Barcoded Asaia bacteria enable mosquito in vivo screens and identify novel systemic insecticides and inhibitors of malaria transmission
Sturm, Angelika, Vos, Martijn W, Henderson, Rob, Eldering, Maarten, Koolen, Karin M J, Sheshachalam, Avinash, Favia, Guido, Samby, Kirandeep, Herreros, Esperanza, Dechering, Koen J
Published in PLoS biology (20.12.2021)
Published in PLoS biology (20.12.2021)
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Salinomycin and other ionophores as a new class of antimalarial drugs with transmission-blocking activity
D'Alessandro, Sarah, Corbett, Yolanda, Ilboudo, Denise P, Misiano, Paola, Dahiya, Nisha, Abay, Solomon M, Habluetzel, Annette, Grande, Romualdo, Gismondo, Maria R, Dechering, Koen J, Koolen, Karin M J, Sauerwein, Robert W, Taramelli, Donatella, Basilico, Nicoletta, Parapini, Silvia
Published in Antimicrobial agents and chemotherapy (01.09.2015)
Published in Antimicrobial agents and chemotherapy (01.09.2015)
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Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening
Miglianico, Marie, Bolscher, Judith M., Vos, Martijn W., Koolen, Karin J. M., de Bruijni, Marloes, Rajagopal, Deeya S., Chen, Emily, Kiczun, Michael, Gray, David, Campo, Brice, Sauerwein, Robert W., Dechering, Koen J.
Published in Communications biology (23.02.2023)
Published in Communications biology (23.02.2023)
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A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages
Marin-Mogollon, Catherin, Salman, Ahmed M, Koolen, Karin M J, Bolscher, Judith M, van Pul, Fiona J A, Miyazaki, Shinya, Imai, Takashi, Othman, Ahmad Syibli, Ramesar, Jai, van Gemert, Geert-Jan, Kroeze, Hans, Chevalley-Maurel, Severine, Franke-Fayard, Blandine, Sauerwein, Robert W, Hill, Adrian V S, Dechering, Koen J, Janse, Chris J, Khan, Shahid M
Published in Frontiers in cellular and infection microbiology (16.04.2019)
Published in Frontiers in cellular and infection microbiology (16.04.2019)
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Novel pantothenate derivatives for anti-malarial chemotherapy
Pett, Helmi E, Jansen, Patrick A M, Hermkens, Pedro H H, Botman, Peter N M, Beuckens-Schortinghuis, Christien A, Blaauw, Richard H, Graumans, Wouter, van de Vegte-Bolmer, Marga, Koolen, Karin M J, Rutjes, Floris P J T, Dechering, Koen J, Sauerwein, Robert W, Schalkwijk, Joost
Published in Malaria journal (18.04.2015)
Published in Malaria journal (18.04.2015)
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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
Kato, Nobutaka, Comer, Eamon, Sakata-Kato, Tomoyo, Sharma, Arvind, Sharma, Manmohan, Maetani, Micah, Bastien, Jessica, Brancucci, Nicolas M., Bittker, Joshua A., Corey, Victoria, Clarke, David, Derbyshire, Emily R., Dornan, Gillian L., Duffy, Sandra, Eckley, Sean, Itoe, Maurice A., Koolen, Karin M. J., Lewis, Timothy A., Lui, Ping S., Lukens, Amanda K., Lund, Emily, March, Sandra, Meibalan, Elamaran, Meier, Bennett C., McPhail, Jacob A., Mitasev, Branko, Moss, Eli L., Sayes, Morgane, Van Gessel, Yvonne, Wawer, Mathias J., Yoshinaga, Takashi, Zeeman, Anne-Marie, Avery, Vicky M., Bhatia, Sangeeta N., Burke, John E., Catteruccia, Flaminia, Clardy, Jon C., Clemons, Paul A., Dechering, Koen J., Duvall, Jeremy R., Foley, Michael A., Gusovsky, Fabian, Kocken, Clemens H. M., Marti, Matthias, Morningstar, Marshall L., Munoz, Benito, Neafsey, Daniel E., Sharma, Amit, Winzeler, Elizabeth A., Wirth, Dyann F., Scherer, Christina A., Schreiber, Stuart L.
Published in Nature (London) (20.10.2016)
Published in Nature (London) (20.10.2016)
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Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases
Miglianico, Marie, Eldering, Maarten, Slater, Hannah, Ferguson, Neil, Ambrose, Pauline, Lees, Rosemary S., Koolen, Karin M. J., Pruzinova, Katerina, Jancarova, Magdalena, Volf, Petr, Koenraadt, Constantianus J. M., Duerr, Hans-Peter, Trevitt, Graham, Yang, Baiyuan, Chatterjee, Arnab K., Wisler, John, Sturm, Angelika, Bousema, Teun, Sauerwein, Robert W., Schultz, Peter G., Tremblay, Matthew S., Dechering, Koen J.
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2018)
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Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum
Schalkwijk, Joost, Allman, Erik L, Jansen, Patrick A M, de Vries, Laura E, Verhoef, Julie M J, Jackowski, Suzanne, Botman, Peter N M, Beuckens-Schortinghuis, Christien A, Koolen, Karin M J, Bolscher, Judith M, Vos, Martijn W, Miller, Karen, Reeves, Stacy A, Pett, Helmi, Trevitt, Graham, Wittlin, Sergio, Scheurer, Christian, Sax, Sibylle, Fischli, Christoph, Angulo-Barturen, Iñigo, Jiménez-Diaz, Mariá Belén, Josling, Gabrielle, Kooij, Taco W A, Bonnert, Roger, Campo, Brice, Blaauw, Richard H, Rutjes, Floris P J T, Sauerwein, Robert W, Llinás, Manuel, Hermkens, Pedro H H, Dechering, Koen J
Published in Science translational medicine (18.09.2019)
Published in Science translational medicine (18.09.2019)
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A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes
Vos, Martijn W., Stone, Will J. R., Koolen, Karin M., van Gemert, Geert-Jan, van Schaijk, Ben, Leroy, Didier, Sauerwein, Robert W., Bousema, Teun, Dechering, Koen J.
