Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)
Melagraki, Georgia, Ntougkos, Evangelos, Rinotas, Vagelis, Papaneophytou, Christos, Leonis, Georgios, Mavromoustakos, Thomas, Kontopidis, George, Douni, Eleni, Afantitis, Antreas, Kollias, George
Published in PLoS computational biology (01.04.2017)
Published in PLoS computational biology (01.04.2017)
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Structure-Based Discovery of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclastogenesis Inhibitors
Rinotas, Vagelis, Liepouri, Fotini, Ouzouni, Maria-Dimitra, Chalkidi, Niki, Papaneophytou, Christos, Lampropoulou, Mariza, Vidali, Veroniki P, Kontopidis, George, Couladouros, Elias, Eliopoulos, Elias, Papakyriakou, Athanasios, Douni, Eleni
Published in International journal of molecular sciences (01.07.2023)
Published in International journal of molecular sciences (01.07.2023)
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Current Status and Future Prospects of Small-molecule Protein-protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)
Melagraki, Georgia, Leonis, Georgios, Ntougkos, Evangelos, Rinotas, Vagelis, Papaneophytou, Christos, Mavromoustakos, Thomas, Kontopidis, George, Douni, Eleni, Kollias, George, Afantitis, Antreas
Published in Current topics in medicinal chemistry (01.01.2018)
Published in Current topics in medicinal chemistry (01.01.2018)
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Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors
Wang, Shudong, Midgley, Carol A, Scaërou, Frederic, Grabarek, Joanna B, Griffiths, Gary, Jackson, Wayne, Kontopidis, George, McClue, Steven J, McInnes, Campbell, Meades, Christopher, Mezna, Mokdad, Plater, Andy, Stuart, Iain, Thomas, Mark P, Wood, Gavin, Clarke, Rosemary G, Blake, David G, Zheleva, Daniella I, Lane, David P, Jackson, Robert C, Glover, David M, Fischer, Peter M
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design
Kontopidis, George, Wu, Su-Ying, Zheleva, Daniella I., Taylor, Paul, McInnes, Campbell, Lane, David P., Fischer, Peter M., Walkinshaw, Malcolm D., Fersht, Alan
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2005)
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REPLACE: A Strategy for Iterative Design of Cyclin-Binding Groove Inhibitors
Andrews, Martin J.I, Kontopidis, George, McInnes, Campbell, Plater, Andy, Innes, Lorraine, Cowan, Angela, Jewsbury, Philip, Fischer, Peter M
Published in Chembiochem : a European journal of chemical biology (01.12.2006)
Published in Chembiochem : a European journal of chemical biology (01.12.2006)
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Synthesis and biological evaluation of potential small moleculeinhibitors of tumor necrosis factor
Papaneophytou, Christos, Alexiou, Polyxeni, Papakyriakou, Athanasios, Ntougkos, Evangelos, Tsiliouka, Katerina, Maranti, Anna, Liepouri, Fotini, Strongilos, Alexandros, Mettou, Anthi, Couladouros, Elias, Eliopoulos, Elias, Douni, Eleni, Kollias, George, Kontopidis, George
Published in MedChemComm (2015)
Published in MedChemComm (2015)
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Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes
Andrews, MJI, McInnes, C, Kontopidis, G, Innes, L, Cowan, A, Plater, A, Fischer, PM
Published in Organic & biomolecular chemistry (01.01.2004)
Published in Organic & biomolecular chemistry (01.01.2004)
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Classical Anticytokinins Do Not Interact with Cytokinin Receptors but Inhibit Cyclin-dependent Kinases
Spíchal, Lukáŝ, Kryŝtof, Vladimír, Paprskářová, Martina, Lenobel, René, Stýskala, Jakub, Binarová, Pavla, Cenklová, Věra, De Veylder, Lieven, Inzé, Dirk, Kontopidis, George, Fischer, Peter M., Schmuölling, Thomas, Strnad, Miroslav
Published in The Journal of biological chemistry (11.05.2007)
Published in The Journal of biological chemistry (11.05.2007)
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Dual-Polarized 5.75 GHz Optically Transparent Antenna Arrays
Kubwimana, Jean Lambert, Kirsch, Nicholas J., Ziegler, Cyle, Kontopidis, George, Tuner, Brough
Published in IEEE antennas and wireless propagation letters (01.07.2019)
Published in IEEE antennas and wireless propagation letters (01.07.2019)
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Thermodynamic, crystallographic and computational studies of non-mammalian fatty acid binding to bovine β-Lactoglobulin
Rovoli, Magdalini, Thireou, Trias, Choiset, Yvan, Haertlé, Thomas, Sawyer, Lindsay, Eliopoulos, Elias, Kontopidis, George
Published in International journal of biological macromolecules (15.10.2018)
Published in International journal of biological macromolecules (15.10.2018)
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Strong Binding of C‑Glycosylic1,2-Thiodisaccharides to Galectin-3Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds
Lázár, László, Tsagkarakou, Anastasia S., Stravodimos, George, Kontopidis, George, Leffler, Hakon, Nilsson, Ulf J., Somsák, László, Leonidas, Demetres D.
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index
Rinotas, Vagelis, Papakyriakou, Athanasios, Violitzi, Foteini, Papaneophytou, Christos, Ouzouni, Maria-Dimitra, Alexiou, Polyxeni, Strongilos, Alexandros, Couladouros, Elias, Kontopidis, George, Eliopoulos, Elias, Douni, Eleni
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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