Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy
Ranjbarvaziri, Sara, Kooiker, Kristina B., Ellenberger, Mathew, Fajardo, Giovanni, Zhao, Mingming, Vander Roest, Alison Schroer, Woldeyes, Rahel A., Koyano, Tiffany T., Fong, Robyn, Ma, Ning, Tian, Lei, Traber, Gavin M., Chan, Frandics, Perrino, John, Reddy, Sushma, Chiu, Wah, Wu, Joseph C., Woo, Joseph Y., Ruppel, Kathleen M., Spudich, James A., Snyder, Michael P., Contrepois, Kévin, Bernstein, Daniel
Published in Circulation (New York, N.Y.) (23.11.2021)
Published in Circulation (New York, N.Y.) (23.11.2021)
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β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
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Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C
Stern, Joshua A., Rivas, Victor N., Kaplan, Joanna L., Ueda, Yu, Oldach, Maureen S., Ontiveros, Eric S., Kooiker, Kristina B., van Dijk, Sabine J., Harris, Samantha P.
Published in Scientific reports (26.06.2023)
Published in Scientific reports (26.06.2023)
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Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts
Powers, Joseph D, Kooiker, Kristina B, Mason, Allison B, Teitgen, Abigail E, Flint, Galina V, Tardiff, Jil C, Schwartz, Steven D, McCulloch, Andrew D, Regnier, Michael, Davis, Jennifer, Moussavi-Harami, Farid
Published in JCI insight (15.10.2020)
Published in JCI insight (15.10.2020)
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The effect of small molecule myosin modulators on ATP turnover in pig cardiac HMM using stopped flow spectroscopy
Kooiker, Kristina B., Mohran, Saffie, Mahoney-Schaefer, Max, Freeman, Jeremy, Geeves, Michael A., Regnier, Michael, Moussavi-Harami, Farid
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
Machine learning meets Monte Carlo methods for models of muscle's molecular machinery to classify mutations
Asencio, Anthony, Malingen, Sage, Kooiker, Kristina B, Powers, Joseph D, Davis, Jennifer, Daniel, Thomas, Moussavi-Harami, Farid
Published in The Journal of general physiology (01.05.2023)
Published in The Journal of general physiology (01.05.2023)
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Calcium has a direct effect on thick filament activation in porcine myocardium
Mohran, Saffie, McMillen, Timothy S, Mandrycky, Christian, Tu, An-Yue, Kooiker, Kristina B, Qian, Wenjing, Neys, Stephanie, Osegueda, Brayan, Moussavi-Harami, Farid, Irving, Thomas C, Regnier, Michael, Ma, Weikang
Published in The Journal of general physiology (04.11.2024)
Published in The Journal of general physiology (04.11.2024)
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Journal Article
The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca2+]
Turner, Kyrah L., Vander Top, Blake J., Kooiker, Kristina B., Mohran, Saffie, Mandrycky, Christian, McMillen, Tim, Regnier, Michael, Irving, Thomas C., Ma, Weikang, Tanner, Bertrand C. W.
