Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis
Mallaney, Cates, Ostrander, Elizabeth L, Celik, Hamza, Kramer, Ashley C, Martens, Andrew, Kothari, Alok, Koh, Won Kyun, Haussler, Emily, Iwamori, Naoki, Gontarz, Paul, Zhang, Bo, Challen, Grant A
Published in Leukemia (01.10.2019)
Published in Leukemia (01.10.2019)
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Journal Article
Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness
Ostrander, Elizabeth L., Kramer, Ashley C., Mallaney, Cates, Celik, Hamza, Koh, Won Kyun, Fairchild, Jake, Haussler, Emily, Zhang, Christine R.C., Challen, Grant A.
Published in Stem cell reports (14.04.2020)
Published in Stem cell reports (14.04.2020)
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Journal Article
Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21
Zhang, Christine R, Ostrander, Elizabeth L, Kukhar, Ostap, Mallaney, Cates, Sun, Jiameng, Haussler, Emily, Celik, Hamza, Koh, Won Kyun, King, Katherine Y, Gontarz, Paul, Challen, Grant A
Published in Blood cancer discovery (05.05.2022)
Published in Blood cancer discovery (05.05.2022)
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Journal Article
Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis
Lin, Pei-Yi, Simon, Sharotka M, Koh, Won Kyun, Folorunso, Oluwarotimi, Umbaugh, C Samuel, Pierce, Anson
Published in Molecular neurodegeneration (21.11.2013)
Published in Molecular neurodegeneration (21.11.2013)
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Journal Article
DNMT3A Mutations Enhance T-ALL Survival, Which Is Reversed By JAK/STAT Inhibition
Dunuwille, Wangisa M.B., Wilson, William Casey, Issa, Nancy, Koh, Won Kyun, Han, Wentao, Challen, Grant A
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
DNMT3A Regulates Hematopoietic Stem Cell Function Via DNA Methylation-Independent Functions
Koh, Won Kyun, Celik, Hamza, Tao, Jacob, Fairchild, Jake, Kukhar, Ostap, Zhang, Christine R, Gontarz, Paul, Challen, Grant A.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
The Histone Demethylase KDM6B Is a Genetic Dependency of NOTCH1-Driven T-ALL
Issa, Nancy, Celik, Hamza, Bjeije, Hassan, Dunuwille, Wangisa M.B., Koh, Won Kyun, Parsons, Tyler, Zhang, Christine R, Han, Wentao, Challen, Grant A.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Txnip enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells Via p21
Zhang, Christine R, Ostrander, Elizabeth Leigh, Sun, Jiameng, Mallaney, Cates, Celik, Hamza, Koh, Won Kyun, King, Katherine Y., Gontarz, Paul, Challen, Grant A.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells
Celik, Hamza, Koh, Won Kyun, Kramer, Ashley C., Ostrander, Elizabeth L., Mallaney, Cates, Fisher, Daniel A.C., Xiang, Jingyu, Wilson, William C., Martens, Andrew, Kothari, Alok, Fishberger, Gregory, Tycksen, Eric, Karpova, Darja, Duncavage, Eric J., Lee, Youngsook, Oh, Stephen T., Challen, Grant A.
