Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate
Rodriguez Camargo, Diana C, Korshavn, Kyle J, Jussupow, Alexander, Raltchev, Kolio, Goricanec, David, Fleisch, Markus, Sarkar, Riddhiman, Xue, Kai, Aichler, Michaela, Mettenleiter, Gabriele, Walch, Axel Karl, Camilloni, Carlo, Hagn, Franz, Reif, Bernd, Ramamoorthy, Ayyalusamy
Published in eLife (17.11.2017)
Published in eLife (17.11.2017)
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Journal Article
Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer
Guerra, Rachel M., Bird, Gregory H., Harvey, Edward P., Dharia, Neekesh V., Korshavn, Kyle J., Prew, Michelle S., Stegmaier, Kimberly, Walensky, Loren D.
Published in Cell reports (Cambridge) (25.09.2018)
Published in Cell reports (Cambridge) (25.09.2018)
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Journal Article
Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation
Korshavn, Kyle J, Bhunia, Anirban, Lim, Mi Hee, Ramamoorthy, Ayyalusamy
Published in Chemical communications (Cambridge, England) (01.01.2016)
Published in Chemical communications (Cambridge, England) (01.01.2016)
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Journal Article
Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β
Korshavn, Kyle J., Satriano, Cristina, Lin, Yuxi, Zhang, Rongchun, Dulchavsky, Mark, Bhunia, Anirban, Ivanova, Magdalena I., Lee, Young-Ho, La Rosa, Carmelo, Lim, Mi Hee, Ramamoorthy, Ayyalusamy
Published in The Journal of biological chemistry (17.03.2017)
Published in The Journal of biological chemistry (17.03.2017)
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Journal Article
Cholesterol and metal ions in Alzheimer's disease
Lee, Hyuck Jin, Korshavn, Kyle J, Kochi, Akiko, Derrick, Jeffrey S, Lim, Mi Hee
Published in Chemical Society reviews (07.10.2014)
Published in Chemical Society reviews (07.10.2014)
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Journal Article
Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease
Jones, Michael R, Mathieu, Emilie, Dyrager, Christine, Faissner, Simon, Vaillancourt, Zavier, Korshavn, Kyle J, Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Wee Yong, V, Tsutsui, Shigeki, Stys, Peter K, Storr, Tim
Published in Chemical science (Cambridge) (01.08.2017)
Published in Chemical science (Cambridge) (01.08.2017)
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Journal Article
Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives
Korshavn, Kyle J, Jang, Milim, Kwak, Yeon Ju, Kochi, Akiko, Vertuani, Silvia, Bhunia, Anirban, Manfredini, Stefano, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
Published in Scientific reports (10.12.2015)
Published in Scientific reports (10.12.2015)
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Journal Article
A redox switch regulates the structure and function of anti-apoptotic BFL-1
Korshavn, Kyle J, Wales, Thomas E, Bird, Gregory H, Engen, John R, Walensky, Loren D
Published in Nature structural & molecular biology (01.09.2020)
Published in Nature structural & molecular biology (01.09.2020)
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Journal Article
A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms
Derrick, Jeffrey S, Kerr, Richard A, Nam, Younwoo, Oh, Shin Bi, Lee, Hyuck Jin, Earnest, Kaylin G, Suh, Nayoung, Peck, Kristy L, Ozbil, Mehmet, Korshavn, Kyle J, Ramamoorthy, Ayyalusamy, Prabhakar, Rajeev, Merino, Edward J, Shearer, Jason, Lee, Joo-Yong, Ruotolo, Brandon T, Lim, Mi Hee
Published in Journal of the American Chemical Society (25.11.2015)
Published in Journal of the American Chemical Society (25.11.2015)
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Journal Article
A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease
Savelieff, Masha G, Liu, Yuzhong, Senthamarai, Russell R P, Korshavn, Kyle J, Lee, Hyuck Jin, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
Published in Chemical communications (Cambridge, England) (25.05.2014)
