Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[ b]thiophenes
Takeuchi, Kumiko, Kohn, Todd J., Sall, Daniel J., Denney, Michael L., McCowan, Jefferson R., Smith, Gerry F., Gifford-Moore, Donetta S.
Published in Bioorganic & medicinal chemistry letters (08.03.1999)
Published in Bioorganic & medicinal chemistry letters (08.03.1999)
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Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation
Sall, Daniel J, Bastian, Jolie A, Briggs, Stephen L, Buben, John A, Chirgadze, Nickolay Y, Clawson, David K, Denney, Michael L, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Hauser, Kenneth L, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Smith, Gerald F, Takeuchi, Kumiko, Thrasher, Kenneth J, Tinsley, Jennifer M, Utterback, Barbara G, Yan, Sau-Chi B, Zhang, Minsheng
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives
Sall, Daniel J, Bailey, Dianna L, Bastian, Jolie A, Buben, John A, Chirgadze, Nickolay Y, Clemens-Smith, Amy C, Denney, Michael L, Fisher, Matthew J, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Johnson, Lea M, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Richett, Michael E, Smith, Gerald F, Snyder, David W, Takeuchi, Kumiko, Toth, John E, Zhang, Minsheng
Published in Journal of medicinal chemistry (24.02.2000)
Published in Journal of medicinal chemistry (24.02.2000)
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Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted ω-Phenyl-ω-(3-pyridyl)alkenoic Acid Derivatives and Related Compounds
Takeuchi, Kumiko, Kohn, Todd J, True, Timothy A, Mais, Dale E, Wikel, James H, Utterback, Barbara G, Wyss, Virginia L, Jakubowski, Joseph A
Published in Journal of medicinal chemistry (31.12.1998)
Published in Journal of medicinal chemistry (31.12.1998)
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Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4'-side chain analogues
TAKEUCHI, K, KOHN, T. J, HARPER, R. W, LIN, H.-S, GIFFORD-MOORE, D. S, RICHETT, M. E, SALL, D. J, SMITH, G. F, MINSHENG ZHANG
Published in Bioorganic & medicinal chemistry letters (05.06.2000)
Published in Bioorganic & medicinal chemistry letters (05.06.2000)
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Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives
Takeuchi, Kumiko, Kohn, Todd J, Mais, Dale E, True, Timothy A, Wyss, Virginia L, Jakubowski, Joseph A
Published in Bioorganic & medicinal chemistry letters (04.08.1998)
Published in Bioorganic & medicinal chemistry letters (04.08.1998)
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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2: sidechain optimization and demonstration of in vivo efficacy
Zhang, Minsheng, Bailey, Dianna L., Bastian, Jolie A., Briggs, Stephen L., Chirgadze, Nickolay Y., Clawson, David K., Denney, Michael L., Gifford-Moore, Donetta S., Harper, Richard W., Johnson, Lea M., Klimkowski, Valentine J., Kohn, Todd J., Lin, Ho-Shen, McCowan, Jefferson R., Richett, Michael E., Sall, Daniel J., Smith, Amy J., Smith, Gerald F., Snyder, David W., Takeuchi, Kumiko, Utterback, Barbara G., Yan, Sau-Chi B.
Published in Bioorganic & medicinal chemistry letters (08.03.1999)
Published in Bioorganic & medicinal chemistry letters (08.03.1999)
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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4
ROCCO, Vincent P, SPINAZZE, Patrick G, TAKEUCHI, Kumiko, KOHN, Todd J, HONIGSCHMIDT, Nicholas A, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
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Advances toward new antidepressants beyond SSRIs : 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5
TAKEUCHI, Kumiko, KOHN, Todd J, LODGE, David, MARTIN, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, HEMRICK-LUECKE, Susan K, THOMPSON, Linda K, EVANS, David C, RASMUSSEN, Kurt, KOGER, Deanna
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1
TAKEUCHI, Kumiko, KOHN, Todd J, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, KOCH, Daniel J, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J, SHAW, Janice
Published in Bioorganic & medicinal chemistry letters (02.06.2003)
Published in Bioorganic & medicinal chemistry letters (02.06.2003)
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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3
TAKEUCHI, Kumiko, KOHN, Todd J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, ATKINSON, Steven T, HERTEL, Larry W, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2
TAKEUCHI, Kumiko, KOHN, Todd J, AHMAD, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, KOCH, Daniel J, ATKINSON, Steven T, HERTEL, Larry W, NELSON, David L, WAINSCOTT, D. Bradley
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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