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An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism
Lees, Joshua A., Dias, João M., Rajamohan, Francis, Fortin, Jean-Philippe, O’Connor, Rebecca, Kong, Jimmy X., Hughes, Emily A. G., Fisher, Ethan L., Tuttle, Jamison B., Lovett, Gabrielle, Kormos, Bethany L., Unwalla, Rayomand J., Zhang, Lei, Dechert Schmitt, Anne-Marie, Zhou, Dahui, Moran, Michael, Stevens, Kimberly A., Fennell, Kimberly F., Varghese, Alison E., Maxwell, Andrew, Cote, Emmaline E., Zhang, Yuan, Han, Seungil
Published in Nature communications (23.09.2023)
Published in Nature communications (23.09.2023)
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Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss
Garnsey, Michelle R., Smith, Aaron C., Polivkova, Jana, Arons, Autumn L., Bai, Guoyun, Blakemore, Caroline, Boehm, Markus, Buzon, Leanne M., Campion, Sarah N., Cerny, Matthew, Chang, Shiao-Chi, Coffman, Karen, Farley, Kathleen A., Fonseca, Kari R., Ford, Kristen K., Garren, Jeonifer, Kong, Jimmy X., Koos, Martin R. M., Kung, Daniel W., Lian, Yajing, Li, Monica M., Li, Qifang, Martinez-Alsina, Luis A., O’Connor, Rebecca, Ogilvie, Kevin, Omoto, Kiyoyuki, Raymer, Brian, Reese, Matthew R., Ryder, Tim, Samp, Lacey, Stevens, Kimberly A., Widlicka, Daniel W., Yang, Qingyi, Zhu, Kaicheng, Fortin, Jean-Philippe, Sammons, Matthew F.
Published in Journal of medicinal chemistry (09.03.2023)
Published in Journal of medicinal chemistry (09.03.2023)
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Zoniporide: a potent and highly selective inhibitor of human Na +/H + exchanger-1
Marala, Ravi B, Brown, Janice A, Kong, Jimmy X, Tracey, W.Ross, Knight, Delvin R, Wester, Ronald T, Sun, Dexue, Kennedy, Scott P, Hamanaka, Ernest S, Ruggeri, Roger B, Hill, Roger J
Published in European journal of pharmacology (06.09.2002)
Published in European journal of pharmacology (06.09.2002)
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Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity
Liu, Kevin K.-C., Cornelius, Peter, Patterson, Terrell A., Zeng, Yuan, Santucci, Stephanie, Tomlinson, Elizabeth, Gibbons, Colleen, Maurer, Tristan S., Marala, Ravi, Brown, Janice, Kong, Jimmy X., Lee, Eunsun, Werner, Wendy, Wenzel, Zane, Vage, Chandra
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity
Liu, Kevin K.-C., Lefker, Bruce A., Dombroski, Mark A., Chiang, Phoebe, Cornelius, Peter, Patterson, Terrell A., Zeng, Yuan, Santucci, Stephanie, Tomlinson, Elizabeth, Gibbons, Colleen P., Marala, Ravi, Brown, Janice A., Kong, Jimmy X., Lee, Eunsun, Werner, Wendy, Wenzel, Zane, Giragossian, Craig, Chen, Hou, Coffey, Steven B.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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A Novel Sodium-Hydrogen Exchanger Isoform-1 Inhibitor, Zoniporide, Reduces Ischemic Myocardial Injury in Vitro and in Vivo
Knight, Delvin R., Smith, Andrew H., Flynn, David M., MacAndrew, Joseph T., Ellery, Suzanne S., Kong, Jimmy X., Marala, Ravi B., Wester, Ronald T., Guzman-Perez, Angel, Hill, Roger J., Magee, William P., Tracey, W. Ross
Published in The Journal of pharmacology and experimental therapeutics (01.04.2001)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2001)
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An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism
Lees, Joshua A., Dias, João M., Rajamohan, Francis, Fortin, Jean-Philippe, O’Connor, Rebecca, Kong, Jimmy X., Hughes, Emily, Fisher, Ethan L., Tuttle, Jamison B., Lovett, Gabrielle, Kormos, Bethany L., Unwalla, Rayomand J., Zhang, Lei, Schmidt, Anne-Marie Dechert, Zhou, Dahui, Stevens, Kimberly A., Fennell, Kimberly F., Varghese, Alison E., Maxwell, Andrew, Cote, Emmaline E., Zhang, Yuan, Han, Seungil
Published in bioRxiv (01.05.2023)
Published in bioRxiv (01.05.2023)
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