The foundations of immune checkpoint blockade and the ipilimumab approval decennial
Korman, Alan J, Garrett-Thomson, Sarah C, Lonberg, Nils
Published in Nature reviews. Drug discovery (01.07.2022)
Published in Nature reviews. Drug discovery (01.07.2022)
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FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis
Dahan, Rony, Sega, Emanuela, Engelhardt, John, Selby, Mark, Korman, Alan J., Ravetch, Jeffrey V.
Published in Cancer cell (14.09.2015)
Published in Cancer cell (14.09.2015)
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Evolving synergistic combinations of targeted immunotherapies to combat cancer
Melero, Ignacio, Berman, David M, Aznar, M Angela, Korman, Alan J, Pérez Gracia, José Luis, Haanen, John
Published in Nature reviews. Cancer (01.08.2015)
Published in Nature reviews. Cancer (01.08.2015)
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Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology
Selby, Mark J, Engelhardt, John J, Johnston, Robert J, Lu, Li-Sheng, Han, Minhua, Thudium, Kent, Yao, Dapeng, Quigley, Michael, Valle, Jose, Wang, Changyu, Chen, Bing, Cardarelli, Pina M, Blanset, Diann, Korman, Alan J
Published in PloS one (09.09.2016)
Published in PloS one (09.09.2016)
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Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
Galstyan, Anna, Markman, Janet L, Shatalova, Ekaterina S, Chiechi, Antonella, Korman, Alan J, Patil, Rameshwar, Klymyshyn, Dmytro, Tourtellotte, Warren G, Israel, Liron L, Braubach, Oliver, Ljubimov, Vladimir A, Mashouf, Leila A, Ramesh, Arshia, Grodzinski, Zachary B, Penichet, Manuel L, Black, Keith L, Holler, Eggehard, Sun, Tao, Ding, Hui, Ljubimov, Alexander V, Ljubimova, Julia Y
Published in Nature communications (28.08.2019)
Published in Nature communications (28.08.2019)
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Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy
Marciscano, Ariel E, Ghasemzadeh, Ali, Nirschl, Thomas R, Theodros, Debebe, Kochel, Christina M, Francica, Brian J, Muroyama, Yuki, Anders, Robert A, Sharabi, Andrew B, Velarde, Esteban, Mao, Wendy, Chaudhary, Kunal R, Chaimowitz, Matthew G, Wong, John, Selby, Mark J, Thudium, Kent B, Korman, Alan J, Ulmert, David, Thorek, Daniel L J, DeWeese, Theodore L, Drake, Charles G
Published in Clinical cancer research (15.10.2018)
Published in Clinical cancer research (15.10.2018)
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Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
BRAHMER, Julie R, DRAKE, Charles G, GILSON, Marta M, CHANGYU WANG, SELBY, Mark, TAUBE, Janis M, ANDERS, Robert, LIEPING CHEN, KORMAN, Alan J, PARDOLL, Drew M, LOWY, Israel, TOPALIAN, Suzanne L, WOLLNER, Ira, POWDERLY, John D, PICUS, Joel, SHARFMAN, William H, STANKEVICH, Elizabeth, PONS, Alice, SALAY, Theresa M, MCMILLER, Tracee L
Published in Journal of clinical oncology (01.07.2010)
Published in Journal of clinical oncology (01.07.2010)
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Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab
Ramagopal, Udupi A., Liu, Weifeng, Garrett-Thomson, Sarah C., Bonanno, Jeffrey B., Yan, Qingrong, Srinivasan, Mohan, Wong, Susan C., Bell, Alasdair, Mankikar, Shilpa, Rangan, Vangipuram S., Deshpande, Shrikant, Korman, Alan J., Almo, Steven C.
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2017)
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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection
Chew, Glen M, Fujita, Tsuyoshi, Webb, Gabriela M, Burwitz, Benjamin J, Wu, Helen L, Reed, Jason S, Hammond, Katherine B, Clayton, Kiera L, Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I, Hecht, Frederick M, Ostrowski, Mario, Shikuma, Cecilia M, Hansen, Scott G, Maurer, Mark, Korman, Alan J, Deeks, Steven G, Sacha, Jonah B, Ndhlovu, Lishomwa C
Published in PLoS pathogens (01.01.2016)
Published in PLoS pathogens (01.01.2016)
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Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma
Wolchok, Jedd D., Hodi, F. Stephen, Weber, Jeffrey S., Allison, James P., Urba, Walter J., Robert, Caroline, O'Day, Steven J., Hoos, Axel, Humphrey, Rachel, Berman, David M., Lonberg, Nils, Korman, Alan J.
