Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2)
Serle, Janet B., Katz, L. Jay, McLaurin, Eugene, Heah, Theresa, Ramirez-Davis, Nancy, Usner, Dale W., Novack, Gary D., Kopczynski, Casey C.
Published in American journal of ophthalmology (01.02.2018)
Published in American journal of ophthalmology (01.02.2018)
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Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension
Lewis, Richard A, Levy, Brian, Ramirez, Nancy, C Kopczynski, Casey, Usner, Dale W, Novack, Gary D
Published in British journal of ophthalmology (01.03.2016)
Published in British journal of ophthalmology (01.03.2016)
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Double-masked, Randomized, Dose–Response Study of AR-13324 versus Latanoprost in Patients with Elevated Intraocular Pressure
Bacharach, Jason, MD, Dubiner, Harvey B., MD, Levy, Brian, OD, MS, Kopczynski, Casey C., PhD, Novack, Gary D., PhD
Published in Ophthalmology (Rochester, Minn.) (01.02.2015)
Published in Ophthalmology (Rochester, Minn.) (01.02.2015)
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Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits
Kiel, Jeffrey W, Kopczynski, Casey C
Published in Journal of ocular pharmacology and therapeutics (01.04.2015)
Published in Journal of ocular pharmacology and therapeutics (01.04.2015)
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Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms
Ren, Ruiyi, Li, Guorong, Le, Thuy Duong, Kopczynski, Casey, Stamer, W Daniel, Gong, Haiyan
Published in Investigative ophthalmology & visual science (01.11.2016)
Published in Investigative ophthalmology & visual science (01.11.2016)
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Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes
Li, Guorong, Mukherjee, Dibyendu, Navarro, Iris, Ashpole, Nicole E., Sherwood, Joseph M., Chang, Jinlong, Overby, Darryl R., Yuan, Fan, Gonzalez, Pedro, Kopczynski, Casey C., Farsiu, Sina, Stamer, W. Daniel
Published in European journal of pharmacology (15.09.2016)
Published in European journal of pharmacology (15.09.2016)
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Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2
Asrani, Sanjay, Bacharach, Jason, Holland, Edward, McKee, Hayley, Sheng, Huan, Lewis, Richard A., Kopczynski, Casey C., Heah, Theresa
Published in Advances in therapy (01.04.2020)
Published in Advances in therapy (01.04.2020)
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Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution: Rho Kinase Elevated IOP Treatment Trial (ROCKET-2)
Kahook, Malik Y., Serle, Janet B., Mah, Francis S., Kim, Terry, Raizman, Michael B., Heah, Theresa, Ramirez-Davis, Nancy, Kopczynski, Casey C., Usner, Dale W., Novack, Gary D.
Published in American journal of ophthalmology (01.04.2019)
Published in American journal of ophthalmology (01.04.2019)
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Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis
Li, Guorong, Lee, Chanyoung, Read, A Thomas, Wang, Ke, Ha, Jungmin, Kuhn, Megan, Navarro, Iris, Cui, Jenny, Young, Katherine, Gorijavolu, Rahul, Sulchek, Todd, Kopczynski, Casey, Farsiu, Sina, Samples, John, Challa, Pratap, Ethier, C Ross, Stamer, W Daniel
Published in eLife (30.03.2021)
Published in eLife (30.03.2021)
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Consensus recommendations for trabecular meshwork cell isolation, characterization and culture
