COVID-19 vaccine platforms: Delivering on a promise?
Verdecia, Mark, Kokai-Kun, John F., Kibbey, Maura, Acharya, Sarita, Venema, Jaap, Atouf, Fouad
Published in Human vaccines & immunotherapeutics (02.09.2021)
Published in Human vaccines & immunotherapeutics (02.09.2021)
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Catalase (KatA) and Alkyl Hydroperoxide Reductase (AhpC) Have Compensatory Roles in Peroxide Stress Resistance and Are Required for Survival, Persistence, and Nasal Colonization in Staphylococcus aureus
COSGROVE, Kate, COUTTS, Graham, JONSSON, Ing-Marie, TARKOWSKI, Andrej, KOKAI-KUN, John F, MOND, James J, FOSTER, Simon J
Published in Journal of Bacteriology (01.02.2007)
Published in Journal of Bacteriology (01.02.2007)
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Identification of In Vivo–Expressed Antigens of Staphylococcus aureus and Their Use in Vaccinations for Protection against Nasal Carriage
Clarke, Simon R., Brummell, Kirsten J., Horsburgh, Malcolm J., McDowell, Philip W., Mohamad, Sharifah A. Syed, Stapleton, Melanie R., Acevedo, Jorge, Read, Robert C., Day, Nicholas P. J., Peacock, Sharon J., Mond, James J., Kokai-Kun, John F., Foster, Simon J.
Published in The Journal of infectious diseases (15.04.2006)
Published in The Journal of infectious diseases (15.04.2006)
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Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections
Peschel, Andreas, Weidenmaier, Christopher, Kokai-Kun, John F, Kristian, Sascha A, Chanturiya, Tanya, Kalbacher, Hubert, Gross, Matthias, Nicholson, Graeme, Neumeister, Birgid, Mond, James J
Published in Nature medicine (01.03.2004)
Published in Nature medicine (01.03.2004)
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Characterization of IsaA and SceD, Two Putative Lytic Transglycosylases of Staphylococcus aureus
Stapleton, Melanie R, Horsburgh, Malcolm J, Hayhurst, Emma J, Wright, Lynda, Jonsson, Ing-Marie, Tarkowski, Andrej, Kokai-Kun, John F, Mond, James J, Foster, Simon J
Published in Journal of Bacteriology (01.10.2007)
Published in Journal of Bacteriology (01.10.2007)
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Use of ribaxamase (SYN-004), a β-lactamase, to prevent Clostridium difficile infection in β-lactam-treated patients: a double-blind, phase 2b, randomised placebo-controlled trial
Kokai-Kun, John F, Roberts, Tracey, Coughlin, Olivia, Le, Chenxiong, Whalen, Heidi, Stevenson, Ralph, Wacher, Vincent J, Sliman, Joseph
Published in The Lancet infectious diseases (01.05.2019)
Published in The Lancet infectious diseases (01.05.2019)
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Phase 1/2 Double-Blind, Placebo-Controlled, Dose Escalation, Safety, and Pharmacokinetic Study of Pagibaximab (BSYX-A110), an Antistaphylococcal Monoclonal Antibody for the Prevention of Staphylococcal Bloodstream Infections, in Very-Low-Birth-Weight Neonates
Weisman, Leonard E, Thackray, Helen M, Garcia-Prats, Joseph A, Nesin, Mirjana, Schneider, Joseph H, Fretz, Jennifer, Kokai-Kun, John F, Mond, James J, Kramer, William G, Fischer, Gerald W
Published in Antimicrobial Agents and Chemotherapy (01.07.2009)
Published in Antimicrobial Agents and Chemotherapy (01.07.2009)
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Differential roles of sortase-anchored surface proteins and wall teichoic acid in Staphylococcus aureus nasal colonization
Weidenmaier, Christopher, Kokai-Kun, John F, Kulauzovic, Emir, Kohler, Thomas, Thumm, Günther, Stoll, Hartmut, Götz, Friedrich, Peschel, Andreas
Published in International journal of medical microbiology (01.07.2008)
Published in International journal of medical microbiology (01.07.2008)
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The Oral β-Lactamase SYN-004 (Ribaxamase) Degrades Ceftriaxone Excreted into the Intestine in Phase 2a Clinical Studies
Kokai-Kun, John F, Roberts, Tracey, Coughlin, Olivia, Sicard, Eric, Rufiange, Marianne, Fedorak, Richard, Carter, Christian, Adams, Marijke H, Longstreth, James, Whalen, Heidi, Sliman, Joseph
Published in Antimicrobial agents and chemotherapy (01.03.2017)
Published in Antimicrobial agents and chemotherapy (01.03.2017)
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Activation of Shiga toxin type 2d (Stx2d) by elastase involves cleavage of the C‐terminal two amino acids of the A2 peptide in the context of the appropriate B pentamer
Melton‐Celsa, Angela R., Kokai‐Kun, John F., O’Brien, Alison D.
Published in Molecular microbiology (01.01.2002)
Published in Molecular microbiology (01.01.2002)
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The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin
Clarke, Simon R, Mohamed, Ramlan, Bian, Li, Routh, Alexander F, Kokai-Kun, John F, Mond, James J, Tarkowski, Andrej, Foster, Simon J
Published in Cell host & microbe (17.05.2007)
Published in Cell host & microbe (17.05.2007)
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Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection
Kaleko, Michael, Bristol, J. Andrew, Hubert, Steven, Parsley, Todd, Widmer, Giovanni, Tzipori, Saul, Subramanian, Poorani, Hasan, Nur, Koski, Perrti, Kokai-Kun, John, Sliman, Joseph, Jones, Annie, Connelly, Sheila
Published in Anaerobe (01.10.2016)
Published in Anaerobe (01.10.2016)
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SYN-004 (Ribaxamase), an Oral β-Lactamase, Prevented Clostridium Difficile Infection and Protected Patients from Colonization by Antimicrobial Resistant Pathogens by Preserving Gut Microbiome Diversity in a Phase 2B Clinical Trial
Kokai-Kun, John F, Roberts, Tracey, Coughlin, Olivia, Whalen, Heidi, Le, Chenxiong C, Gottlieb, Klaus T, Sliman, Joseph
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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A randomized study of a monoclonal antibody (pagibaximab) to prevent staphylococcal sepsis
Weisman, Leonard E, Thackray, Helen M, Steinhorn, Robin H, Walsh, William F, Lassiter, Herbert A, Dhanireddy, Ramasubbareddy, Brozanski, Beverly S, Palmer, Kristine G H, Trautman, Michael S, Escobedo, Marilyn, Meissner, H Cody, Sasidharan, Pontthenkandath, Fretz, Jennifer, Kokai-Kun, John F, Kramer, William G, Fischer, Gerald W, Mond, James J
Published in Pediatrics (Evanston) (01.08.2011)
Published in Pediatrics (Evanston) (01.08.2011)
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