LRRK2 Targeting Strategies as Potential Treatment of Parkinson’s Disease
Wojewska, Dominika Natalia, Kortholt, Arjan
Published in Biomolecules (Basel, Switzerland) (26.07.2021)
Published in Biomolecules (Basel, Switzerland) (26.07.2021)
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Journal Article
Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity
Sabogal-Guáqueta, Angélica María, Hobbie, Fabian, Keerthi, Akshaya, Oun, Asmaa, Kortholt, Arjan, Boddeke, Erik, Dolga, Amalia
Published in Biomedicine & pharmacotherapy (01.10.2019)
Published in Biomedicine & pharmacotherapy (01.10.2019)
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Journal Article
Roco Proteins: GTPases with a Baroque Structure and Mechanism
Wauters, Lina, Versées, Wim, Kortholt, Arjan
Published in International journal of molecular sciences (03.01.2019)
Published in International journal of molecular sciences (03.01.2019)
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Journal Article
LRRK2 protects immune cells against erastin-induced ferroptosis
Oun, Asmaa, Soliman, Ahmed, Trombetta-Lima, Marina, Tzepapadaki, Afroditi, Tsagkari, Dikaia, Kortholt, Arjan, Dolga, Amalia M.
Published in Neurobiology of disease (01.12.2022)
Published in Neurobiology of disease (01.12.2022)
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Journal Article
Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Guaitoli, Giambattista, Raimondi, Francesco, Gilsbach, Bernd K., Gómez-Llorente, Yacob, Deyaert, Egon, Renzi, Fabiana, Li, Xianting, Schaffner, Adam, Jagtap, Pravin Kumar Ankush, Boldt, Karsten, von Zweydorf, Felix, Gotthardt, Katja, Lorimer, Donald D., Yue, Zhenyu, Burgin, Alex, Janjic, Nebojsa, Sattler, Michael, Versées, Wim, Ueffing, Marius, Ubarretxena-Belandia, Iban, Kortholt, Arjan, Gloeckner, Christian Johannes
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
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Journal Article
The cytoskeleton regulates symmetry transitions in moving amoeboid cells
van Haastert, Peter J M, Keizer-Gunnink, Ineke, Kortholt, Arjan
Published in Journal of cell science (01.04.2018)
Published in Journal of cell science (01.04.2018)
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Journal Article
Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria
Buckley, Catherine M., Pots, Henderikus, Gueho, Aurelie, Vines, James H., Munn, Christopher J., Phillips, Ben A., Gilsbach, Bernd, Traynor, David, Nikolaev, Anton, Soldati, Thierry, Parnell, Andrew J., Kortholt, Arjan, King, Jason S.
Published in Current biology (03.08.2020)
Published in Current biology (03.08.2020)
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Journal Article
Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction
Sabogal-Guáqueta, Angélica María, Marmolejo-Garza, Alejandro, Trombetta-Lima, Marina, Oun, Asmaa, Hunneman, Jasmijn, Chen, Tingting, Koistinaho, Jari, Lehtonen, Sarka, Kortholt, Arjan, Wolters, Justina C., Bakker, Barbara M., Eggen, Bart J. L., Boddeke, Erik, Dolga, Amalia
Published in Nature communications (13.10.2023)
Published in Nature communications (13.10.2023)
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Journal Article
GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis
Xu, Xuehua, Wen, Xi, Veltman, Douwe M., Keizer-Gunnink, Ineke, Pots, Henderikus, Kortholt, Arjan, Jin, Tian
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2017)
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Journal Article
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Singh, Ranjan K, Soliman, Ahmed, Guaitoli, Giambattista, Störmer, Eliza, von Zweydorf, Felix, Dal Maso, Thomas, Oun, Asmaa, Van Rillaer, Laura, Schmidt, Sven H, Chatterjee, Deep, David, Joshua A, Pardon, Els, Schwartz, Thomas U, Knapp, Stefan, Kennedy, Eileen J, Steyaert, Jan, Herberg, Friedrich W, Kortholt, Arjan, Gloeckner, Christian Johannes, Versées, Wim
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2022)
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Journal Article
Forty-five years of cGMP research in Dictyostelium : understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis
van Haastert, Peter J M, Keizer-Gunnink, Ineke, Pots, Henderikus, Ortiz-Mateos, Claudia, Veltman, Douwe, van Egmond, Wouter, Kortholt, Arjan
Published in Molecular biology of the cell (01.10.2021)
Published in Molecular biology of the cell (01.10.2021)
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Journal Article
Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages
Oun, Asmaa, Hoeksema, Emmy, Soliman, Ahmed, Brouwer, Famke, García-Reyes, Fabiola, Pots, Henderikus, Trombetta-Lima, Marina, Kortholt, Arjan, Dolga, Amalia M
Published in International journal of molecular sciences (13.01.2023)
Published in International journal of molecular sciences (13.01.2023)
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Journal Article
A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover
Deyaert, Egon, Wauters, Lina, Guaitoli, Giambattista, Konijnenberg, Albert, Leemans, Margaux, Terheyden, Susanne, Petrovic, Arsen, Gallardo, Rodrigo, Nederveen-Schippers, Laura M., Athanasopoulos, Panagiotis S., Pots, Henderikus, Van Haastert, Peter J. M., Sobott, Frank, Gloeckner, Christian Johannes, Efremov, Rouslan, Kortholt, Arjan, Versées, Wim
Published in Nature communications (18.10.2017)
Published in Nature communications (18.10.2017)
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Journal Article
Editorial: LRRK2-Fifteen Years From Cloning to the Clinic
Rideout, Hardy, Greggio, Elisa, Kortholt, Arjan, Nichols, R Jeremy
Published in Frontiers in neuroscience (11.04.2022)
Published in Frontiers in neuroscience (11.04.2022)
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