Published in Annals of the New York Academy of Sciences (01.07.2013)
Published in Annals of the New York Academy of Sciences (01.07.2013)
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Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape
Noguchi, Takuro, Ward, Jeffrey P, Gubin, Matthew M, Arthur, Cora D, Lee, Sang Hun, Hundal, Jasreet, Selby, Mark J, Graziano, Robert F, Mardis, Elaine R, Korman, Alan J, Schreiber, Robert D
Published in Cancer immunology research (01.02.2017)
Published in Cancer immunology research (01.02.2017)
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Journal Article
FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis
Dahan, Rony, Sega, Emanuela, Engelhardt, John, Selby, Mark, Korman, Alan J., Ravetch, Jeffrey V.
Published in Cancer cell (12.10.2015)
Published in Cancer cell (12.10.2015)
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BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies
KUHNE, Michelle R, MULVEY, Tanya, COHEN, Lewis J, KORMAN, Alan J, CARDARELLI, Pina M, BELANGER, Blake, CHEN, Sharline, PAN, Chin, COLIN CHONG, FEI CAO, NIEKRO, Wafa, KEMPE, Tom, HENNING, Karla A
Published in Clinical cancer research (15.01.2013)
Published in Clinical cancer research (15.01.2013)
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A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection
Gardiner, David, Lalezari, Jay, Lawitz, Eric, DiMicco, Michael, Ghalib, Rheem, Reddy, K Rajender, Chang, Kyong-Mi, Sulkowski, Mark, Marro, Steven O', Anderson, Jeffrey, He, Bing, Kansra, Vikram, McPhee, Fiona, Wind-Rotolo, Megan, Grasela, Dennis, Selby, Mark, Korman, Alan J, Lowy, Israel
Published in PloS one (22.05.2013)
Published in PloS one (22.05.2013)
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Blockade ofthe negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis
Chang, Katherine C, Burnham, Carey-Ann, Compton, Stephanie M, Rasche, David P, Mazuski, RichardJ, SMcDonough, Jacquelyn, Unsinger, Jacqueline, Korman, Alan J, Green, Jonathan M, Hotchkiss, Richard S
Published in Critical care (London, England) (01.01.2013)
Published in Critical care (London, England) (01.01.2013)
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Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25
Hannani, Dalil, Vétizou, Marie, Enot, David, Rusakiewicz, Sylvie, Chaput, Nathalie, Klatzmann, David, Desbois, Melanie, Jacquelot, Nicolas, Vimond, Nadège, Chouaib, Salem, Mateus, Christine, Allison, James P, Ribas, Antoni, Wolchok, Jedd D, Yuan, Jianda, Wong, Philip, Postow, Michael, Mackiewicz, Andrzej, Mackiewicz, Jacek, Schadendorff, Dirk, Jaeger, Dirk, Zörnig, Inka, Hassel, Jessica, Korman, Alan J, Bahjat, Keith, Maio, Michele, Calabro, Luana, Teng, Michele Wl, Smyth, Mark J, Eggermont, Alexander, Robert, Caroline, Kroemer, Guido, Zitvogel, Laurence
Published in Cell research (01.02.2015)
Published in Cell research (01.02.2015)
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Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
Brahmer, Julie R, Drake, Charles G, Wollner, Ira, Powderly, John D, Picus, Joel, Sharfman, William H, Stankevich, Elizabeth, Pons, Alice, Salay, Theresa M, McMiller, Tracee L, Gilson, Marta M, Wang, Changyu, Selby, Mark, Taube, Janis M, Anders, Robert, Chen, Lieping, Korman, Alan J, Pardoll, Drew M, Lowy, Israel, Topalian, Suzanne L
Published in Journal of clinical oncology (01.02.2023)
Published in Journal of clinical oncology (01.02.2023)
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Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3
Bettini, Maria, Szymczak-Workman, Andrea L, Forbes, Karen, Castellaw, Ashley H, Selby, Mark, Pan, Xiaoyu, Drake, Charles G, Korman, Alan J, Vignali, Dario A A
Published in The Journal of immunology (1950) (01.10.2011)
Published in The Journal of immunology (1950) (01.10.2011)
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TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer
Maas, Ralph Ja, Hoogstad-van Evert, Janneke S, Van der Meer, Jolien Mr, Mekers, Vera, Rezaeifard, Somayeh, Korman, Alan J, de Jonge, Paul Kjd, Cany, Jeannette, Woestenenk, Rob, Schaap, Nicolaas Pm, Massuger, Leon F, Jansen, Joop H, Hobo, Willemijn, Dolstra, Harry
Published in Oncoimmunology (01.01.2020)
Published in Oncoimmunology (01.01.2020)
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