Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
Intlekofer, Andrew M, Shih, Alan H, Wang, Bo, Nazir, Abbas, Rustenburg, Ariën S, Albanese, Steven K, Patel, Minal, Famulare, Christopher, Correa, Fabian M, Takemoto, Naofumi, Durani, Vidushi, Liu, Hui, Taylor, Justin, Farnoud, Noushin, Papaemmanuil, Elli, Cross, Justin R, Tallman, Martin S, Arcila, Maria E, Roshal, Mikhail, Petsko, Gregory A, Wu, Bin, Choe, Sung, Konteatis, Zenon D, Biller, Scott A, Chodera, John D, Thompson, Craig B, Levine, Ross L, Stein, Eytan M
Published in Nature (London) (01.07.2018)
Published in Nature (London) (01.07.2018)
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Journal Article
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage
Kalev, Peter, Hyer, Marc L., Gross, Stefan, Konteatis, Zenon, Chen, Chi-Chao, Fletcher, Mark, Lein, Max, Aguado-Fraile, Elia, Frank, Victoria, Barnett, Amelia, Mandley, Everton, Goldford, Joshua, Chen, Yue, Sellers, Katie, Hayes, Sebastian, Lizotte, Kate, Quang, Phong, Tuncay, Yesim, Clasquin, Michelle, Peters, Rachel, Weier, Jaclyn, Simone, Eric, Murtie, Joshua, Liu, Wei, Nagaraja, Raj, Dang, Lenny, Sui, Zhihua, Biller, Scott A., Travins, Jeremy, Marks, Kevin M., Marjon, Katya
Published in Cancer cell (08.02.2021)
Published in Cancer cell (08.02.2021)
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Journal Article
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
Yen, Katharine, Travins, Jeremy, Wang, Fang, David, Muriel D, Artin, Erin, Straley, Kimberly, Padyana, Anil, Gross, Stefan, DeLaBarre, Byron, Tobin, Erica, Chen, Yue, Nagaraja, Raj, Choe, Sung, Jin, Lei, Konteatis, Zenon, Cianchetta, Giovanni, Saunders, Jeffrey O, Salituro, Francesco G, Quivoron, Cyril, Opolon, Paule, Bawa, Olivia, Saada, Véronique, Paci, Angelo, Broutin, Sophie, Bernard, Olivier A, de Botton, Stéphane, Marteyn, Benoît S, Pilichowska, Monika, Xu, YingXia, Fang, Cheng, Jiang, Fan, Wei, Wentao, Jin, Shengfang, Silverman, Lee, Liu, Wei, Yang, Hua, Dang, Lenny, Dorsch, Marion, Penard-Lacronique, Virginie, Biller, Scott A, Su, Shin-San Michael
Published in Cancer discovery (01.05.2017)
Published in Cancer discovery (01.05.2017)
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Journal Article
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
Marjon, Katya, Cameron, Michael J., Quang, Phong, Clasquin, Michelle F., Mandley, Everton, Kunii, Kaiko, McVay, Michael, Choe, Sung, Kernytsky, Andrew, Gross, Stefan, Konteatis, Zenon, Murtie, Joshua, Blake, Michelle L., Travins, Jeremy, Dorsch, Marion, Biller, Scott A., Marks, Kevin M.
Published in Cell reports (Cambridge) (19.04.2016)
Published in Cell reports (Cambridge) (19.04.2016)
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Journal Article
Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
Konteatis, Zenon, Artin, Erin, Nicolay, Brandon, Straley, Kimberly, Padyana, Anil K, Jin, Lei, Chen, Yue, Narayaraswamy, Rohini, Tong, Shuilong, Wang, Feng, Zhou, Ding, Cui, Dawei, Cai, Zhenwei, Luo, Zhiyong, Fang, Cheng, Tang, Huachun, Lv, Xiaobing, Nagaraja, Raj, Yang, Hua, Su, Shin-San M, Sui, Zhihua, Dang, Lenny, Yen, Katharine, Popovici-Muller, Janeta, Codega, Paolo, Campos, Carl, Mellinghoff, Ingo K, Biller, Scott A
Published in ACS medicinal chemistry letters (13.02.2020)
Published in ACS medicinal chemistry letters (13.02.2020)
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Journal Article
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor
Duffy, Joseph L., Kirk, Brian A., Konteatis, Zenon, Campbell, Elizabeth L., Liang, Rui, Brady, Edward J., Candelore, Mari Rios, Ding, Victor D.H., Jiang, Guoqiang, Liu, Frank, Qureshi, Sajjad A., Saperstein, Richard, Szalkowski, Deborah, Tong, Sharon, Tota, Lauri M., Xie, Dan, Yang, Xiaodong, Zafian, Peter, Zheng, Song, Chapman, Kevin T., Zhang, Bei B., Tata, James R.