Published in The Journal of physiology (01.10.2024)
Published in The Journal of physiology (01.10.2024)
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Journal Article
MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy
Steczina, Sonette, Mohran, Saffie, Bailey, Logan R.J., McMillen, Timothy S., Kooiker, Kristina B., Wood, Neil B., Davis, Jennifer, Previs, Michael J., Olivotto, Iacopo, Pioner, Josè Manuel, Geeves, Michael A., Poggesi, Corrado, Regnier, Michael
Published in Journal of molecular and cellular cardiology (01.06.2024)
Published in Journal of molecular and cellular cardiology (01.06.2024)
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Journal Article
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
Adhikari, Arjun S., Kooiker, Kristina B., Sarkar, Saswata S., Liu, Chao, Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Cell reports (Cambridge) (13.12.2016)
Published in Cell reports (Cambridge) (13.12.2016)
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Journal Article
Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle
Kooiker, Kristina B., Mohran, Saffie, Turner, Kyrah L., Ma, Weikang, Martinson, Amy, Flint, Galina, Qi, Lin, Gao, Chengqian, Zheng, Yahan, McMillen, Timothy S., Mandrycky, Christian, Mahoney-Schaefer, Max, Freeman, Jeremy C., Costales Arenas, Elijah Gabriela, Tu, An-Yu, Irving, Thomas C., Geeves, Michael A., Tanner, Bertrand C.W., Regnier, Michael, Davis, Jennifer, Moussavi-Harami, Farid
Published in Circulation research (18.08.2023)
Published in Circulation research (18.08.2023)
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4HNE Impairs Myocardial Bioenergetics in Congenital Heart Disease-Induced Right Ventricular Failure
Hwang, HyunTae V., Sandeep, Nefthi, Paige, Sharon L., Ranjbarvaziri, Sara, Hu, Dong-Qing, Zhao, Mingming, Lan, Ingrid S., Coronado, Michael, Kooiker, Kristina B., Wu, Sean M., Fajardo, Giovanni, Bernstein, Daniel, Reddy, Sushma
Published in Circulation (New York, N.Y.) (27.10.2020)
Published in Circulation (New York, N.Y.) (27.10.2020)
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Journal Article
Elucidating the mechanism of Danicamtiv on force, kinetics, and myosin structure and function
Kooiker, Kristina B., Mohran, Saffie, Ma, Weikang, Flint, Galina V., Kao, Kerry Y., Qi, Lin, McMillen, Timothy, Neys, Stephanie, Mandrycky, Christian, Irving, Thomas C., Geeves, Michael A., Regnier, Michael, Moussavi-Harami, Farid
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation
van Dijk, Sabine J., Kooiker, Kristina B., Napierski, Nathaniel C., Touma, Katia D., Mazzalupo, Stacy, Harris, Samantha P.
Published in Journal of molecular and cellular cardiology (01.06.2018)
Published in Journal of molecular and cellular cardiology (01.06.2018)
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miR-21 is associated with fibrosis and right ventricular failure
Reddy, Sushma, Hu, Dong-Qing, Zhao, Mingming, Blay, Jr, Eddie, Sandeep, Nefthi, Ong, Sang-Ging, Jung, Gwanghyun, Kooiker, Kristina B, Coronado, Michael, Fajardo, Giovanni, Bernstein, Daniel
Published in JCI insight (04.05.2017)
Published in JCI insight (04.05.2017)
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Journal Article
The effect of small molecule myosin inhibitors on ATP cycling in porcine cardiac muscle using stopped-flow spectroscopy and in vitro motility
Mahoney-Schaefer, Max, Kooiker, Kristina B., Mohran, Saffie, Flint, Galina V., Regnier, Michael, Moussavi-Harami, Farid
Published in Biophysical journal (08.02.2024)
Published in Biophysical journal (08.02.2024)
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Journal Article
The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and Ca2
Turner, Kyrah L, Vander Top, Blake J, Kooiker, Kristina B, Mohran, Saffie, Mandrycky, Christian, McMillen, Tim, Regnier, Michael, Irving, Thomas C, Ma, Weikang, Tanner, Bertrand C W
Published in The Journal of physiology (01.10.2024)
Published in The Journal of physiology (01.10.2024)
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Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency
Bretherton, Ross C, Reichardt, Isabella M, Zabrecky, Kristin A, Goldstein, Alex J, Bailey, Logan R J, Bugg, Darrian, McMillen, Timothy S, Kooiker, Kristina B, Flint, Galina V, Martinson, Amy, Gunaje, Jagdambika, Koser, Franziska, Plaster, Elizabeth, Linke, Wolfgang A, Regnier, Michael, Moussavi-Harami, Farid, Sniadecki, Nathan J, DeForest, Cole A, Davis, Jennifer
Published in bioRxiv : the preprint server for biology (23.01.2023)
Published in bioRxiv : the preprint server for biology (23.01.2023)
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Journal Article
Decoupling calcium-dependent thin-filament activation from thick-filament activation in porcine myocardium
Mohran, Saffie, Mandrycky, Christian, Tu, An-yue, McMillen, Tim, Kooiker, Kristina B., Qian, Wenjing, Irving, Thomas C., Regnier, Michael, Ma, Weikang
Published in Biophysical journal (08.02.2024)
Published in Biophysical journal (08.02.2024)
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