Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders
Peters, Sebastian, Wirkert, Eva, Kuespert, Sabrina, Heydn, Rosmarie, Johannesen, Siw, Friedrich, Anita, Mailänder, Susanne, Korte, Sven, Mecklenburg, Lars, Aigner, Ludwig, Bruun, Tim-Henrik, Bogdahn, Ulrich
Published in Pharmaceutics (15.01.2022)
Published in Pharmaceutics (15.01.2022)
Get full text
Journal Article
Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling
Peters, Sebastian, Kuespert, Sabrina, Wirkert, Eva, Heydn, Rosmarie, Jurek, Benjamin, Johannesen, Siw, Hsam, Ohnmar, Korte, Sven, Ludwig, Florian Timo, Mecklenburg, Lars, Mrowetz, Heike, Altendorfer, Barbara, Poupardin, Rodolphe, Petri, Susanne, Thal, Dietmar R., Hermann, Andreas, Weishaupt, Jochen H., Weis, Joachim, Aksoylu, Inci Sevval, Lewandowski, Sebastian A., Aigner, Ludwig, Bruun, Tim-Henrik, Bogdahn, Ulrich
Published in Neurotherapeutics (01.07.2021)
Published in Neurotherapeutics (01.07.2021)
Get full text
Journal Article
Targeting TGF-ß in the Central Nervous System: Assessment of Cynomolgus Monkey—Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide
Peters, Sebastian, Wirkert, Eva, Kuespert, Sabrina, Heydn, Rosmarie, Korte, Sven, Mecklenburg, Lars, Aigner, Ludwig, Johannesen, Siw, Bruun, Tim-Henrik, Bogdahn, Ulrich
Published in Applied sciences (01.02.2022)
Published in Applied sciences (01.02.2022)
Get full text
Journal Article
Feasibility of intravitreal injections and ophthalmic safety assessment in marmoset ( Callithrix jacchus ) monkeys
Korbmacher, Birgit, Atorf, Jenny, Fridrichs-Gromoll, Stephanie, Hill, Marilyn, Korte, Sven, Kremers, Jan, Mansfield, Keith, Mecklenburg, Lars, Pilling, Andrew, Wiederhold, Andreas
Published in Primate Biology (2017)
Published in Primate Biology (2017)
Get full text
Journal Article
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman Primates
Berman-Booty, Lisa D, Klein, Stephanie K, Mazur, Curt, Schroeder, Joseph, Korte, Sven, Ludwig, Florian T, Romeike, Annette, Bolon, Brad, Grieves, Jessica L
Published in Toxicologic pathology (01.08.2023)
Published in Toxicologic pathology (01.08.2023)
Get more information
Journal Article
Range of Neurological Signs in Cynomolgus Monkeys After Intrathecal Bolus Administration of Antisense Oligonucleotides
Korte, Sven, Runge, Frank, Wozniak, Magdalena M, Ludwig, Florian T, Smieja, Daniela, Korytko, Peter, Mecklenburg, Lars
Published in International journal of toxicology (01.11.2020)
Published in International journal of toxicology (01.11.2020)
Get more information
Journal Article
Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys
Korte, Sven, Luft, Jorge, von Keutz, Anne, Runge, Frank, Mecklenburg, Lars, Wozniak, Magdalena Maria, Zander, Serge, Ludwig, Florian Timo, Pajaziti, Betina, Romeike, Annette, Korytko, Peter
Published in International journal of toxicology (01.11.2020)
Published in International journal of toxicology (01.11.2020)
Get more information
Journal Article
Safety and Toxicology of Ocular Gene Therapy with Recombinant AAV Vector rAAV.hCNGA3 in Nonhuman Primates
Tobias, Peters, Philipp, Seitz Immanuel, Stylianos, Michalakis, Martin, Biel, Barbara, Wilhelm, Felix, Reichel, Alexander, Ochakovski Guy, Eberhart, Zrenner, Marius, Ueffing, Birgit, Korbmacher, Sven, Korte, Ulrich, Bartz-Schmidt Karl, Dominik, Fischer Manuel
Published in Human gene therapy. Clinical development (01.06.2019)
Published in Human gene therapy. Clinical development (01.06.2019)
Get more information
Journal Article
Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics
de Waal, Eric J., Desmidt, Maria, Korte, Sven, Niehoff, Marc, Chase, Kevan, Arrowsmith, Wayne, Lampo, Ann
Published in Journal of applied toxicology (01.09.2014)
Published in Journal of applied toxicology (01.09.2014)
Get full text
Journal Article
Feasibility of intravitreal injections and ophthalmic safety assessment in marmoset (Callithrix jacchus) monkeys
Korbmacher, Birgit, Atorf, Jenny, Fridrichs-Gromoll, Stephanie, Hill, Marilyn, Korte, Sven, Kremers, Jan, Mansfield, Keith, Mecklenburg, Lars, Pilling, Andrew, Wiederhold, Andreas
Published in Primate Biology (28.04.2017)
Published in Primate Biology (28.04.2017)
Get full text
Journal Article
Evaluation of the disturbing potential of IEMI using mathematical norms and analytical calculations
Korte, S., Garbe, H.
Published in 2008 International Symposium on Electromagnetic Compatibility - EMC Europe (01.09.2008)
Published in 2008 International Symposium on Electromagnetic Compatibility - EMC Europe (01.09.2008)
Get full text
Conference Proceeding
Susceptibility of Electronic Devices to Variable Transient Spectra
Korte, S., Garbe, H.
Published in 2007 IEEE International Symposium on Electromagnetic Compatibility (01.07.2007)
Published in 2007 IEEE International Symposium on Electromagnetic Compatibility (01.07.2007)
Get full text
Conference Proceeding
Increased serum neopterin levels in acutely ill and recovered schizophrenic patients
Korte, Sven, Arolt, Volker, Peters, Marion, Weitzsch, Christine, Rothermundt, Matthias, Kirchner, Holger
Published in Schizophrenia research (22.06.1998)
Published in Schizophrenia research (22.06.1998)
Get full text
Journal Article
Marmoset
Published in Non-Clinical Vascular Infusion Technology, Volume II
(2014)
Get full text
Book Chapter
Marmoset
Published in Non-Clinical Vascular Infusion Technology, Two Volume Set
(2014)
Get full text
Book Chapter