Discovery and SAR of 4-aminopyrrolidine-2-carboxylic acid correctors of CFTR for the treatment of cystic fibrosis
Scanio, Marc J.C., Searle, Xenia B., Liu, Bo, Koenig, John R., Altenbach, Robert J., Gfesser, Gregory A., Bogdan, Andrew, Greszler, Stephen, Zhao, Gang, Singh, Ashvani, Fan, Yihong, Swensen, Andrew M., Vortherms, Timothy, Manelli, Arlene, Balut, Corina, Gao, Wenqing, Yong, Hong, Schrimpf, Michael, Tse, Chris, Kym, Philip, Wang, Xueqing
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Get full text
Journal Article
Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis
Scanio, Marc J. C, Searle, Xenia B, Liu, Bo, Koenig, John R, Altenbach, Robert, Gfesser, Gregory A, Bogdan, Andrew, Greszler, Stephen, Zhao, Gang, Singh, Ashvani, Fan, Yihong, Swensen, Andrew M, Vortherms, Timothy, Manelli, Arlene, Balut, Corina, Jia, Ying, Gao, Wenqing, Yong, Hong, Schrimpf, Michael, Tse, Chris, Kym, Philip, Wang, Xueqing
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
Get full text
Journal Article
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists
Perner, Richard J., Koenig, John R., DiDomenico, Stanley, Gomtsyan, Arthur, Schmidt, Robert G., Lee, Chih-Hung, Hsu, Margaret C., McDonald, Heath A., Gauvin, Donna M., Joshi, Shailen, Turner, Teresa M., Reilly, Regina M., Kym, Philip R., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (01.07.2010)
Published in Bioorganic & medicinal chemistry (01.07.2010)
Get full text
Journal Article
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
Puttfarcken, Pamela S., Han, Ping, Joshi, Shailen K., Neelands, Torben R., Gauvin, Donna M., Baker, Scott J., Lewis, La Geisha R., Bianchi, Bruce R., Mikusa, Joseph P., Koenig, John R., Perner, Richard J., Kort, Michael E., Honore, Prisca, Faltynek, Connie R., Kym, Philip R., Reilly, Regina M.
Published in Pain (Amsterdam) (01.08.2010)
Published in Pain (Amsterdam) (01.08.2010)
Get full text
Journal Article
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists
Schmidt, Robert G., Bayburt, Erol K., Latshaw, Steven P., Koenig, John R., Daanen, Jerome F., McDonald, Heath A., Bianchi, Bruce R., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Lee, Chih-Hung, Faltynek, Connie R., Gomtsyan, Arthur
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Get full text
Journal Article
Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties
Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Zheng, Guo Zhu, Perner, Richard J, Didomenico, Stanley, Koenig, John R, Turner, Sean, Jinkerson, Tammie, Drizin, Irene, Hannick, Steven M, Macri, Bryan S, McDonald, Heath A, Honore, Prisca, Wismer, Carol T, Marsh, Kennan C, Wetter, Jill, Stewart, Kent D, Oie, Tetsuro, Jarvis, Michael F, Surowy, Carol S, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (10.02.2005)
Published in Journal of medicinal chemistry (10.02.2005)
Get full text
Journal Article
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists
Brown, Brian S., Keddy, Ryan, Zheng, Guo Zhu, Schmidt, Robert G., Koenig, John R., McDonald, Heath A., Bianchi, Bruce R., Honore, Prisca, Jarvis, Michael F., Surowy, Carol S., Polakowski, James S., Marsh, Kennan C., Faltynek, Connie R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
Get full text
Journal Article
Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: Effects of substitution about the rigidifying ring
KOENIG, John R, HUAQING LIU, BRIONI, Jorge D, COWART, Marlon, DRIZIN, Irene, WITTE, David G, CARR, Tracy L, MANELLI, Arlene M, MILICIC, Ivan, STRAKHOVA, Marina I, MILLER, Thomas R, ESBENSHADE, Timothy A
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Get full text
Journal Article
Discovery of TRPV1 antagonist ABT-116
Brown, Brian S, Keddy, Ryan, Perner, Richard J, DiDomenico, Stanley, Koenig, John R, Jinkerson, Tammie K, Hannick, Steven M, McDonald, Heath A, Bianchi, Bruce R, Honore, Prisca, Puttfarcken, Pamela S, Moreland, Robert B, Marsh, Kennan C, Faltynek, Connie R, Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Get full text
Journal Article
α-Methylation at benzylic fragment of N-aryl- N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model
Gomtsyan, Arthur, Bayburt, Erol K., Keddy, Ryan, Turner, Sean C., Jinkerson, Tammie K., Didomenico, Stanley, Perner, Richard J., Koenig, John R., Drizin, Irene, McDonald, Heath A., Surowy, Carol S., Honore, Prisca, Mikusa, Joe, Marsh, Kennan C., Wetter, Jill M., Faltynek, Connie R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Get full text
