Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Atabaki-Pasdar, Naeimeh, Ohlsson, Mattias, Viñuela, Ana, Frau, Francesca, Pomares-Millan, Hugo, Haid, Mark, Jones, Angus G, Thomas, E Louise, Koivula, Robert W, Kurbasic, Azra, Mutie, Pascal M, Fitipaldi, Hugo, Fernandez, Juan, Dawed, Adem Y, Giordano, Giuseppe N, Forgie, Ian M, McDonald, Timothy J, Rutters, Femke, Cederberg, Henna, Chabanova, Elizaveta, Dale, Matilda, Masi, Federico De, Thomas, Cecilia Engel, Allin, Kristine H, Hansen, Tue H, Heggie, Alison, Hong, Mun-Gwan, Elders, Petra J M, Kennedy, Gwen, Kokkola, Tarja, Pedersen, Helle Krogh, Mahajan, Anubha, McEvoy, Donna, Pattou, Francois, Raverdy, Violeta, Häussler, Ragna S, Sharma, Sapna, Thomsen, Henrik S, Vangipurapu, Jagadish, Vestergaard, Henrik, 't Hart, Leen M, Adamski, Jerzy, Musholt, Petra B, Brage, Soren, Brunak, Søren, Dermitzakis, Emmanouil, Frost, Gary, Hansen, Torben, Laakso, Markku, Pedersen, Oluf, Ridderstråle, Martin, Ruetten, Hartmut, Hattersley, Andrew T, Walker, Mark, Beulens, Joline W J, Mari, Andrea, Schwenk, Jochen M, Gupta, Ramneek, McCarthy, Mark I, Pearson, Ewan R, Bell, Jimmy D, Pavo, Imre, Franks, Paul W
Published in PLoS medicine (19.06.2020)
Published in PLoS medicine (19.06.2020)
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Journal Article
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
Ahmad, Shafqat, Rukh, Gull, Varga, Tibor V, Ali, Ashfaq, Kurbasic, Azra, Shungin, Dmitry, Ericson, Ulrika, Koivula, Robert W, Chu, Audrey Y, Rose, Lynda M, Ganna, Andrea, Qi, Qibin, Stančáková, Alena, Sandholt, Camilla H, Elks, Cathy E, Curhan, Gary, Jensen, Majken K, Tamimi, Rulla M, Allin, Kristine H, Jørgensen, Torben, Brage, Soren, Langenberg, Claudia, Aadahl, Mette, Grarup, Niels, Linneberg, Allan, Paré, Guillaume, Magnusson, Patrik K E, Pedersen, Nancy L, Boehnke, Michael, Hamsten, Anders, Mohlke, Karen L, Pasquale, Louis T, Pedersen, Oluf, Scott, Robert A, Ridker, Paul M, Ingelsson, Erik, Laakso, Markku, Hansen, Torben, Qi, Lu, Wareham, Nicholas J, Chasman, Daniel I, Hallmans, Göran, Hu, Frank B, Renström, Frida, Orho-Melander, Marju, Franks, Paul W
Published in PLoS genetics (2013)
Published in PLoS genetics (2013)
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Journal Article
Bicycling to Work and Primordial Prevention of Cardiovascular Risk: A Cohort Study Among Swedish Men and Women
Grøntved, Anders, Koivula, Robert W., Johansson, Ingegerd, Wennberg, Patrik, Østergaard, Lars, Hallmans, Göran, Renström, Frida, Franks, Paul W.