Keller, Kate E., Bhattacharya, Sanjoy K., Borrás, Theresa, Brunner, Thomas M., Chansangpetch, Sunee, Clark, Abbott F., Dismuke, W. Michael, Du, Yiqin, Elliott, Michael H., Ethier, C. Ross, Faralli, Jennifer A., Freddo, Thomas F., Fuchshofer, Rudolf, Giovingo, Michael, Gong, Haiyan, Gonzalez, Pedro, Huang, Alex, Johnstone, Murray A., Kaufman, Paul L., Kelley, Mary J., Knepper, Paul A., Kopczynski, Casey C., Kuchtey, John G., Kuchtey, Rachel W., Kuehn, Markus H., Lieberman, Raquel L., Lin, Shan C., Liton, Paloma, Liu, Yutao, Lütjen-Drecoll, Elke, Mao, Weiming, Masis-Solano, Marisse, McDonnell, Fiona, McDowell, Colleen M., Overby, Darryl R., Pattabiraman, Padmanabhan P., Raghunathan, Vijay K., Rao, P. Vasanth, Rhee, Douglas J., Chowdhury, Uttio Roy, Russell, Paul, Samples, John R., Schwartz, Donald, Stubbs, Evan B., Tamm, Ernst R., Tan, James C., Toris, Carol B., Torrejon, Karen Y., Vranka, Janice A., Wirtz, Mary K., Yorio, Thomas, Zhang, Jie, Zode, Gulab S., Fautsch, Michael P., Peters, Donna M., Acott, Ted S., Stamer, W. Daniel
Published in Experimental eye research (01.06.2018)
Published in Experimental eye research (01.06.2018)
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Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma
Lin, Cheng-Wen, Sherman, Bryan, Moore, Lori A, Laethem, Carmen L, Lu, Da-Wen, Pattabiraman, Padmanabhan P, Rao, Ponugoti Vasantha, deLong, Mitchell A, Kopczynski, Casey C
Published in Journal of ocular pharmacology and therapeutics (01.03.2018)
Published in Journal of ocular pharmacology and therapeutics (01.03.2018)
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The Effects of Netarsudil Ophthalmic Solution on Aqueous Humor Dynamics in a Randomized Study in Humans
Kazemi, Arash, McLaren, Jay W, Kopczynski, Casey C, Heah, Theresa G, Novack, Gary D, Sit, Arthur J
Published in Journal of ocular pharmacology and therapeutics (01.06.2018)
Published in Journal of ocular pharmacology and therapeutics (01.06.2018)
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Phase 3 Clinical Trial Comparing the Safety and Efficacy of Netarsudil to Ripasudil in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: Japan Rho Kinase Elevated Intraocular Pressure Treatment Trial (J-ROCKET)
Araie, Makoto, Sugiyama, Kazuhisa, Aso, Kenji, Kanemoto, Koji, Iwata, Ryo, Hollander, David A., Senchyna, Michelle, Kopczynski, Casey C.
Published in Advances in therapy (01.10.2023)
Published in Advances in therapy (01.10.2023)
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Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma
Sturdivant, Jill M., Royalty, Susan M., Lin, Cheng-Wen, Moore, Lori A., Yingling, Jeffrey D., Laethem, Carmen L., Sherman, Bryan, Heintzelman, Geoffrey R., Kopczynski, Casey C., deLong, Mitchell A.
Published in Bioorganic & medicinal chemistry letters (15.05.2016)
Published in Bioorganic & medicinal chemistry letters (15.05.2016)
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Emerging trabecular outflow drugs
Kopczynski, Casey C, Epstein, David L
Published in Journal of ocular pharmacology and therapeutics (01.03.2014)
Published in Journal of ocular pharmacology and therapeutics (01.03.2014)
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Journal Article
Once-Daily Netarsudil Versus Twice-Daily Timolol in Patients With Elevated Intraocular Pressure: The Randomized Phase 3 ROCKET-4 Study
Khouri, Albert S., Serle, Janet B., Bacharach, Jason, Usner, Dale W., Lewis, Richard A., Braswell, Puiwah, Kopczynski, Casey C., Heah, Theresa, Bacharach, Jason, Benza, Robert, Boyle, John W., Butler, Michelle, Cacioppo, Leonard Robert, Cardona, Jose F., Colborn, Valerie A., Day, Douglas G., Douglass, David T., El-Harazi, Sherif M., Ghate, Deepta, Hartman, Carl, Haverly, Robert F., Katzman, Barry, Kim, Max, Koo, Edward Y., Korenfeld, Michael S., Kwapiszeski, Bradley, Lane, Lydia, Lin, Christopher, Logan, Andrew Gardner, Lozier, Jeffrey Raymond, McQuirter, Henry, Mundorf, Thomas K., Olander, Kenneth, Ou, Richard J., Panzo, Gregory J., Peace, James H., Protzko, Eugene E., Ritch, Robert, Sall, Kenneth, Schechter, Barry A., Seltzer, Samuel Eric, Shah, Pankajkumar G., Sharpe, Elizabeth, Lee Shettle, Philip, Shulman, David G., Singh, Inder Paul, Smith, Stacy R., Smith, Stephen E., Smyth-Medina, Robert John, Sorenson, Robert C., Sturm, Richard, Sulkowski, Gregory M., Sutton, James D., Tepedino, Michael, Tsai, Julie, Tubbs, Carl B., Tukel, David B., Walters, Thomas Richard, Wirta, David L.
