Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML
Duarte, Delfim, Hawkins, Edwin D., Akinduro, Olufolake, Ang, Heather, De Filippo, Katia, Kong, Isabella Y., Haltalli, Myriam, Ruivo, Nicola, Straszkowski, Lenny, Vervoort, Stephin J., McLean, Catriona, Weber, Tom S., Khorshed, Reema, Pirillo, Chiara, Wei, Andrew, Ramasamy, Saravana K., Kusumbe, Anjali P., Duffy, Ken, Adams, Ralf H., Purton, Louise E., Carlin, Leo M., Lo Celso, Cristina
Published in Cell stem cell (04.01.2018)
Published in Cell stem cell (04.01.2018)
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Journal Article
Defining the in vivo characteristics of acute myeloid leukemia cells behavior by intravital imaging
Duarte, Delfim, Amarteifio, Saoirse, Ang, Heather, Kong, Isabella Y, Ruivo, Nicola, Pruessner, Gunnar, Hawkins, Edwin D, Lo Celso, Cristina
Published in Immunology and cell biology (01.02.2019)
Published in Immunology and cell biology (01.02.2019)
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Journal Article
Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation
Kong, Isabella Y., Rimes, Joel S., Light, Amanda, Todorovski, Izabela, Jones, Sarah, Morand, Eric, Knight, Deborah A., Bergman, Ylva E., Hogg, Simon J., Falk, Hendrik, Monahan, Brendon J., Stupple, Paul A., Street, Ian P., Heinzel, Susanne, Bouillet, Philippe, Johnstone, Ricky W., Hodgkin, Philip D., Vervoort, Stephin J., Hawkins, Edwin D.
Published in Cell reports (Cambridge) (20.10.2020)
Published in Cell reports (Cambridge) (20.10.2020)
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Journal Article
RNA kinetics influence the response to transcriptional perturbation in leukaemia cell lines
Todorovski, Izabela, Tsang, Mary-Jane, Feran, Breon, Fan, Zheng, Gadipally, Sreeja, Yoannidis, David, Kong, Isabella Y, Bjelosevic, Stefan, Rivera, Sarahi, Voulgaris, Olivia, Zethoven, Magnus, Hawkins, Edwin D, Simpson, Kaylene J, Arnau, Gisela Mir, Papenfuss, Anthony T, Johnstone, Ricky W, Vervoort, Stephin J
Published in NAR cancer (03.10.2024)
Published in NAR cancer (03.10.2024)
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Journal Article
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
Vervoort, Stephin J., Welsh, Sarah A., Devlin, Jennifer R., Barbieri, Elisa, Knight, Deborah A., Offley, Sarah, Bjelosevic, Stefan, Costacurta, Matteo, Todorovski, Izabela, Kearney, Conor J., Sandow, Jarrod J., Fan, Zheng, Blyth, Benjamin, McLeod, Victoria, Vissers, Joseph H.A., Pavic, Karolina, Martin, Ben P., Gregory, Gareth, Demosthenous, Elena, Zethoven, Magnus, Kong, Isabella Y., Hawkins, Edwin D., Hogg, Simon J., Kelly, Madison J., Newbold, Andrea, Simpson, Kaylene J., Kauko, Otto, Harvey, Kieran F., Ohlmeyer, Michael, Westermarck, Jukka, Gray, Nathanael, Gardini, Alessandro, Johnstone, Ricky W.
Published in Cell (10.06.2021)
Published in Cell (10.06.2021)
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Journal Article
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Simpson, Daniel S., Pang, Jiyi, Weir, Ashley, Kong, Isabella Y., Fritsch, Melanie, Rashidi, Maryam, Cooney, James P., Davidson, Kathryn C., Speir, Mary, Djajawi, Tirta M., Hughes, Sebastian, Mackiewicz, Liana, Dayton, Merle, Anderton, Holly, Doerflinger, Marcel, Deng, Yexuan, Huang, Allan Shuai, Conos, Stephanie A., Tye, Hazel, Chow, Seong H., Rahman, Arfatur, Norton, Raymond S., Naderer, Thomas, Nicholson, Sandra E., Burgio, Gaetan, Man, Si Ming, Groom, Joanna R., Herold, Marco J., Hawkins, Edwin D., Lawlor, Kate E., Strasser, Andreas, Silke, John, Pellegrini, Marc, Kashkar, Hamid, Feltham, Rebecca, Vince, James E.
Published in Immunity (Cambridge, Mass.) (08.03.2022)
Published in Immunity (Cambridge, Mass.) (08.03.2022)
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Journal Article
CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory
Lelliott, Emily J, Kong, Isabella Y, Zethoven, Magnus, Ramsbottom, Kelly M, Martelotto, Luciano G, Meyran, Deborah, Zhu, Joe Jiang, Costacurta, Matteo, Kirby, Laura, Sandow, Jarrod J, Lim, Lydia, Dominguez, Pilar M, Todorovski, Izabela, Haynes, Nicole M, Beavis, Paul A, Neeson, Paul J, Hawkins, Edwin D, McArthur, Grant A, Parish, Ian A, Johnstone, Ricky W, Oliaro, Jane, Sheppard, Karen E, Kearney, Conor J, Vervoort, Stephin J
Published in Cancer discovery (01.10.2021)
Published in Cancer discovery (01.10.2021)
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Journal Article
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development
Goh, Wilford, Sudholz, Harrison, Foroutan, Momeneh, Scheer, Sebastian, Pfefferle, Aline, Delconte, Rebecca B., Meng, Xiangpeng, Shen, Zihan, Hennessey, Robert, Kong, Isabella Y., Schuster, Iona S., Andoniou, Christopher E., Davis, Melissa J., Hediyeh-Zadeh, Soroor, Souza-Fonseca-Guimaraes, Fernando, Parish, Ian A., Beavis, Paul, Thiele, Daniel, Chopin, Michael, Degli-Esposti, Mariapia A., Cursons, Joe, Kallies, Axel, Rautela, Jai, Nutt, Stephen L., Huntington, Nicholas D.
