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Published in Scientific reports (05.06.2014)
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Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia
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FLT3-ITD allelic ratio and HLF expression predict FLT3 inhibitor efficacy in adult AML
Kivioja, Jarno, Malani, Disha, Kumar, Ashwini, Kontro, Mika, Parsons, Alun, Kallioniemi, Olli, Heckman, Caroline A.
Published in Scientific reports (07.12.2021)
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Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition
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Published in Leukemia (01.12.2020)
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KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia
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Published in Leukemia (01.10.2020)
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Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia
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Published in Haematologica (Roma) (01.07.2023)
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Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AML
Karjalainen, Riikka, Liu, Minxia, Kumar, Ashwini, He, Liye, Malani, Disha, Parsons, Alun, Kontro, Mika, Kallioniemi, Olli, Porkka, Kimmo, Heckman, Caroline A.
Published in Leukemia (01.10.2019)
Published in Leukemia (01.10.2019)
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Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones
Ianevski, Aleksandr, Nader, Kristen, Driva, Kyriaki, Senkowski, Wojciech, Bulanova, Daria, Moyano-Galceran, Lidia, Ruokoranta, Tanja, Kuusanmäki, Heikki, Ikonen, Nemo, Sergeev, Philipp, Vähä-Koskela, Markus, Giri, Anil K., Vähärautio, Anna, Kontro, Mika, Porkka, Kimmo, Pitkänen, Esa, Heckman, Caroline A., Wennerberg, Krister, Aittokallio, Tero
Published in Nature communications (03.10.2024)
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Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine
Tambe, Mahesh, Unterberger, Sarah, Kriegbaum, Mette C., Vänttinen, Ida, Olgac, Ezgi June, Vähä-Koskela, Markus, Kontro, Mika, Wennerberg, Krister, Heckman, Caroline A.
Published in Cell death & disease (16.10.2024)
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Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation
Iftakhar-e-Khuda, Imtiaz, Pessia, Alberto, Zheng, Shuyu, Kankainen, Matti, Kontro, Mika, Karikoski, Marika, Laurila, Juha, Gerke, Heidi, Tadayon, Sina, Hollmén, Maija, Tang, Jing, Imhof, Beat A., Salmi, Marko, Jalkanen, Sirpa
Published in Cellular and molecular life sciences : CMLS (01.12.2021)
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Age-specific survival in acute myeloid leukemia in the Nordic countries through a half century
Hemminki, Kari, Zitricky, Frantisek, Försti, Asta, Kontro, Mika, Gjertsen, Bjorn T., Severinsen, Marianne Tang, Juliusson, Gunnar
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P542: A PHASE I/II STUDY TO ASSESS SAFETY, TOLERABILITY AND PRELIMINARY EFFICACY OF BEXMARILIMAB IN COMBINATION WITH STANDARD OF CARE IN PATIENTS WITH MYELOID MALIGNANCIES (BEXMAB)
Kontro, Mika, Siitonen, Timo, Rimpilainen, Johanna, Pyorala, Marja, Pawlitzky, Inka, Aakko, Sofia, Fjaellskog, Marie‐Louise, Hollmén, Maija, Daver, Naval
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms
Kämpjärvi, Kati, Kim, Nam Hee, Keskitalo, Salla, Clark, Alison D., von Nandelstadh, Pernilla, Turunen, Mikko, Heikkinen, Tuomas, Park, Min Ju, Mäkinen, Netta, Kivinummi, Kati, Lintula, Susanna, Hotakainen, Kristina, Nevanlinna, Heli, Hokland, Peter, Böhling, Tom, Bützow, Ralf, Böhm, Jan, Mecklin, Jukka-Pekka, Järvinen, Heikki, Kontro, Mika, Visakorpi, Tapio, Taipale, Jussi, Varjosalo, Markku, Boyer, Thomas G., Vahteristo, Pia
Published in The Prostate (01.01.2016)
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P409: BCL‐2/BCL‐XL INHIBITION INDUCES APOPTOSIS AND CIRCUMVENTS VENETOCLAX RESISTANCE IN TP53‐MUTATED ACUTE MYELOID LEUKEMIA
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Published in HemaSphere (08.08.2023)
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P562: CAPILLARY BLOOD SAMPLING ALLOWS FEASIBLE METHOD FOR VENETOCLAX CONCENTRATION MEASUREMENT IN AN ACADEMIC MULTICENTER CLINICAL TRIAL CONTEXT
Kytölä, Sari, Vänttinen, Ida, Kuusanmäki, Heikki, Ruokoranta, Tanja, Kurkela, Mika, Kiiski, Johanna, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä‐Remes, Maija, Ettala, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, T. Backman, Janne, Niemi, Mikko, Kontro, Mika
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Monosomy 7 and Del(7q) Cause Selective Sensitivity to Inhibitors of Nicotinamide Phosphoribosyltransferase in Acute Myeloid Leukemia
Saad, Joseph, Eldfors, Samuli, Ikonen, Vilma, Gjertsen, Bjørn Tore, Kontro, Mika, Porkka, Kimmo, Heckman, Caroline A.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Trial in Progress: A Phase I/II Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination with Standard of Care in Patients with Hematological Malignancies (BEXMAB)
Pawlitzky, Inka, Siitonen, Timo, Daver, Naval, Jalkanen, Juho, Aako, Sofia, Fjällskog, Marie-Louise, Kontro, Mika
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation
Pemovska, Tea, Johnson, Eric, Kontro, Mika, Repasky, Gretchen A., Chen, Jeffrey, Wells, Peter, Cronin, Ciarán N., McTigue, Michele, Kallioniemi, Olli, Porkka, Kimmo, Murray, Brion W., Wennerberg, Krister
Published in Nature (London) (05.03.2015)
Published in Nature (London) (05.03.2015)
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Encouraging Efficacy Observed in Bexmab Study: A Phase 1/2 Study to Assess Safety and Efficacy of Bexmarilimab in Combination with Standard of Care in Myeloid Malignancies
Kontro, Mika, Stein, Anthony Selwyn, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Hollmén, Maija, Fjaellskog, Marie-Louise, Pawlitzky, Inka, Zeidan, Amer M., Daver, Naval
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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