Published in Scientific reports (21.12.2015)
Published in Scientific reports (21.12.2015)
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Modelling mosquito infection at natural parasite densities identifies drugs targeting EF2, PI4K or ATP4 as key candidates for interrupting malaria transmission
Dechering, Koen J., Duerr, Hans-Peter, Koolen, Karin M. J., Gemert, Geert-Jan van, Bousema, Teun, Burrows, Jeremy, Leroy, Didier, Sauerwein, Robert W.
Published in Scientific reports (15.12.2017)
Published in Scientific reports (15.12.2017)
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An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines
Miura, Kazutoyo, Stone, Will J R, Koolen, Karin M, Deng, Bingbing, Zhou, Luwen, van Gemert, Geert-Jan, Locke, Emily, Morin, Merribeth, Bousema, Teun, Sauerwein, Robert W, Long, Carole A, Dechering, Koen J
Published in Malaria journal (09.09.2016)
Published in Malaria journal (09.09.2016)
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Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out
Dechering, Koen J., Timmerman, Martijn, Rensen, Kim, Koolen, Karin M.J., Honarnejad, Saman, Vos, Martijn W., Huijs, Tonnie, Henderson, Rob W.M., Chenu, Elodie, Laleu, Benoît, Montefiore, Bailey C., Segall, Matthew D., Mills, James E.J., Guantai, Eric M., Duffy, James, Duffey, Maëlle
Published in SLAS discovery (01.09.2022)
Published in SLAS discovery (01.09.2022)
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Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
de Vries, Laura E., Jansen, Patrick A. M., Barcelo, Catalina, Munro, Justin, Verhoef, Julie M. J., Pasaje, Charisse Flerida A., Rubiano, Kelly, Striepen, Josefine, Abla, Nada, Berning, Luuk, Bolscher, Judith M., Demarta-Gatsi, Claudia, Henderson, Rob W. M., Huijs, Tonnie, Koolen, Karin M. J., Tumwebaze, Patrick K., Yeo, Tomas, Aguiar, Anna C. C., Angulo-Barturen, Iñigo, Churchyard, Alisje, Baum, Jake, Fernández, Benigno Crespo, Fuchs, Aline, Gamo, Francisco-Javier, Guido, Rafael V. C., Jiménez-Diaz, María Belén, Pereira, Dhelio B., Rochford, Rosemary, Roesch, Camille, Sanz, Laura M., Trevitt, Graham, Witkowski, Benoit, Wittlin, Sergio, Cooper, Roland A., Rosenthal, Philip J., Sauerwein, Robert W., Schalkwijk, Joost, Hermkens, Pedro H. H., Bonnert, Roger V., Campo, Brice, Fidock, David A., Llinás, Manuel, Niles, Jacquin C., Kooij, Taco W. A., Dechering, Koen J.
Published in Nature communications (20.04.2022)
Published in Nature communications (20.04.2022)
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Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues
Vallone, Alessandra, D'Alessandro, Sarah, Brogi, Simone, Brindisi, Margherita, Chemi, Giulia, Alfano, Gloria, Lamponi, Stefania, Lee, Soon Goo, Jez, Joseph M., Koolen, Karin J.M., Dechering, Koen J., Saponara, Simona, Fusi, Fabio, Gorelli, Beatrice, Taramelli, Donatella, Parapini, Silvia, Caldelari, Reto, Campiani, Giuseppe, Gemma, Sandra, Butini, Stefania
Published in European journal of medicinal chemistry (25.04.2018)
Published in European journal of medicinal chemistry (25.04.2018)
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Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl) furan-2-yl]-N-Rpiperidin-4-yl)methyllmethanamine (MMV019918) and analogues
Vallone, Alessandra, D'Alessandro, Sarah, Brogi, Simone, Brindisi, Margherita, Chemi, Giulia, Alfano, Gloria, Lamponi, Stefania, Lee, Soon Goo, Jez, Joseph M., Koolen, Karin J. M., Dechering, Koen J., Saponara, Simona, Fusi, Fabio, Gorelli, Beatrice, Taramelli, Donatella, Parapini, Silvia, Caldelari, Reto, Campiani, Giuseppe, Gemma, Sandra, Butini, Stefania
Published in European journal of medicinal chemistry (25.04.2018)
Published in European journal of medicinal chemistry (25.04.2018)
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Journal Article
Antimalarial pantothenamide metabolites target acetyl-CoA synthesis in Plasmodium falciparum
Schalkwijk, Joost, Allman, Erik L, Patrick Am Jansen, De Vries, Laura E, Jackowski, Suzanne, Botman, Peter Nm, Beuckens-Schortinghuis, Christien A, Koolen, Karin M, Bolscher, Judith M, Vos, Martijn W, Miller, Karen, Reeves, Stacey, Pett, Helmi, Trevitt, Graham, Wittlin, Sergio, Scheurer, Christian, Sax, Sibylle, Fischli, Cristophe, Josling, Gabrielle, Taco Wa Kooij, Bonnert, Roger, Campo, Brice, Blaauw, Richard H, Rutjes, Floris Pjt, Sauerwein, Robert, Llinas, Manuel, Pedro Hh Hermkens, Dechering, Koen J
Published in bioRxiv (12.02.2018)
Published in bioRxiv (12.02.2018)
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