Published in Chemical communications (Cambridge, England) (25.05.2014)
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Journal Article
Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation
Jones, Michael R., Dyrager, Christine, Hoarau, Marie, Korshavn, Kyle J., Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Storr, Tim
Published in Journal of inorganic biochemistry (01.05.2016)
Published in Journal of inorganic biochemistry (01.05.2016)
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Journal Article
An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation
Kang, Juhye, Lee, Shin Jung C., Nam, Jung Seung, Lee, Hyuck Jin, Kang, Myeong‐Gyun, Korshavn, Kyle J., Kim, Hyun‐Tak, Cho, Jaeheung, Ramamoorthy, Ayyalusamy, Rhee, Hyun‐Woo, Kwon, Tae‐Hyuk, Lim, Mi Hee
Published in Chemistry : a European journal (31.01.2017)
Published in Chemistry : a European journal (31.01.2017)
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Journal Article
Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter‐Related Pathological Features in Alzheimer's Disease
Lee, Hyuck Jin, Korshavn, Kyle J., Nam, Younwoo, Kang, Juhye, Paul, Thomas J., Kerr, Richard A., Youn, Il Seung, Ozbil, Mehmet, Kim, Kwang S., Ruotolo, Brandon T., Prabhakar, Rajeev, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
Published in Chemistry : a European journal (21.02.2017)
Published in Chemistry : a European journal (21.02.2017)
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Journal Article
Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease
Derrick, Jeffrey S, Kerr, Richard A, Korshavn, Kyle J, McLane, Michael J, Kang, Juhye, Nam, Eunju, Ramamoorthy, Ayyalusamy, Ruotolo, Brandon T, Lim, Mi Hee
Published in Inorganic chemistry (16.05.2016)
Published in Inorganic chemistry (16.05.2016)
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Journal Article
Real-time monitoring of the aggregation of Alzheimer's amyloid-β via 1 H magic angle spinning NMR spectroscopy
Wang, Jian, Yamamoto, Tomoya, Bai, Jia, Cox, Sarah J, Korshavn, Kyle J, Monette, Martine, Ramamoorthy, Ayyalusamy
Published in Chemical communications (Cambridge, England) (20.02.2018)
Published in Chemical communications (Cambridge, England) (20.02.2018)
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Journal Article
Biophysical insights into the membrane interaction of the core amyloid-forming Aβ40 fragment K16-K28 and its role in the pathogenesis of Alzheimer's disease
Bera, Swapna, Korshavn, Kyle J, Kar, Rajiv K, Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Bhunia, Anirban
Published in Physical chemistry chemical physics : PCCP (22.06.2016)
Published in Physical chemistry chemical physics : PCCP (22.06.2016)
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Journal Article
Cholesterol and metal ions in Alzheimer's disease
Lee, Hyuck Jin, Korshavn, Kyle J., Kochi, Akiko, Derrick, Jeffrey S., Lim, Mi Hee
Published in Chemical Society reviews (2014)
Published in Chemical Society reviews (2014)
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Journal Article
Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease
Beck, Michael W., Derrick, Jeffrey S., Suh, Jong‐Min, Kim, Mingeun, Korshavn, Kyle J., Kerr, Richard A., Cho, Woo Jong, Larsen, Scott D., Ruotolo, Brandon T., Ramamoorthy, Ayyalusamy, Lim, Mi Hee
Published in ChemMedChem (22.11.2017)
Published in ChemMedChem (22.11.2017)
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Journal Article
Front Cover: Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease (ChemMedChem 22/2017)
Beck, Michael W., Derrick, Jeffrey S., Suh, Jong‐Min, Kim, Mingeun, Korshavn, Kyle J., Kerr, Richard A., Cho, Woo Jong, Larsen, Scott D., Ruotolo, Brandon T., Ramamoorthy, Ayyalusamy, Lim, Mi Hee
Published in ChemMedChem (22.11.2017)
Published in ChemMedChem (22.11.2017)
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Journal Article