Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial
Mease, Philip J, Rahman, Proton, Gottlieb, Alice B, Kollmeier, Alexa P, Hsia, Elizabeth C, Xu, Xie L, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Zhuang, Yanli, van der Heijde, Désirée, McInnes, Iain B
Published in The Lancet (British edition) (04.04.2020)
Published in The Lancet (British edition) (04.04.2020)
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Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFα inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial
Deodhar, Atul, Helliwell, Philip S, Boehncke, Wolf-Henning, Kollmeier, Alexa P, Hsia, Elizabeth C, Subramanian, Ramanand A, Xu, Xie L, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Zhuang, Yanli, Ritchlin, Christopher T
Published in The Lancet (British edition) (04.04.2020)
Published in The Lancet (British edition) (04.04.2020)
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Long-Term Safety of Guselkumab in Patients with Psoriatic Disease: An Integrated Analysis of Eleven Phase II/III Clinical Studies in Psoriasis and Psoriatic Arthritis
Strober, Bruce, Coates, Laura C., Lebwohl, Mark G., Deodhar, Atul, Leibowitz, Evan, Rowland, Katelyn, Kollmeier, Alexa P., Miller, Megan, Wang, Yanli, Li, Shu, Chakravarty, Soumya D., Chan, Daphne, Shawi, May, Yang, Ya-Wen, Thaҫi, Diamant, Rahman, Proton
Published in Drug safety (01.01.2024)
Published in Drug safety (01.01.2024)
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Long‐Term Efficacy and Safety of Guselkumab, a Monoclonal Antibody Specific to the p19 Subunit of Interleukin‐23, Through Two Years: Results From a Phase III, Randomized, Double‐Blind, Placebo‐Controlled Study Conducted in Biologic‐Naive Patients With Active Psoriatic Arthritis
McInnes, Iain B., Rahman, Proton, Gottlieb, Alice B., Hsia, Elizabeth C., Kollmeier, Alexa P., Xu, Xie L., Jiang, Yusang, Sheng, Shihong, Shawi, May, Chakravarty, Soumya D., Heijde, Désirée, Mease, Philip J.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.03.2022)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.03.2022)
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Guselkumab provides sustained domain-specific and comprehensive efficacy using composite indices in patients with active psoriatic arthritis
Coates, Laura C, Ritchlin, Christopher T, Gossec, Laure, Helliwell, Philip S, Rahman, Proton, Kollmeier, Alexa P, Xu, Xie L, Shawi, May, Karyekar, Chetan S, Contré, Christine, Noël, Wim, Sheng, Shihong, Wang, Yanli, Xu, Stephen, Mease, Philip J
Published in Rheumatology (01.02.2023)
Published in Rheumatology (01.02.2023)
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Journal Article
Guselkumab demonstrated an independent treatment effect in reducing fatigue after adjustment for clinical response-results from two phase 3 clinical trials of 1120 patients with active psoriatic arthritis
Rahman, Proton, Mease, Philip J, Helliwell, Philip S, Deodhar, Atul, Gossec, Laure, Kavanaugh, Arthur, Kollmeier, Alexa P, Hsia, Elizabeth C, Zhou, Bei, Lin, Xiwu, Shawi, May, Karyekar, Chetan S, Han, Chenglong
Published in Arthritis research & therapy (14.07.2021)
Published in Arthritis research & therapy (14.07.2021)
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Journal Article
Safety of Guselkumab With and Without Prior Tumor Necrosis Factor Inhibitor Treatment: Pooled Results Across 4 Studies in Patients With Psoriatic Arthritis
Rahman, Proton, Boehncke, Wolf-Henning, Mease, Philip J, Gottlieb, Alice B, McInnes, Iain B, Shawi, May, Wang, Yanli, Sheng, Shihong, Kollmeier, Alexa P, Theander, Elke, Yu, Jenny, Leibowitz, Evan, Marrache, A Marilise, Coates, Laura C
Published in Journal of rheumatology (01.06.2023)
Published in Journal of rheumatology (01.06.2023)
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Resolution of enthesitis by guselkumab and relationships to disease burden: 1-year results of two phase 3 psoriatic arthritis studies
