Journal Article
Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease
Knez, Damijan, Sova, Matej, Košak, Urban, Gobec, Stanislav
Published in Future medicinal chemistry (01.05.2017)
Published in Future medicinal chemistry (01.05.2017)
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Journal Article
Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor
Zakošek Pipan, Maja, Prpar Mihevc, Sonja, Štrbenc, Malan, Košak, Urban, German Ilić, Ilija, Trontelj, Jurij, Žakelj, Simon, Gobec, Stanislav, Pavlin, Darja, Majdič, Gregor
Published in Scientific reports (13.09.2021)
Published in Scientific reports (13.09.2021)
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Journal Article
Development of an in-vivo active reversible butyrylcholinesterase inhibitor
Košak, Urban, Brus, Boris, Knez, Damijan, Šink, Roman, Žakelj, Simon, Trontelj, Jurij, Pišlar, Anja, Šlenc, Jasna, Gobec, Martina, Živin, Marko, Tratnjek, Larisa, Perše, Martina, Sałat, Kinga, Podkowa, Adrian, Filipek, Barbara, Nachon, Florian, Brazzolotto, Xavier, Więckowska, Anna, Malawska, Barbara, Stojan, Jure, Raščan, Irena Mlinarič, Kos, Janko, Coquelle, Nicolas, Colletier, Jacques-Philippe, Gobec, Stanislav
Published in Scientific reports (21.12.2016)
Published in Scientific reports (21.12.2016)
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Journal Article
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents
Košak, Urban, Knez, Damijan, Coquelle, Nicolas, Brus, Boris, Pišlar, Anja, Nachon, Florian, Brazzolotto, Xavier, Kos, Janko, Colletier, Jacques-Philippe, Gobec, Stanislav
Published in Bioorganic & medicinal chemistry (15.01.2017)
Published in Bioorganic & medicinal chemistry (15.01.2017)
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Journal Article
Repurposing of 8‐Hydroxyquinoline‐Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors
Gajic, Mihajlo, Knez, Damijan, Sosič, Izidor, Mravljak, Janez, Meden, Anže, Košak, Urban, Leitzbach, Luisa, George, Sven, Hofmann, Bettina, Zivkovic, Aleksandra, Steinhilber, Dieter, Stark, Holger, Gobec, Stanislav, Smelcerovic, Andrija, Anderluh, Marko
Published in ChemMedChem (04.03.2022)
Published in ChemMedChem (04.03.2022)
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Journal Article
N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents
Košak, Urban, Strašek, Nika, Knez, Damijan, Jukič, Marko, Žakelj, Simon, Zahirović, Abida, Pišlar, Anja, Brazzolotto, Xavier, Nachon, Florian, Kos, Janko, Gobec, Stanislav
Published in European journal of medicinal chemistry (01.07.2020)
Published in European journal of medicinal chemistry (01.07.2020)
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Journal Article
Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
Rejc, Luka, Gómez-Vallejo, Vanessa, Joya, Ana, Moreno, Oscar, Egimendia, Ander, Castellnou, Pilar, Ríos-Anglada, Xabier, Cossío, Unai, Baz, Zuriñe, Passannante, Rossana, Tobalina-Larrea, Ignacio, Ramos-Cabrer, Pedro, Giralt, Albert, Sastre, Magdalena, Capetillo-Zarate, Estibaliz, Košak, Urban, Knez, Damijan, Gobec, Stanislav, Marder, Mariel, Martin, Abraham, Llop, Jordi
Published in Theranostics (01.01.2021)
Published in Theranostics (01.01.2021)
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Journal Article
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
Pajk, Stane, Knez, Damijan, Košak, Urban, Zorović, Maja, Brazzolotto, Xavier, Coquelle, Nicolas, Nachon, Florian, Colletier, Jacques-Philippe, Živin, Marko, Stojan, Jure, Gobec, Stanislav
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
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Journal Article
Synthesis and Initial Characterization of a Reversible, Selective 18F-Labeled Radiotracer for Human Butyrylcholinesterase
Gentzsch, Christian, Chen, Xinyu, Spatz, Philipp, Košak, Urban, Knez, Damijan, Nose, Naoko, Gobec, Stanislav, Higuchi, Takahiro, Decker, Michael
Published in Molecular imaging and biology (2021)
Published in Molecular imaging and biology (2021)
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Journal Article
Convenient syntheses of orthogonally protected aminocyclopentitols from aldopentoses
Košak, Urban, Hrast, Martina, Knez, Damijan, Maraš, Nenad, Črnugelj, Martin, Gobec, Stanislav
Published in Tetrahedron letters (14.01.2015)
Published in Tetrahedron letters (14.01.2015)
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Journal Article
Synthesis and Initial Characterization of a Reversible, Selective 18 F-Labeled Radiotracer for Human Butyrylcholinesterase
Gentzsch, Christian, Chen, Xinyu, Spatz, Philipp, Košak, Urban, Knez, Damijan, Nose, Naoko, Gobec, Stanislav, Higuchi, Takahiro, Decker, Michael
Published in Molecular imaging and biology (01.08.2021)
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Published in Molecular imaging and biology (01.08.2021)
Journal Article
N-((1-BENZYLPIPERIDIN-3-YL)METHYL)-N-(2-METHOXYETHYL)NAPHTHALENE-2-SULFONAMIDE FOR THE TREATMENT OF CANINE COGNITIVE DYSFUNCTION AND OTHER FORMS OF DEMENTIA IN DOGS
MAJDIC, Gregor, MIHEVC, Sonja, Prpar, KOSAK, Urban, GOBEC, Stanislav, PIPAN, Maja, Zakosek
Year of Publication 02.08.2023
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Year of Publication 02.08.2023
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