Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans
Groeneveld, Dafna, Pereyra, David, Veldhuis, Zwanida, Adelmeijer, Jelle, Ottens, Petra, Kopec, Anna K., Starlinger, Patrick, Lisman, Ton, Luyendyk, James P.
Published in Blood (14.03.2019)
Published in Blood (14.03.2019)
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Journal Article
Thrombin promotes diet-induced obesity through fibrin-driven inflammation
Kopec, Anna K, Abrahams, Sara R, Thornton, Sherry, Palumbo, Joseph S, Mullins, Eric S, Divanovic, Senad, Weiler, Hartmut, Owens, 3rd, A Phillip, Mackman, Nigel, Goss, Ashley, van Ryn, Joanne, Luyendyk, James P, Flick, Matthew J
Published in The Journal of clinical investigation (01.08.2017)
Published in The Journal of clinical investigation (01.08.2017)
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Journal Article
A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice
Miszta, Adam, Kopec, Anna K., Pant, Asmita, Holle, Lori A., Byrnes, James R., Lawrence, Daniel A., Hansen, Kirk C., Flick, Matthew J., Luyendyk, James P., de Laat, Bas, Wolberg, Alisa S.
Published in Blood (07.05.2020)
Published in Blood (07.05.2020)
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Journal Article
Microphysiological systems in early stage drug development: Perspectives on current applications and future impact
Kopec, Anna K., Yokokawa, Ryuji, Khan, Nasir, Horii, Ikuo, Finley, James E., Bono, Christine P., Donovan, Carol, Roy, Jessica, Harney, Julie, Burdick, Andrew D., Jessen, Bart, Lu, Shuyan, Collinge, Mark, Sadeghian, Ramin Banan, Derzi, Mazin, Tomlinson, Lindsay, Burkhardt, John E.
Published in Journal of toxicological sciences (01.01.2021)
Published in Journal of toxicological sciences (01.01.2021)
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Journal Article
Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury
Rautou, Pierre-Emmanuel, Tatsumi, Kohei, Antoniak, Silvio, Owens, A. Phillip, Sparkenbaugh, Erica, Holle, Lori A, Wolberg, Alisa S, Kopec, Anna K, Pawlinski, Rafal, Luyendyk, James P, Mackman, Nigel
Published in Journal of hepatology (01.01.2016)
Published in Journal of hepatology (01.01.2016)
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Journal Article
Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse
Bates, Melissa A, Akbari, Peyman, Gilley, Kristen N, Wagner, James G, Li, Ning, Kopec, Anna K, Wierenga, Kathryn A, Jackson-Humbles, Daven, Brandenberger, Christina, Holian, Andrij, Benninghoff, Abby D, Harkema, Jack R, Pestka, James J
Published in Frontiers in immunology (12.09.2018)
Published in Frontiers in immunology (12.09.2018)
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Journal Article
Hepatocyte tissue factor activates the coagulation cascade in mice
Sullivan, Bradley P., Kopec, Anna K., Joshi, Nikita, Cline, Holly, Brown, Juliette A., Bishop, Stephanie C., Kassel, Karen M., Rockwell, Cheryl, Mackman, Nigel, Luyendyk, James P.
Published in Blood (07.03.2013)
Published in Blood (07.03.2013)
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Journal Article
Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium
Thompson, Chad M, Proctor, Deborah M, Haws, Laurie C, Hébert, Charles D, Grimes, Sheila D, Shertzer, Howard G, Kopec, Anna K, Hixon, J Gregory, Zacharewski, Timothy R, Harris, Mark A
Published in Toxicological sciences (01.09.2011)
Published in Toxicological sciences (01.09.2011)
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Journal Article
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury
Joshi, Nikita, Kopec, Anna K, Towery, Keara, Williams, Kurt J, Luyendyk, James P
Published in The Journal of pharmacology and experimental therapeutics (01.06.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2014)
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Journal Article
Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water
KOPEC, Anna K, KIM, Suntae, FORGACS, Agnes L, ZACHAREWSKI, Timothy R, PROCTOR, Deborah M, HARRIS, Mark A, HAWS, Laurie C, THOMPSON, Chad M
Published in Toxicology and applied pharmacology (15.02.2012)
Published in Toxicology and applied pharmacology (15.02.2012)
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Journal Article
Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice
Kopec, Anna K, Boverhof, Darrell R, Nault, Rance, Harkema, Jack R, Tashiro, Colleen, Potter, Dave, Sharratt, Bonnie, Chittim, Brock, Zacharewski, Timothy R
Published in Toxicological sciences (01.10.2013)
Published in Toxicological sciences (01.10.2013)
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Journal Article
Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice
Kopec, Anna K., Burgoon, Lyle D., Ibrahim-Aibo, Daher, Burg, Ashley R., Lee, Andrea W., Tashiro, Colleen, Potter, Dave, Sharratt, Bonnie, Harkema, Jack R., Rowlands, J. Craig, Budinsky, Robert A., Zacharewski, Timothy R.