Published in Nature immunology (01.02.2024)
Published in Nature immunology (01.02.2024)
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Journal Article
Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis
Kong, Isabella Y., Trezise, Stephanie, Light, Amanda, Todorovski, Izabela, Arnau, Gisela Mir, Gadipally, Sreeja, Yoannidis, David, Simpson, Kaylene J., Dong, Xueyi, Whitehead, Lachlan, Tempany, Jessica C., Farchione, Anthony J., Sheikh, Amania A., Groom, Joanna R., Rogers, Kelly L., Herold, Marco J., Bryant, Vanessa L., Ritchie, Matthew E., Willis, Simon N., Johnstone, Ricky W., Hodgkin, Philip D., Nutt, Stephen L., Vervoort, Stephin J., Hawkins, Edwin D.
Published in Cell death and differentiation (01.12.2022)
Published in Cell death and differentiation (01.12.2022)
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Journal Article
Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications
Lopes, Marta, Duarte, Tiago L., Teles, Maria J., Mosteo, Laura, Chacim, Sérgio, Aguiar, Eliana, Pereira-Reis, Joana, Oliveira, Mónica, Silva, André M.N., Gonçalves, Nuno, Martins, Gabriela, Kong, Isabella Y., Zethoven, Magnus, Vervoort, Stephin, Martins, Sandra, Quintela, Miguel, Hawkins, Edwin D, Trigo, Fernanda, Guimarães, João T., Mariz, José M., Porto, Graça, Duarte, Delfim
Published in Blood advances (24.08.2021)
Published in Blood advances (24.08.2021)
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Journal Article
An immunohistochemical atlas of necroptotic pathway expression
Chiou, Shene, Al-Ani, Aysha H, Pan, Yi, Patel, Komal M, Kong, Isabella Y, Whitehead, Lachlan W, Light, Amanda, Young, Samuel N, Barrios, Marilou, Sargeant, Callum, Rajasekhar, Pradeep, Zhu, Leah, Hempel, Anne, Lin, Ann, Rickard, James A, Hall, Cathrine, Gangatirkar, Pradnya, Yip, Raymond KH, Cawthorne, Wayne, Jacobsen, Annette V, Horne, Christopher R, Martin, Katherine R, Ioannidis, Lisa J, Hansen, Diana S, Day, Jessica, Wicks, Ian P, Law, Charity, Ritchie, Matthew E, Bowden, Rory, Hildebrand, Joanne M, O’Reilly, Lorraine A, Silke, John, Giulino-Roth, Lisa, Tsui, Ellen, Rogers, Kelly L, Hawkins, Edwin D, Christensen, Britt, Murphy, James M, Samson, André L
Published in EMBO molecular medicine (15.05.2024)
Published in EMBO molecular medicine (15.05.2024)
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Journal Article
Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice
Tye, Hazel, Conos, Stephanie A, Djajawi, Tirta M, Gottschalk, Timothy A, Abdoulkader, Nasteho, Kong, Isabella Y, Kammoun, Helene L, Narayana, Vinod K, Kratina, Tobias, Speir, Mary, Emery, Jack, Simpson, Daniel S, Hall, Cathrine, Vince, Angelina J, Russo, Sophia, Crawley, Rhiannan, Rashidi, Maryam, Hildebrand, Joanne M, Murphy, James M, Whitehead, Lachlan, De Souza, David P, Masters, Seth L, Samson, Andre L, Lalaoui, Najoua, Hawkins, Edwin D, Murphy, Andrew J, Vince, James E, Lawlor, Kate E
Published in Life science alliance (01.01.2025)
Published in Life science alliance (01.01.2025)
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Journal Article
RNA decay defines the therapeutic response to transcriptional perturbation in cancer
Todorovski, Izabela, Breon Feran, Fan, Zheng, Gadipally, Sreeja, Yoannidis, David, Kong, Isabella Y, Hawkins, Edwin D, Simpson, Kaylene J, Gisela Mir Arnau, Papenfuss, Anthony T, Johnstone, Ricky W, Vervoort, Stephin J
Published in bioRxiv (08.04.2022)
Published in bioRxiv (08.04.2022)
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Paper
Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications
Lopes, Marta, Duarte, Tiago L, Teles, Maria J, Mosteo, Laura, Chacim, Sérgio, Aguiar, Eliana, Pereira-Reis, Joana, Oliveira, Mónica, Silva, André M N, Gonçalves, Nuno, Martins, Gabriela, Kong, Isabella Y, Zethoven, Magnus, Vervoort, Stephin, Martins, Sandra, Quintela, Miguel, Hawkins, Edwin D, Trigo, Fernanda, Guimarães, João T, Mariz, José M, Porto, Graça, Duarte, Delfim
Published in bioRxiv (26.10.2020)
Published in bioRxiv (26.10.2020)
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Paper