Published in Journal of the American Heart Association (01.11.2016)
Published in Journal of the American Heart Association (01.11.2016)
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Journal Article
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study
Obura, Morgan, Beulens, Joline W J, Slieker, Roderick, Koopman, Anitra D M, Hoekstra, Trynke, Nijpels, Giel, Elders, Petra, Koivula, Robert W, Kurbasic, Azra, Laakso, Markku, Hansen, Tue H, Ridderstråle, Martin, Hansen, Torben, Pavo, Imre, Forgie, Ian, Jablonka, Bernd, Ruetten, Hartmut, Mari, Andrea, McCarthy, Mark I, Walker, Mark, Heggie, Alison, McDonald, Timothy J, Perry, Mandy H, De Masi, Federico, Brunak, Søren, Mahajan, Anubha, Giordano, Giuseppe N, Kokkola, Tarja, Dermitzakis, Emmanouil, Viñuela, Ana, Pedersen, Oluf, Schwenk, Jochen M, Adamski, Jurek, Teare, Harriet J A, Pearson, Ewan R, Franks, Paul W, 't Hart, Leen M, Rutters, Femke
Published in PloS one (30.11.2020)
Published in PloS one (30.11.2020)
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Journal Article
Genetic determinants of long-term changes in blood lipid concentrations: 10-year follow-up of the GLACIER study
Varga, Tibor V, Sonestedt, Emily, Shungin, Dmitry, Koivula, Robert W, Hallmans, Göran, Escher, Stefan A, Barroso, Inês, Nilsson, Peter, Melander, Olle, Orho-Melander, Marju, Renström, Frida, Franks, Paul W
Published in PLoS genetics (01.06.2014)
Published in PLoS genetics (01.06.2014)
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Journal Article
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
Ahmad, Abrar, Aiken, Catherine, Clark, Amy L., Colclough, Kevin, Duan, Daisy, Felton, Jamie L., Francis, Ellen C., Gillard, Pieter, Gaillard, Romy, Haider, Eram, Ikle, Jennifer M., Jacobsen, Laura M., Kahkoska, Anna R., Kreienkamp, Raymond J., Männistö, Jonna M. E., Mclennan, Niamh-Maire, Morieri, Mario Luca, Most, Jasper, Naylor, Rochelle N., Ozkan, Bige, Prystupa, Katsiaryna, Rooney, Mary R., Schön, Martin, Semnani-Azad, Zhila, Thuesen, Anne Cathrine B., Tosur, Mustafa, Wang, Caroline C., Wong, Jessie J., Young, Katherine, Amouyal, Chloé, Clemmensen, Christoffer, Dabelea, Dana, Dawed, Adem Y., Dudenhöffer-Pfeifer, Monika, Fernández-Balsells, María Mercè, Gitelman, Stephen E., Goodarzi, Mark O., Habibi, Nahal, Harris-Kawano, Arianna, Hoag, Benjamin, Johnson, Randi K., Koivula, Robert W., Leong, Aaron, Libman, Ingrid M., Liu, Kai, Long, S. Alice, Motala, Ayesha A., Onengut-Gumuscu, Suna, Pathirana, Maleesa, Jain, Rashmi, Ray, Debashree, Sarkar, Sudipa, Scholtens, Denise M., Speake, Cate, Stanislawski, Maggie A., Steenackers, Nele, Steck, Andrea K., Stefan, Norbert, Tye, Sok Cin, Urazbayeva, Marzhan, White, Sara L., Yu, Gechang, Zhang, Yingchai, Beltrand, Jacques, Aukrust, Ingvild, Flanagan, Sarah E., Maloney, Kristin A., McGovern, Andrew, Zhang, Cuilin, Zhu, Yeyi, Auh, Sungyoung, Fawcett, Andrea J., Gruber, Chandra, Sherifali, Diana, Nolan, John J., Billings, Liana K., Boyle, Kristen, Costacou, Tina, Dennis, John M., Florez, Jose C., Gloyn, Anna L., Gottlieb, Peter A., Greeley, Siri Atma W., Hattersley, Andrew T., Josefson, Jami L., Loos, Ruth J. F., Ma, Ronald C. W., Mathieu, Chantal, Misra, Shivani, Murphy, Rinki, Owen, Katharine R., Ozanne, Susan E., Pearson, Ewan R., Pollin, Toni I., Pratley, Richard E., Semple, Robert K., Sweeting, Arianne, Vesco, Kimberly K., Wagner, Robert, Rich, Stephen S.
Published in Nature medicine (01.10.2023)
Published in Nature medicine (01.10.2023)
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Journal Article
Polygenic risk in Type III hyperlipidaemia and risk of cardiovascular disease: An epidemiological study in UK Biobank and Oxford Biobank
Pieri, Kyriaki, Trichia, Eirini, Neville, Matt J., Taylor, Hannah, Bennett, Derrick, Karpe, Fredrik, Koivula, Robert W.