Journal Article
In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists
Perner, Richard J, DiDomenico, Stanley, Koenig, John R, Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Drizin, Irene, Zheng, Guo Zhu, Turner, Sean C, Jinkerson, Tammie, Brown, Brian S, Keddy, Ryan G, Lukin, Kurill, McDonald, Heath A, Honore, Prisca, Mikusa, Joe, Marsh, Kennan C, Wetter, Jill M, St. George, Karen, Jarvis, Michael F, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
Get full text
Journal Article
Structure–activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists
Drizin, Irene, Gomtsyan, Arthur, Bayburt, Erol K., Schmidt, Robert G., Zheng, Guo Zhu, Perner, Richard J., DiDomenico, Stanley, Koenig, John R., Turner, Sean C., Jinkerson, Tammie K., Brown, Brian S., Keddy, Ryan G., McDonald, Heath A., Honore, Prisca, Wismer, Carol T., Marsh, Kennan C., Wetter, Jill M., Polakowski, James S., Segreti, Jason A., Jarvis, Michael F., Faltynek, Connie R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry (15.07.2006)
Published in Bioorganic & medicinal chemistry (15.07.2006)
Get full text
Journal Article
Differentiation of Amphetamine/Methamphetamine and Other Cross-Immunoreactive Sympathomimetic Amines in Urine Samples by Serial Dilution Testing
Woodworth, Alison, Saunders, Al N, Koenig, John W, Moyer, Thomas P, Turk, John, Dietzen, Dennis J
Published in Clinical chemistry (Baltimore, Md.) (01.04.2006)
Published in Clinical chemistry (Baltimore, Md.) (01.04.2006)
Get full text
Journal Article
Adenosine kinase inhibitors: polar 7-Substitutent of pyridopyrimidine derivatives improving their locomotor selectivity
Zheng, Guo Zhu, Mao, Yue, Lee, Chih-Hung, Pratt, John K., Koenig, John R., Perner, Richard J., Cowart, Marlon D., Gfesser, Gregory A., McGaraughty, Steve, Chu, Katharine L., Zhu, Chang, Yu, Haixia, Kohlhaas, Kathy, Alexander, Karen M., Wismer, Carol T., Mikusa, Joseph, Jarvis, Michael F., Kowaluk, Elizabeth A., Stewart, Andrew O.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Get full text
Journal Article
Pyridopyrimidine analogues as novel adenosine kinase inhibitors
Zheng, Guo Zhu, Lee, Chih-Hung, Pratt, John K, Perner, Richard J, Jiang, Mei Qun, Gomtsyan, Arthur, Matulenko, Mark A, Mao, Yui, Koenig, John R, Kim, Ki H, Muchmore, Steve, Yu, Haixia, Kohlhaas, Kathy, Alexander, Karen M, McGaraughty, Steve, Chu, Katharine L, Wismer, Carol T, Mikusa, Joseph, Jarvis, Michael F, Marsh, Kennan, Kowaluk, Elizabeth A, Bhagwat, Shripad S, Stewart, Andrew O
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Get full text
Journal Article
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl) pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na(v)1.7/Nav1.8 blockers for the treatment of pain
Patel, Meena, Peltier, Hillary M., Matulenko, Mark A., Koenig, John R., Scanio, Marc J. C., Gum, Rebecca J., El-Kouhen, Odile F., Fricano, Meagan M., Lundgaard, Greta L., Neelands, Torben, Zhang, Xu-Feng, Zhan, Cenchen, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Hudzik, Thomas, Gintant, Gary, Martin, Ruth, McGaraughty, Steve, Xu, Jun, Bow, Daniel, Kalvass, John C., Kym, Philip R., DeGoey, David A., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (01.06.2022)
Published in Bioorganic & medicinal chemistry (01.06.2022)
Get full text
Journal Article
Golden Gate: Bridging The Resource-Efficiency Gap Between ASICs and FPGA Prototypes
Magyar, Albert, Biancolin, David, Koenig, John, Seshia, Sanjit, Bachrach, Jonathan, Asanovic, Krste
Published in 2019 IEEE/ACM International Conference on Computer-Aided Design (ICCAD) (01.11.2019)
Published in 2019 IEEE/ACM International Conference on Computer-Aided Design (ICCAD) (01.11.2019)
Get full text
Conference Proceeding
SUBSTITUTED CHROMANES AND METHOD OF USE
KYM PHILIP R, ALTENBACH ROBERT J, SEARLE XENIA B, LIU BO, WANG XUEQING, YEUNG MING C, KOENIG JOHN R, VOIGHT ERIC, GRESZLER STEPHEN N, BOGDAN ANDREW
Year of Publication 22.03.2023
Get full text
Year of Publication 22.03.2023
Patent
SUBSTITUTED CHROMANES AND METHOD OF USE
KYM PHILIP R, ALTENBACH ROBERT J, SEARLE XENIA B, LIU BO, WANG XUEQING, YEUNG MING C, KOENIG JOHN R, VOIGHT ERIC, GRESZLER STEPHEN N, BOGDAN ANDREW
Year of Publication 11.11.2022
Get full text
Year of Publication 11.11.2022
Patent