The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression
Wallez, Yann, Dunlop, Charles R, Johnson, Timothy Isaac, Koh, Siang-Boon, Fornari, Chiara, Yates, James W T, Bernaldo de Quirós Fernández, Sandra, Lau, Alan, Richards, Frances M, Jodrell, Duncan I
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
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Journal Article
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors
Qiao, Shuxi, Koh, Siang-Boon, Vivekanandan, Varunika, Salunke, Devika, Patra, Krushna Chandra, Zaganjor, Elma, Ross, Kenneth, Mizukami, Yusuke, Jeanfavre, Sarah, Chen, Athena, Mino-Kenudson, Mari, Ramaswamy, Sridhar, Clish, Clary, Haigis, Marcia, Bardeesy, Nabeel, Ellisen, Leif W
Published in Genes & development (01.06.2020)
Published in Genes & development (01.06.2020)
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Journal Article
Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine
Koh, Siang-Boon, Wallez, Yann, Dunlop, Charles R, Bernaldo de Quirós Fernández, Sandra, Bapiro, Tashinga E, Richards, Frances M, Jodrell, Duncan I
Published in Cancer research (Chicago, Ill.) (01.06.2018)
Published in Cancer research (Chicago, Ill.) (01.06.2018)
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Journal Article
Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair
Wang, Yumin, Gao, Boya, Zhang, Luyuan, Wang, Xudong, Zhu, Xiaolan, Yang, Haibo, Zhang, Fengqi, Zhu, Xueping, Zhou, Badi, Yao, Sean, Nagayama, Aiko, Lee, Sanghoon, Ouyang, Jian, Koh, Siang-Boon, Eisenhauer, Eric L, Zarrella, Dominique, Lu, Kate, Rueda, Bo R, Zou, Lee, Su, Xiaofeng A, Yeku, Oladapo, Ellisen, Leif W, Wang, Xiao-Song, Lan, Li
Published in Nature communications (21.02.2024)
Published in Nature communications (21.02.2024)
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Journal Article
Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy
Jackson, Robert C, Di Veroli, Giovanni Y, Koh, Siang-Boon, Goldlust, Ian, Richards, Frances M, Jodrell, Duncan I
Published in PLoS computational biology (01.05.2017)
Published in PLoS computational biology (01.05.2017)
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Journal Article
Prediction and identification of synergistic compound combinations against pancreatic cancer cells
KalantarMotamedi, Yasaman, Choi, Ran Joo, Koh, Siang-Boon, Bramhall, Jo L., Fan, Tai-Ping, Bender, Andreas
Published in iScience (24.09.2021)
Published in iScience (24.09.2021)
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Journal Article
Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses
Koh, Siang-Boon, Dontchos, Brian N, Bossuyt, Veerle, Edmonds, Christine, Cristea, Simona, Melkonjan, Nsan, Mortensen, Lindsey, Ma, Annie, Beyerlin, Kassidy, Denault, Elyssa, Niehoff, Elizabeth, Hirz, Taghreed, Sykes, David B, Michor, Franziska, Specht, Michelle, Lehman, Constance, Ellisen, Leif W, Spring, Laura M
Published in NPJ precision oncology (21.09.2021)
Published in NPJ precision oncology (21.09.2021)
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Journal Article
Curcumin Analogues with Potent and Selective Anti-proliferative Activity on Acute Promyelocytic Leukemia: Involvement of Accumulated Misfolded Nuclear Receptor Co-repressor (N-CoR) Protein as a Basis for Selective Activity
Tan, Kheng-Lin, Koh, Siang-Boon, Ee, Rachel Pui-Lai, Khan, Matiullah, Go, Mei-Lin
Published in ChemMedChem (01.09.2012)
Published in ChemMedChem (01.09.2012)
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Journal Article
RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer
Koh, Siang-Boon, Ross, Kenneth, Isakoff, Steven J, Melkonjan, Nsan, He, Lei, Matissek, Karina J, Schultz, Andrew, Mayer, Erica L, Traina, Tiffany A, Carey, Lisa A, Rugo, Hope S, Liu, Minetta C, Stearns, Vered, Langenbucher, Adam, Saladi, Srinivas Vinod, Ramaswamy, Sridhar, Lawrence, Michael S, Ellisen, Leif W
Published in Clinical cancer research (01.09.2021)
Published in Clinical cancer research (01.09.2021)
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Journal Article
Author Correction: Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair
Wang, Yumin, Gao, Boya, Zhang, Luyuan, Wang, Xudong, Zhu, Xiaolan, Yang, Haibo, Zhang, Fengqi, Zhu, Xueping, Zhou, Badi, Yao, Sean, Nagayama, Aiko, Lee, Sanghoon, Ouyang, Jian, Koh, Siang-Boon, Eisenhauer, Eric L, Zarrella, Dominique, Lu, Kate, Rueda, Bo R, Zou, Lee, Su, Xiaofeng A, Yeku, Oladapo, Ellisen, Leif W, Wang, Xiao-Song, Lan, Li
Published in Nature communications (07.05.2024)
Published in Nature communications (07.05.2024)
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Journal Article
An automated fitting procedure and software for dose-response curves with multiphasic features
Di Veroli, Giovanni Y, Fornari, Chiara, Goldlust, Ian, Mills, Graham, Koh, Siang Boon, Bramhall, Jo L, Richards, Frances M, Jodrell, Duncan I
Published in Scientific reports (01.10.2015)
Published in Scientific reports (01.10.2015)
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Journal Article
Abstract P2-21-01: Feasibility of a multidisciplinary diagnostic breast research biopsy project
Beyerlin, Kassidy, Edmonds, Christine, Koh, Siang Boon, Bossuyt, Veerle, Ma, Annie, Jimenez, Rachel, Specht, Michelle, Smith, Barbara L, Dontchos, Brian, Sgroi, Dennis, Isakoff, Steven J, Lehman, Constance, Ellisen, Leif W, Spring, Laura M
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Journal Article
Mathematical imaging methods for mitosis analysis in live-cell phase contrast microscopy
Grah, Joana Sarah, Harrington, Jennifer Alison, Koh, Siang Boon, Pike, Jeremy Andrew, Schreiner, Alexander, Burger, Martin, Schönlieb, Carola-Bibiane, Reichelt, Stefanie
Published in Methods (San Diego, Calif.) (15.02.2017)
Published in Methods (San Diego, Calif.) (15.02.2017)
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Journal Article
Abstract 3497: Mechanism-based scheduling of triple therapy gemcitabine/CHK1i/WEE1i in pancreatic cancer at submaximal yet synergistic concentrations
Koh, Siang-Boon, Richards, Frances M., Rodriguez, Esther, Lyons, Scott K., Jodrell, Duncan I.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article