Published in International journal of cardiology (15.02.2023)
Published in International journal of cardiology (15.02.2023)
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Journal Article
Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study
de Klerk, Juliette A., Beulens, Joline W. J., Mei, Hailiang, Bijkerk, Roel, van Zonneveld, Anton Jan, Koivula, Robert W., Elders, Petra J. M., ’t Hart, Leen M., Slieker, Roderick C.
Published in Diabetologia (01.06.2023)
Published in Diabetologia (01.06.2023)
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Journal Article
Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study
Sharma, Sapna, Dong, Qiuling, Haid, Mark, Adam, Jonathan, Bizzotto, Roberto, Fernandez-Tajes, Juan J, Jones, Angus G, Tura, Andrea, Artati, Anna, Prehn, Cornelia, Kastenmüller, Gabi, Koivula, Robert W, Franks, Paul W, Walker, Mark, Forgie, Ian M, Giordano, Giuseppe, Pavo, Imre, Ruetten, Hartmut, Dermitzakis, Manolis, McCarthy, Mark I, Pedersen, Oluf, Schwenk, Jochen M, Tsirigos, Konstantinos D, De Masi, Federico, Brunak, Soren, Viñuela, Ana, Mari, Andrea, McDonald, Timothy J, Kokkola, Tarja, Adamski, Jerzy, Pearson, Ewan R, Grallert, Harald
Published in Diabetologia (30.09.2024)
Published in Diabetologia (30.09.2024)
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Journal Article
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study
Tura, Andrea, Grespan, Eleonora, Göbl, Christian S., Koivula, Robert W., Franks, Paul W., Pearson, Ewan R., Walker, Mark, Forgie, Ian M., Giordano, Giuseppe N., Pavo, Imre, Ruetten, Hartmut, Dermitzakis, Emmanouil T., McCarthy, Mark I., Pedersen, Oluf, Schwenk, Jochen M., Adamski, Jerzy, De Masi, Federico, Tsirigos, Konstantinos D., Brunak, Søren, Viñuela, Ana, Mahajan, Anubha, McDonald, Timothy J., Kokkola, Tarja, Vangipurapu, Jagadish, Cederberg, Henna, Laakso, Markku, Rutters, Femke, Elders, Petra J.M., Koopman, Anitra D.M., Beulens, Joline W., Ridderstråle, Martin, Hansen, Tue H., Allin, Kristine H., Hansen, Torben, Vestergaard, Henrik, Mari, Andrea, 't Hart, Leen M., Abdalla, Moustafa, Adam, Jonathan, Adamski, Jerzy, Adragni, Kofi, Allesøe, Rosa L., Allin, Kristine H., Arumugam, Manimozhiyan, Atabaki Pasdar, Naeimeh, Baltauss, Tania, Banasik, Karina, Baum, Patrick, Bell, Jimmy D., Bergstrom, Margit, Beulens, Joline W., Bianzano, Susaana, Bizzotto, Roberto, Bonneford, Amelie, Brorsson, Caroline Anna, Brown, Andrew A., Brunak, Søren, Cabrelli, Louise, Caiazzo, Robert, Canouil, Mickael, Cederberg, Henna, Dale, Matilda, Davtian, David, Dawed, Adem Y., De Masi, Federico, de Preville, Nathalie, Dekkers, Koen F., Dermitzakis, Emmanouil T., Deshmukh, Harshal A., Dings, Christiane, Donnelly, Louise, Dutta, Avirup, Ehrhardt, Beate, Elders, Petra J. M., Engelbrechtsen, Line, Eriksen, Rebeca, Fan, Yong, Fernandez, Juan, Ferrer, Jorge, Fitipaldi, Hugo, Forgie, Ian M., Forman, Annemette, Franks, Paul W., Frau, Francesca, Fritsche, Andreas, Froguel, Philippe, Frost, Gary, Gassenhuber, Johann, Giordano, Giuseppe N., Giorgino, Toni, Gough, Stephen, Graefe-Mody, Ulrike, Grallert, Harald, Grempler, Rolf, Groeneveld, Lenka, Groop, Leif, Gudmundsdóttir, Valborg, Gupta, Ramneek, Haid, Mark, Hansen, Torben
Published in Diabetes (New York, N.Y.) (01.09.2021)
Published in Diabetes (New York, N.Y.) (01.09.2021)