Published in American journal of ophthalmology (01.08.2019)
Published in American journal of ophthalmology (01.08.2019)
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PHASE 2 RANDOMIZED STUDY (ORION-1) OF A NOVEL, BIODEGRADABLE DEXAMETHASONE IMPLANT (AR-1105) FOR THE TREATMENT OF MACULAR EDEMA DUE TO CENTRAL OR BRANCH RETINAL VEIN OCCLUSION
Singer, Michael A, Boyer, David S, Williams, Stuart, McKee, Hayley, Kerr, Kevin, Pegoraro, Tyler, Trevino, Leo, Kopczynski, Casey C, Hollander, David A
Published in Retina (Philadelphia, Pa.) (01.01.2023)
Published in Retina (Philadelphia, Pa.) (01.01.2023)
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Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Three-Month Data from a Randomized Phase 3 Trial
Asrani, Sanjay, Robin, Alan L., Serle, Janet B., Lewis, Richard A., Usner, Dale W., Kopczynski, Casey C., Heah, Theresa, Ackerman, Stacey L., Alpern, Louis M., Asrani, Sanjay, Bashford, Kent, Bluestein, Ettaleah C., Boyce, James D., Branch, James D., Brubaker, Jacob W., Christie, William C., Cohen, John S., Collins, Nicole M., Corin, Scott M., Daynes, Todd Ellsworth, Depenbusch, Michael, Dixon, El-Roy, Duzman, Eran, Flowers, Brian E., Flynn, William J., Fong, Raymond, Gira, Joseph P., Goldberg, Damien F., Greene, Brennan, Han, Scott B., Henderson, Thomas T., Jerkins, Gary, Jong, Kevin Y., Katzen, Lawrence B., Khemsara, Vickas, Klugo, Karen L., Kozlovsky, John F., Leonardo, Donna, Liu, Yao, LoBue, Thomas D., Luchs, Jodi Ian, Malhotra, Ranjan P., Mays, Andrew, McLaurin, Eugene B., McMenemy, Matthew G., Modi, Satish, Moroi, Sayoko, Mulaney, Jay, Nagi, Kundandeep, Nicolau, John, Parikh, Mihir, Patel, Jay R., Peplinski, Lee S., Perez, Bernard R., Piltz-Seymour, Jody, Sadri, Ehsan, Saltzmann, Robert M., Schenker, Howard I., Swanic, Matthew J., Tekwani, Navin, Teymoorian, Savak, Thomas, Justus W., Tyson, Farrell C., Vold, Stephen, Weiss, Mark J., Zaman, Fiaz
Published in American journal of ophthalmology (01.11.2019)
Published in American journal of ophthalmology (01.11.2019)
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Journal Article
Pooled Efficacy and Safety Profile of Netarsudil Ophthalmic Solution 0.02% in Patients With Open-angle Glaucoma or Ocular Hypertension
Singh, Inder P, Fechtner, Robert D, Myers, Jonathan S, Kim, Terry, Usner, Dale W, McKee, Hayley, Sheng, Huan, Lewis, Richard A, Heah, Theresa, Kopczynski, Casey C
Published in Journal of glaucoma (01.10.2020)
Published in Journal of glaucoma (01.10.2020)
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