McGonagle, Dennis, McInnes, Iain B, Deodhar, Atul, Schett, Georg, Shawi, May, Kafka, Shelly, Karyekar, Chetan S, Kollmeier, Alexa P, Hsia, Elizabeth C, Xu, Xie L, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Ritchlin, Christopher T, Rahman, Proton, Mease, Philip J
Published in Rheumatology (Oxford, England) (03.11.2021)
Published in Rheumatology (Oxford, England) (03.11.2021)
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Journal Article
Pooled Safety Results Through 1 Year of 2 Phase III Trials of Guselkumab in Patients With Psoriatic Arthritis
Rahman, Proton, Ritchlin, Christopher T, Helliwell, Philip S, Boehncke, Wolf-Henning, Mease, Philip J, Gottlieb, Alice B, Kafka, Shelly, Kollmeier, Alexa P, Hsia, Elizabeth C, Xu, Xie L, Shawi, May, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Ramachandran, Paraneedharan, Zhuang, Yanli, McInnes, Iain B
Published in Journal of rheumatology (01.12.2021)
Published in Journal of rheumatology (01.12.2021)
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The effect of guselkumab on inhibiting radiographic progression in patients with active psoriatic arthritis: study protocol for APEX, a Phase 3b, multicenter, randomized, double-blind, placebo-controlled trial
Ritchlin, Christopher T, Coates, Laura C, Mease, Philip J, van der Heijde, Désirée, Song, Jiao, Jiang, Yusang, Shawi, May, Kollmeier, Alexa P, Rahman, Proton
Published in Current controlled trials in cardiovascular medicine (10.01.2023)
Published in Current controlled trials in cardiovascular medicine (10.01.2023)
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Journal Article
Modulation of Interleukin‐23 Signaling With Guselkumab in Biologic‐Naive Patients Versus Tumor Necrosis Factor Inhibitor–Inadequate Responders With Active Psoriatic Arthritis
Siebert, Stefan, Coates, Laura C., Schett, Georg, Raychaudhuri, Siba P., Chen, Warner, Gao, Sheng, Seridi, Loqmane, Chakravarty, Soumya D., Shawi, May, Lavie, Frederic, Sharaf, Mohamed, Zimmermann, Miriam, Kollmeier, Alexa P., Xu, Xie L., Rahman, Proton, Mease, Philip J., Deodhar, Atul
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2024)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2024)
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Efficacy of guselkumab on axial involvement in patients with active psoriatic arthritis and sacroiliitis: a post-hoc analysis of the phase 3 DISCOVER-1 and DISCOVER-2 studies
Mease, Philip J, Helliwell, Philip S, Gladman, Dafna D, Poddubnyy, Denis, Baraliakos, Xenofon, Chakravarty, Soumya D, Kollmeier, Alexa P, Hsia, Elizabeth C, Xu, Xie L, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Sweet, Kristen, Shawi, May, Karyekar, Chetan S, Deodhar, Atul, van der Heijde, Désirée
Published in The Lancet. Rheumatology (01.10.2021)
Published in The Lancet. Rheumatology (01.10.2021)
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Guselkumab, an inhibitor of the IL-23p19 subunit, provides sustained improvement in signs and symptoms of active psoriatic arthritis: 1 year results of a phase III randomised study of patients who were biologic-naïve or TNFα inhibitor-experienced
Ritchlin, Christopher T, Helliwell, Philip S, Boehncke, Wolf-Henning, Soriano, Enrique R, Hsia, Elizabeth C, Kollmeier, Alexa P, Chakravarty, Soumya D, Zazzetti, Federico, Subramanian, Ramanand A, Xu, Xie L, Zuraw, Qing C, Sheng, Shihong, Jiang, Yusang, Agarwal, Prasheen, Zhou, Bei, Zhuang, Yanli, Shawi, May, Karyekar, Chetan S, Deodhar, Atul
Published in Rheumatic & musculoskeletal diseases open (01.02.2021)
Published in Rheumatic & musculoskeletal diseases open (01.02.2021)
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A phase 2a study of toreforant, a histamine H4 receptor antagonist, in eosinophilic asthma
Kollmeier, Alexa P., Barnathan, Elliot S., O'Brien, Christopher, Chen, Bin, Xia, Yichuan (Karen), Zhou, Bei, Loza, Matthew J., Silkoff, Philip E., Ge, Michelle, Thurmond, Robin L.
