Inhibition of Both IRAK1 and IRAK4 Is Required for Complete Suppression of NF-Kb Signaling across Multiple Receptor-Mediated Pathways in MDS and AML
Rosenbaum, Jan S, Hoyt, Scott B., Kolt, Amal S., Luedtke, Daniel A, Thomas, Craig J., Starczynowski, Daniel T.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Kme-0584, a Highly Potent IRAK1/IRAK4/panFLT3 Inhibitor, Is a Promising Clinical Candidate for Hypomethylating Agent Plus Venetoclax Resistant AML/MDS Patients
Rosenbaum, Jan S., Kolt, Amal S., Hoyt, Scott B., Hayes, Gregory M., Soldo, Brandi L., Thomas, Craig J., Starczynowski, Daniel T.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML
Bennett, Joshua, Ishikawa, Chiharu, Agarwal, Puneet, Yeung, Jennifer, Sampson, Avery, Uible, Emma, Vick, Eric, Bolanos, Lyndsey C., Hueneman, Kathleen, Wunderlich, Mark, Kolt, Amal, Choi, Kwangmin, Volk, Andrew, Greis, Kenneth D., Rosenbaum, Jan, Hoyt, Scott B., Thomas, Craig J., Starczynowski, Daniel T.
Published in Blood (14.09.2023)
Published in Blood (14.09.2023)
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Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia
Hoyt, Scott B., Finocchio, Chris J., Croll, Elizabeth, Tawa, Gregory J., Li, Huixu, Ma, Li, Li, Kaikai, Liu, Li, Li, Ranran, Zhang, Xiaohu, Wilson, Kelli, Xu, Xin, Shah, Pranav, Williams, Jordan, Fang, Yuhong, Bolanos, Lyndsey C., Gracia-Maldonado, Gabriel, Kolt, Amal, Robinson, Christina, Free, Jessica, Edmondson, Elijah F., Difilippantonio, Simone, Jones, LaQuita M., Culver-Cochran, Ashley E., Rosenbaum, Jan S., Starczynowski, Daniel T., Thomas, Craig J.
Published in ACS medicinal chemistry letters (23.10.2024)
Published in ACS medicinal chemistry letters (23.10.2024)
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