Published in Toxicological sciences (01.11.2010)
Published in Toxicological sciences (01.11.2010)
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Journal Article
Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice
Saini, Yogesh, Proper, Steven P, Dornbos, Peter, Greenwood, Krista K, Kopec, Anna K, Lynn, Scott G, Grier, Elizabeth, Burgoon, Lyle D, Zacharewski, Timothy R, Thomas, Russell S, Harkema, Jack R, LaPres, John J
Published in PloS one (30.09.2015)
Published in PloS one (30.09.2015)
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Journal Article
Role of the blood coagulation cascade in hepatic fibrosis
Pant, Asmita, Kopec, Anna K, Luyendyk, James P
Published in American journal of physiology: Gastrointestinal and liver physiology (01.08.2018)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.08.2018)
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Journal Article
PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: Comparative toxicogenomic effects of dioxin and non-dioxin-like ligands
Kopec, Anna K., Burgoon, Lyle D., Ibrahim-Aibo, Daher, Mets, Bryan D., Tashiro, Colleen, Potter, Dave, Sharratt, Bonnie, Harkema, Jack R., Zacharewski, Timothy R.
Published in Toxicology and applied pharmacology (15.03.2010)
Published in Toxicology and applied pharmacology (15.03.2010)
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Journal Article
Towards in vitro models for reducing or replacing the use of animals in drug testing
Stresser, David M, Kopec, Anna K, Hewitt, Philip, Hardwick, Rhiannon N, Van Vleet, Terry R, Mahalingaiah, Prathap Kumar S, O'Connell, Denice, Jenkins, Gary J, David, Rhiannon, Graham, Jessica, Lee, Donna, Ekert, Jason, Fullerton, Aaron, Villenave, Remi, Bajaj, Piyush, Gosset, James R, Ralston, Sherry L, Guha, Manti, Amador-Arjona, Alejandro, Khan, Kainat, Agarwal, Saket, Hasselgren, Catrin, Wang, Xiaoting, Adams, Khary, Kaushik, Gaurav, Raczynski, Arkadiusz, Homan, Kimberly A
Published in Nature biomedical engineering (01.08.2024)
Published in Nature biomedical engineering (01.08.2024)
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Journal Article
Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αM β2 integrin-dependent upregulation of Mmp12
Kopec, Anna K, Joshi, Nikita, Cline-Fedewa, Holly, Wojcicki, Anna V, Ray, Jessica L, Sullivan, Bradley P, Froehlich, John E, Johnson, Brendan F, Flick, Matthew J, Luyendyk, James P
Published in Journal of hepatology (01.04.2017)
Published in Journal of hepatology (01.04.2017)
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Journal Article
The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary
Baker, Thomas K, Van Vleet, Terry R, Mahalingaiah, Prathap Kumar, Grandhi, Taraka Sai Pavan, Evers, Raymond, Ekert, Jason, Gosset, James R, Chacko, Silvi A, Kopec, Anna K
Published in Drug metabolism and disposition (01.03.2024)
Published in Drug metabolism and disposition (01.03.2024)
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Journal Article
Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury
Poole, Lauren G., Kopec, Anna K., Groeneveld, Dafna J., Pant, Asmita, Baker, Kevin S., Cline-Fedewa, Holly M., Flick, Matthew J., Luyendyk, James P.
Published in Blood (06.05.2021)
Published in Blood (06.05.2021)
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Journal Article