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Journal Article
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
Brown, Andrew A., Fernandez-Tajes, Juan J., Hong, Mun-gwan, Brorsson, Caroline A., Koivula, Robert W., Davtian, David, Dupuis, Théo, Sartori, Ambra, Michalettou, Theodora-Dafni, Forgie, Ian M., Adam, Jonathan, Allin, Kristine H., Caiazzo, Robert, Cederberg, Henna, De Masi, Federico, Elders, Petra J. M., Giordano, Giuseppe N., Haid, Mark, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew T., Heggie, Alison J., Howald, Cédric, Jones, Angus G., Kokkola, Tarja, Laakso, Markku, Mahajan, Anubha, Mari, Andrea, McDonald, Timothy J., McEvoy, Donna, Mourby, Miranda, Musholt, Petra B., Nilsson, Birgitte, Pattou, Francois, Penet, Deborah, Raverdy, Violeta, Ridderstråle, Martin, Romano, Luciana, Rutters, Femke, Sharma, Sapna, Teare, Harriet, ‘t Hart, Leen, Tsirigos, Konstantinos D., Vangipurapu, Jagadish, Vestergaard, Henrik, Brunak, Søren, Franks, Paul W., Frost, Gary, Grallert, Harald, Jablonka, Bernd, McCarthy, Mark I., Pavo, Imre, Pedersen, Oluf, Ruetten, Hartmut, Walker, Mark, Adamski, Jerzy, Schwenk, Jochen M., Pearson, Ewan R., Dermitzakis, Emmanouil T., Viñuela, Ana
Published in Nature communications (21.08.2023)
Published in Nature communications (21.08.2023)
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Journal Article
The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study
Eriksen, Rebeca, White, Margaret C, Dawed, Adem Y, Perez, Isabel Garcia, Posma, Joram M, Haid, Mark, Sharma, Sapna, Prehn, Cornelia, Thomas, E Louise, Koivula, Robert W, Bizzotto, Roberto, Mari, Andrea, Giordano, Giuseppe N, Pavo, Imre, Schwenk, Jochen M, De Masi, Federico, Tsirigos, Konstantinos D, Brunak, Søren, Viñuela, Ana, Mahajan, Anubha, McDonald, Timothy J, Kokkola, Tarja, Rutters, Femke, Beulens, Joline, Muilwijk, Mirthe, Blom, Marieke, Elders, Petra, Hansen, Tue H, Fernandez-Tajes, Juan, Jones, Angus, Jennison, Chris, Walker, Mark, McCarthy, Mark I, Pedersen, Oluf, Ruetten, Hartmut, Forgie, Ian, Holst, Jens J, Thomsen, Henrik S, Ridderstråle, Martin, Bell, Jimmy D, Adamski, Jerzy, Franks, Paul W, Hansen, Torben, Holmes, Elaine, Frost, Gary, Pearson, Ewan R
Published in The journal of clinical endocrinology and metabolism (13.08.2024)
Published in The journal of clinical endocrinology and metabolism (13.08.2024)
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Journal Article
Gene x physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
Ahmad, Shafqat, Rukh, Gull, Varga, Tibor V, Ali, Ashfaq, Kurbasic, Azra, Shungin, Dmitry, Ericson, Ulrika, Koivula, Robert W, Chu, Audrey Y, Rose, Lynda M, Ganna, Andrea, Qi, Qibin, Stancakova, Alena, Sandholt, Camilla H, Elks, Cathy E, Curhan, Gary, Jensen, Majken K, Tamimi, Rulla M, Allin, Kristine H, Jorgensen, Torben, Brage, Soren, Langenberg, Claudia, Aadahl, Mette, Grarup, Niels, Linneberg, Allan, Pare, Guillaume, Magnusson, Patrik KE, Pedersen, Nancy L, Boehnke, Michael, Hamsten, Anders, Mohlke, Karen L, Pasquale, Louis T, Pedersen, Oluf, Scott, Robert A, Ridker, Paul M, Ingelsson, Erik, Laakso, Markku, Hansen, Torben, Qi, Lu, Wareham, Nicholas J, Chasman, Daniel I, Hallmans, Göran, Hu, Frank B, Renström, Frida, Orho-Melander, Marju, Franks, Paul W.
