Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology
Goldberg, Frederick W., Kettle, Jason G., Lamont, Gillian M., Buttar, David, Ting, Attilla K. T., McGuire, Thomas M., Cook, Calum R., Beattie, David, Morentin Gutierrez, Pablo, Kavanagh, Stefan L., Komen, Jasper C., Kawatkar, Aarti, Clark, Roger, Hopcroft, Lorna, Hughes, Gareth, Critchlow, Susan E.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome
Ng, Garrett Z, Menheniott, Trevelyan R, Every, Alison L, Stent, Andrew, Judd, Louise M, Chionh, Yok Teng, Dhar, Poshmaal, Komen, Jasper C, Giraud, Andrew S, Wang, Timothy C, McGuckin, Michael A, Sutton, Philip
Published in Gut (01.07.2016)
Published in Gut (01.07.2016)
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Journal Article
Phytanic acid metabolism in health and disease
Wanders, Ronald J.A., Komen, Jasper, Ferdinandusse, Sacha
Published in Biochimica et biophysica acta (01.09.2011)
Published in Biochimica et biophysica acta (01.09.2011)
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Journal Article
Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy
Ke, Bi-Xia, Pepe, Salvatore, Grubb, David R, Komen, Jasper C, Laskowski, Adrienne, Rodda, Felicity A, Hardman, Belinda M, Pitt, James J, Ryan, Michael T, Lazarou, Michael, Koleff, Jane, Cheung, Michael M. H, Smolich, Joseph J, Thorburn, David R
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2012)
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Journal Article
Ataxia with loss of Purkinje cells in a mouse model for Refsum disease
Ferdinandusse, Sacha, Zomer, Anna W.M, Komen, Jasper C, van den Brink, Christina E, Thanos, Melissa, Hamers, Frank P.T, Wanders, Ronald J.A, van der Saag, Paul T, Poll-The, Bwee Tien, Brites, Pedro
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2008)
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Journal Article
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
Hulme, Heather, Meikle, Lynsey M, Strittmatter, Nicole, van der Hooft, Justin J J, Swales, John, Bragg, Ryan A, Villar, Victor H, Ormsby, Michael J, Barnes, Stephanie, Brown, Sheila L, Dexter, Alex, Kamat, Maya T, Komen, Jasper C, Walker, Daniel, Milling, Simon, Osterweil, Emily K, MacDonald, Andrew S, Schofield, Chris J, Tardito, Saverio, Bunch, Josephine, Douce, Gillian, Edgar, Julia M, Edrada-Ebel, RuAngelie, Goodwin, Richard J A, Burchmore, Richard, Wall, Daniel M
Published in Science advances (01.03.2020)
Published in Science advances (01.03.2020)
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Journal Article
Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene
Leong, Dillon W., Komen, Jasper C., Hewitt, Chelsee A., Arnaud, Estelle, McKenzie, Matthew, Phipson, Belinda, Bahlo, Melanie, Laskowski, Adrienne, Kinkel, Sarah A., Davey, Gayle M., Heath, William R., Voss, Anne K., Zahedi, René P., Pitt, James J., Chrast, Roman, Sickmann, Albert, Ryan, Michael T., Smyth, Gordon K., Thorburn, David R., Scott, Hamish S.
Published in The Journal of biological chemistry (08.06.2012)
Published in The Journal of biological chemistry (08.06.2012)
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Journal Article
Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse
Bird, Matthew J, Wijeyeratne, Xiaonan W, Komen, Jasper C, Laskowski, Adrienne, Ryan, Michael T, Thorburn, David R, Frazier, Ann E
Published in Bioscience reports (21.11.2014)
Published in Bioscience reports (21.11.2014)
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Journal Article
Development of rat pancreatic acinar cell model for the assessment of drug induced injury caused by MCL1 inhibition
Komen, Jasper, Gustafsson, Frida, Basak, Jayati, Leonard, Emilyanne, Harding, Joanna, Mead, Andy, Anderton, Mark
Published in Toxicology letters (20.10.2017)
Published in Toxicology letters (20.10.2017)
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