Published in Cancer cell (12.11.2018)
Published in Cancer cell (12.11.2018)
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Journal Article
3042 – TXNIP ENHANCES FITNESS OF DNMT3A-MUTANT HEMATOPOIETIC STEM CELLS VIA P21
Zhang, Christine, Ostrander, Elizabeth, Sun, Jiameng, Mallaney, Cates, Haussler, Emily, Celik, Hamza, Kuhkar, Ostap, Koh, Won Kyun, King, Katherine, Challen, Grant
Published in Experimental hematology (01.08.2021)
Published in Experimental hematology (01.08.2021)
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Journal Article
3225 – DNA METHYLATION-INDEPENDENT FUNCTIONS OF DNMT3A REGULATE HEMATOPOIETIC STEM CELL FUNCTION
Raj, Infencia Xavier, Koh, Won Kyun, Harrison, Jessica, Zhang, Christine, Arand, Jason, Bjeije, Hassan, Han, Wentao, Young, Andrew, Dunuwille, Wangisa, Krishnan, Aishwarya, Parsons, Tyler, Burkart, Sammi, Wang, Ting, Challen, Grant
Published in Experimental hematology (2023)
Published in Experimental hematology (2023)
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Journal Article
A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Celik, Hamza, Krug, Ethan, Zhang, Christine R, Han, Wentao, Issa, Nancy, Koh, Won Kyun, Bjeije, Hassan, Kukhar, Ostap, Allen, Maggie, Li, Tiandao, Fisher, Daniel A C, Fowles, Jared S, Wong, Terrence N, Stubbs, Matthew C, Koblish, Holly K, Oh, Stephen T, Challen, Grant A
Published in Cancer discovery (01.12.2021)
Published in Cancer discovery (01.12.2021)
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Journal Article
A Novel Humanized Animal Model Reveals Clonal Architecture and Therapeutic Vulnerabilities in Myelofibrosis
Celik, Hamza, Krug, Ethan, Bjeije, Hassan, Issa, Nancy, Han, Wentao, Kyun Koh, Won, Zhang, Ruochao CZ, Allen, Maggie J., Wong, Terrence N, Fisher, Daniel AC, Li, Tiandao, Oh, Stephen T., Challen, Grant A.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Abstract LB555: Augmented Txnip-p53-p21 axis preserves Dnmt3a mutant hematopoietic stem cells during inflammatory stress
Zhang, Christine R., Ostrander, Elizabeth, Koh, Won Kyun, kukhar, Ostap, Celik, Hamza, Magee, Jeffrey, Challen, Grant
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Jarid2 Restricts Long-Term Repopulating Stem Cell Capacity in Multipotent Progenitors and Acts As Tumor Suppressor in Chronic Myeloid Neoplasms
Celik, Hamza, Kyun Koh, Won, Ostrander, Elizabeth Leigh, Kramer, Ashley C., Wilson, William C, Fishberger, Greg, Mallaney, Cates, Kothari, Alok, Challen, Grant Anthony
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
14-3-3 Proteins Restrain the Exo1 Nuclease to Prevent Overresection
Chen, Xiaoqing, Kim, In-Kwon, Honaker, Yuchi, Paudyal, Sharad C., Koh, Won Kyun, Sparks, Melanie, Li, Shan, Piwnica-Worms, Helen, Ellenberger, Tom, You, Zhongsheng
Published in The Journal of biological chemistry (08.05.2015)
Published in The Journal of biological chemistry (08.05.2015)
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Journal Article
The GNASR201C mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity
Ostrander, Elizabeth L., Koh, Won Kyun, Mallaney, Cates, Kramer, Ashley C., Wilson, W. Casey, Zhang, Bo, Challen, Grant A.
Published in Experimental hematology (01.01.2018)
Published in Experimental hematology (01.01.2018)
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Journal Article
The GNAS R201C mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity
Ostrander, Elizabeth L, Koh, Won Kyun, Mallaney, Cates, Kramer, Ashley C, Wilson, W Casey, Zhang, Bo, Challen, Grant A
Published in Experimental hematology (01.01.2018)
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Published in Experimental hematology (01.01.2018)
Journal Article
A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Celik, Hamza, Krug, Ethan, Zhang, Christine Rc, Han, Wentao, Issa, Nancy, Koh, Won Kyun, Bjeije, Hassan, Kukhar, Ostap, Allen, Maggie, Li, Tindao, Daniel Ac Fisher, Fowles, Jared, Wong, Terrence N, Stubbs, Matthew C, Koblish, Holly K, Oh, Stephen T, Challen, Grant A
Published in bioRxiv (12.11.2020)
Published in bioRxiv (12.11.2020)
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