Published in PLoS genetics (01.07.2013)
Published in PLoS genetics (01.07.2013)
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Journal Article
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Bizzotto, Roberto, Jennison, Christopher, Jones, Angus G, Kurbasic, Azra, Tura, Andrea, Kennedy, Gwen, Bell, Jimmy D, Thomas, E Louise, Frost, Gary, Eriksen, Rebeca, Koivula, Robert W, Brage, Soren, Kaye, Jane, Hattersley, Andrew T, Heggie, Alison, McEvoy, Donna, 't Hart, Leen M, Beulens, Joline W, Elders, Petra, Musholt, Petra B, Ridderstråle, Martin, Hansen, Tue H, Allin, Kristine H, Hansen, Torben, Vestergaard, Henrik, Lundgaard, Agnete T, Thomsen, Henrik S, De Masi, Federico, Tsirigos, Konstantinos D, Brunak, Søren, Viñuela, Ana, Mahajan, Anubha, McDonald, Timothy J, Kokkola, Tarja, Forgie, Ian M, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Dermitzakis, Emmanouil, McCarthy, Mark I, Pedersen, Oluf, Schwenk, Jochen M, Adamski, Jerzy, Franks, Paul W, Walker, Mark, Pearson, Ewan R, Mari, Andrea
Published in Diabetes care (01.02.2021)
Published in Diabetes care (01.02.2021)
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Journal Article
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity
Deshmukh, Harshal A, Madsen, Anne Lundager, Viñuela, Ana, Have, Christian Theil, Grarup, Niels, Tura, Andrea, Mahajan, Anubha, Heggie, Alison J, Koivula, Robert W, De Masi, Federico, Tsirigos, Konstantinos K, Linneberg, Allan, Drivsholm, Thomas, Pedersen, Oluf, Sørensen, Thorkild I A, Astrup, Arne, Gjesing, Anette A P, Pavo, Imre, Wood, Andrew R, Ruetten, Hartmut, Jones, Angus G, Koopman, Anitra D M, Cederberg, Henna, Rutters, Femke, Ridderstrale, Martin, Laakso, Markku, McCarthy, Mark I, Frayling, Tim M, Ferrannini, Ele, Franks, Paul W, Pearson, Ewan R, Mari, Andrea, Hansen, Torben, Walker, Mark
Published in The journal of clinical endocrinology and metabolism (01.01.2021)
Published in The journal of clinical endocrinology and metabolism (01.01.2021)
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Journal Article
Innate biology versus lifestyle behaviour in the aetiology of obesity and type 2 diabetes: the GLACIER Study
Poveda, Alaitz, Koivula, Robert W., Ahmad, Shafqat, Barroso, Inês, Hallmans, Göran, Johansson, Ingegerd, Renström, Frida, Franks, Paul W.
Published in Diabetologia (01.03.2016)
Published in Diabetologia (01.03.2016)
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Journal Article
189-OR: Plasma Proteome Profiling of Prediabetes and Diabetes Progression: An IMI Direct Study
HONG, MUN-GWAN, VIÑUELA, ANA, HÄUSSLER, RAGNA S., DALE, MATILDA, KOIVULA, ROBERT W., FERNANDEZ-TAJES, JUAN, MAHAJAN, ANUBHA, BIZZOTTO, ROBERTO, MARI, ANDREA, DERMITZAKIS, EMMANOUIL, MCCARTHY, MARK, FRANKS, PAUL W., PEARSON, EWAN, SCHWENK, JOCHEN M.
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Journal Article
1845-P: Divergent Effects on T2D of Alleles Associated with Increased Liver Fat Reflect Differential Impact on Hepatic Glucose and Lipid Output: An IMI DIRECT Study
KOIVULA, ROBERT W., CONSORTIUM, IMI-DIRECT, FRANKS, PAUL W., HANSEN, TUE H., LAAKSO, MARKKU, PEARSON, EWAN, RUTTERS, FEMKE, KARPE, FREDRIK, TOMLINSON, JEREMY W., MAHAJAN, ANUBHA, MCCARTHY, MARK
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Journal Article
Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study
Renström, Frida, Koivula, Robert W., Varga, Tibor V., Hallmans, Göran, Mulder, Hindrik, Florez, Jose C., Hu, Frank B., Franks, Paul W.
Published in Diabetologia (01.05.2015)
Published in Diabetologia (01.05.2015)
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