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Journal Article
Mimicry of Erythropoietin by a Nonpeptide Molecule
Qureshi, Sajjad A., Kim, Ronald M., Konteatis, Zenon, Biazzo, Dawn E., Motamedi, Haideh, Rodrigues, Robert, Boice, Judith A., Calaycay, Jimmy R., Bednarek, Maria A., Griffin, Patrick, Gao, Ying-Duo, Chapman, Kevin, Mark, David F.
Published in Proceedings of the National Academy of Sciences - PNAS (12.10.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (12.10.1999)
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Journal Article
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion
Konteatis, Zenon, Travins, Jeremy, Gross, Stefan, Marjon, Katya, Barnett, Amelia, Mandley, Everton, Nicolay, Brandon, Nagaraja, Raj, Chen, Yue, Sun, Yabo, Liu, Zhixiao, Yu, Jie, Ye, Zhixiong, Jiang, Fan, Wei, Wentao, Fang, Cheng, Gao, Yi, Kalev, Peter, Hyer, Marc L, DeLaBarre, Byron, Jin, Lei, Padyana, Anil K, Dang, Lenny, Murtie, Joshua, Biller, Scott A, Sui, Zhihua, Marks, Kevin M
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML
Choe, Sung, Wang, Hongfang, DiNardo, Courtney D., Stein, Eytan M., de Botton, Stéphane, Roboz, Gail J., Altman, Jessica K., Mims, Alice S., Watts, Justin M., Pollyea, Daniel A., Fathi, Amir T., Tallman, Martin S., Kantarjian, Hagop M., Stone, Richard M., Quek, Lynn, Konteatis, Zenon, Dang, Lenny, Nicolay, Brandon, Nejad, Parham, Liu, Guowen, Zhang, Vickie, Liu, Hua, Goldwasser, Meredith, Liu, Wei, Marks, Kevin, Bowden, Chris, Biller, Scott A., Attar, Eyal C., Wu, Bin
Published in Blood advances (12.05.2020)
Published in Blood advances (12.05.2020)
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Journal Article
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads
Li, Mingzong, Konteatis, Zenon, Nagaraja, Nelamangala, Chen, Yue, Zhou, Shubao, Ma, Guangning, Gross, Stefan, Marjon, Katya, Hyer, Marc L, Mandley, Everton, Lein, Max, Padyana, Anil K, Jin, Lei, Tong, Shuilong, Peters, Rachel, Murtie, Joshua, Travins, Jeremy, Medeiros, Matthew, Liu, Peng, Frank, Victoria, Judd, Evan T, Biller, Scott A, Marks, Kevin M, Sui, Zhihua, Reznik, Samuel K
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Journal Article
Abstract 2714: Targeting MAT2A in CDKN2A/MTAP-deleted cancers
Marjon, Katya, Kalev, Peter, Hyer, Marc, Fletcher, Mark, Zhang, Peili, Aguado-Fraile, Elia, Mandley, Everton, Konteatis, Zenon, Travins, Jeremy, Marks, Kevin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract B115: Mitotic defects induced by MAT2A inhibitors guides translational drug combination strategies with AG-270 and taxanes
Kalev, Peter, Hyer, Marc L, Fletcher, Mark, Zhang, Peili, Aguado-Fraile, Elia, Mandley, Everton, Tuncay, Yesim, Konteatis, Zenon, Travins, Jeremy, Marks, Kevin M, Marjon, Katya
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1-Mutant Relapsed or Refractory Acute Myeloid Leukemia
Choe, Sung, Wang, Hongfang, DiNardo, Courtney D., Stein, Eytan M., De Botton, Stephane, Fathi, Amir T., Tallman, Martin S., Kantarjian, Hagop M., Stone, Richard M., Quek, Lynn, Konteatis, Zenon, Dang, Lenny, Zhang, Vickie, Liu, Hua, Attar, Eyal C., Wu, Bin
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Mat2A의 AZA-헤테로이환 억제제 및 암 치료를 위한 사용 방법
TRAVINS JEREMY M, REZNIK SAMUEL K, KONTEATIS ZENON D, SUI ZHIHUA, LI MINGZONG
Year of Publication 25.04.2022
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Year of Publication 25.04.2022
Patent
THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
ZHOU DING, CAI ZHENWEI, TRAVINS JEREMY M, KONTEATIS ZENON D, POPOVICI MULLER JANETA, ZAHLER ROBERT
Year of Publication 07.03.2022
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Year of Publication 07.03.2022
Patent