Published in Annals of allergy, asthma, & immunology (01.11.2018)
Published in Annals of allergy, asthma, & immunology (01.11.2018)
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Efficacy of Guselkumab on Axial-Related Symptoms Through up to 2 Years in Adults with Active Psoriatic Arthritis in the Phase 3, Randomized, Placebo-Controlled DISCOVER-2 Study
Mease, Philip J., Gladman, Dafna D., Poddubnyy, Denis, Chakravarty, Soumya D., Shawi, May, Kollmeier, Alexa P., Xu, Xie L., Xu, Stephen, Deodhar, Atul, Baraliakos, Xenofon
Published in Rheumatology and therapy. (01.12.2023)
Published in Rheumatology and therapy. (01.12.2023)
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Journal Article
Sustained and improved guselkumab response in patients with active psoriatic arthritis regardless of baseline demographic and disease characteristics: pooled results through week 52 of two phase III, randomised, placebo-controlled studies
Ritchlin, Christopher T, Mease, Philip J, Boehncke, Wolf-Henning, Tesser, John, Schiopu, Elena, Chakravarty, Soumya D, Kollmeier, Alexa P, Xu, Xie L, Shawi, May, Jiang, Yusang, Sheng, Shihong, Wang, Yanli, Xu, Stephen, Merola, Joseph F, McInnes, Iain B, Deodhar, Atul
Published in Rheumatic & musculoskeletal diseases open (01.03.2022)
Published in Rheumatic & musculoskeletal diseases open (01.03.2022)
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Journal Article
Guselkumab, a Selective Interleukin‐23 p19 Subunit Inhibitor, Resolves Dactylitis in Patients With Active Psoriatic Arthritis: Pooled Results Through Week 52 From Two Phase 3 Studies
McGonagle, Dennis, McInnes, Iain B., Deodhar, Atul, Schett, Georg, Shawi, May, Chakravarty, Soumya D., Kollmeier, Alexa P., Xu, Xie L., Sheng, Shihong, Xu, Stephen, Ritchlin, Christopher T., Rahman, Proton, Mease, Phillip J.
Published in ACR open rheumatology (01.04.2023)
Published in ACR open rheumatology (01.04.2023)
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Journal Article
Association between enthesitis/dactylitis resolution and patient-reported outcomes in guselkumab-treated patients with psoriatic arthritis
Rahman, Proton, McInnes, Iain B., Deodhar, Atul, Schett, Georg, Mease, Phillip J., Shawi, May, Cua, Daniel J., Sherlock, Jonathan P., Kollmeier, Alexa P., Xu, Xie L., Sheng, Shihong, Ritchlin, Christopher T., McGonagle, Dennis
Published in Clinical rheumatology (01.05.2024)
Published in Clinical rheumatology (01.05.2024)
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Journal Article
Efficacy and Safety of Guselkumab, an Interleukin‐23p19–Specific Monoclonal Antibody, Through One Year in Biologic‐Naive Patients With Psoriatic Arthritis
McInnes, Iain B., Rahman, Proton, Gottlieb, Alice B., Hsia, Elizabeth C., Kollmeier, Alexa P., Chakravarty, Soumya D., Xu, Xie L., Subramanian, Ramanand A., Agarwal, Prasheen, Sheng, Shihong, Jiang, Yusang, Zhou, Bei, Zhuang, Yanli, Heijde, Désirée, Mease, Philip J.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2021)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2021)
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The Effect of Guselkumab on General Health State in Biologic-Naïve Patients with Active Psoriatic Arthritis Through Week 52 of the Phase 3, Randomized, Placebo-Controlled DISCOVER-2 Trial
Curtis, Jeffrey R., McInnes, Iain B., Rahman, Proton, Gladman, Dafna D., Yang, Feifei, Peterson, Steven, Agarwal, Prasheen, Kollmeier, Alexa P., Hsia, Elizabeth C., Han, Chenglong, Shiff, Natalie J., Shawi, May, Tillett, William, Mease, Philip J.
Published in Advances in therapy (01.10.2022)
Published in Advances in therapy (01.10.2022)
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