Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation
Provençal, Nadine, Arloth, Janine, Cattaneo, Annamaria, Anacker, Christoph, Cattane, Nadia, Wiechmann, Tobias, Röh, Simone, Ködel, Maik, Klengel, Torsten, Czamara, Darina, Müller, Nikola S., Lahti, Jari, Räikkönen, Katri, Pariante, Carmine M., Binder, Elisabeth B.
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (22.09.2020)
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Journal Article
Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk
Zannas, Anthony S., Jia, Meiwen, Hafner, Kathrin, Baumert, Jens, Wiechmann, Tobias, Pape, Julius C., Arloth, Janine, Ködel, Maik, Martinelli, Silvia, Roitman, Maria, Röh, Simone, Haehle, Andreas, Emeny, Rebecca T., Iurato, Stella, Carrillo-Roa, Tania, Lahti, Jari, Räikkönen, Katri, Eriksson, Johan G., Drake, Amanda J., Waldenberger, Melanie, Wahl, Simone, Kunze, Sonja, Lucae, Susanne, Bradley, Bekh, Gieger, Christian, Hausch, Felix, Smith, Alicia K., Ressler, Kerry J., Müller-Myhsok, Bertram, Ladwig, Karl-Heinz, Rein, Theo, Gassen, Nils C., Binder, Elisabeth B.
Published in Proceedings of the National Academy of Sciences - PNAS (04.06.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (04.06.2019)
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Journal Article
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study
Cruceanu, Cristiana, Dony, Leander, Krontira, Anthi C, Fischer, David S, Roeh, Simone, Di Giaimo, Rossella, Kyrousi, Christina, Kaspar, Lea, Arloth, Janine, Czamara, Darina, Gerstner, Nathalie, Martinelli, Silvia, Wehner, Stefanie, Breen, Michael S, Koedel, Maik, Sauer, Susann, Sportelli, Vincenza, Rex-Haffner, Monika, Cappello, Silvia, Theis, Fabian J, Binder, Elisabeth B
Published in The American journal of psychiatry (01.05.2022)
Published in The American journal of psychiatry (01.05.2022)
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CELL-TYPE SPECIFIC AGEING EFFECTS IN THE HUMAN ORBITOFRONTAL CORTEX AND IMPLICATIONS FOR PSYCHIATRIC DISEASE
Fröhlich, Anna S, Gerstner, Nathalie, Gagliardi, Miriam, Koedel, Maik, Matosin, Natalie, Yusupov, Natan, Murek, Vanessa, Czamara, Darina, Roeh, Simone, Arloth, Janine, Ziller, Michael J, Binder, Elisabeth B
Published in European neuropsychopharmacology (01.10.2023)
Published in European neuropsychopharmacology (01.10.2023)
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Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease
Fröhlich, Anna S., Gerstner, Nathalie, Gagliardi, Miriam, Ködel, Maik, Yusupov, Natan, Matosin, Natalie, Czamara, Darina, Sauer, Susann, Roeh, Simone, Murek, Vanessa, Chatzinakos, Chris, Daskalakis, Nikolaos P., Knauer-Arloth, Janine, Ziller, Michael J., Binder, Elisabeth B.
Published in Nature neuroscience (03.09.2024)
Published in Nature neuroscience (03.09.2024)
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Journal Article
DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans
Yusupov, Natan, Roeh, Simone, Sotillos Elliott, Laura, Chang, Simon, Loganathan, Srivaishnavi, Urbina-Treviño, Lidia, Fröhlich, Anna S., Sauer, Susann, Ködel, Maik, Matosin, Natalie, Czamara, Darina, Deussing, Jan M., Binder, Elisabeth B.
Published in Molecular psychiatry (01.05.2024)
Published in Molecular psychiatry (01.05.2024)
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Dissecting depression symptoms: Multi-omics clustering uncovers immune-related subgroups and cell-type specific dysregulation
Hagenberg, Jonas, Brückl, Tanja M., Erhart, Mira, Kopf-Beck, Johannes, Ködel, Maik, Rehawi, Ghalia, Röh-Karamihalev, Simone, Sauer, Susann, Yusupov, Natan, Rex-Haffner, Monika, Spoormaker, Victor I., Sämann, Philipp, Binder, Elisabeth, Knauer-Arloth, Janine
Published in Brain, behavior, and immunity (01.01.2025)
Published in Brain, behavior, and immunity (01.01.2025)
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Extensive evaluation of DNA methylation of functional elements in the murine Fkbp5 locus using high‐accuracy DNA methylation measurement via targeted bisulfite sequencing
Yusupov, Natan, Doeselaar, Lotte, Röh, Simone, Wiechmann, Tobias, Ködel, Maik, Sauer, Susann, Rex‐Haffner, Monika, Schmidt, Mathias V., Binder, Elisabeth B.
Published in The European journal of neuroscience (01.08.2023)
Published in The European journal of neuroscience (01.08.2023)
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Journal Article
High-throughput screening of glucocorticoid-induced enhancer activity reveals mechanisms of stress-related psychiatric disorders
Penner-Goeke, Signe, Bothe, Melissa, Rek, Nils, Kreitmaier, Peter, Pöhlchen, Dorothee, Kühnel, Anne, Glaser, Laura V, Kaya, Ezgi, Krontira, Anthi C, Röh, Simone, Czamara, Darina, Ködel, Maik, Monteserin-Garcia, Jose, Diener, Laura, Wölfel, Barbara, Sauer, Susann, Rummel, Christine, Riesenberg, Stephan, Arloth-Knauer, Janine, Ziller, Michael, Labeur, Marta, Meijsing, Sebastiaan, Binder, Elisabeth B
Published in Proceedings of the National Academy of Sciences - PNAS (05.12.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (05.12.2023)
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Journal Article
Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression
Krontira, Anthi C., Cruceanu, Cristiana, Dony, Leander, Kyrousi, Christina, Link, Marie-Helen, Rek, Nils, Pöhlchen, Dorothee, Raimundo, Catarina, Penner-Goeke, Signe, Schowe, Alicia, Czamara, Darina, Lahti-Pulkkinen, Marius, Sammallahti, Sara, Wolford, Elina, Heinonen, Kati, Roeh, Simone, Sportelli, Vincenza, Wölfel, Barbara, Ködel, Maik, Sauer, Susann, Rex-Haffner, Monika, Räikkönen, Katri, Labeur, Marta, Cappello, Silvia, Binder, Elisabeth B.
Published in Neuron (Cambridge, Mass.) (01.05.2024)
Published in Neuron (Cambridge, Mass.) (01.05.2024)
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Journal Article
192. Investigation of Prenatal Stress in the Cerebral Organoid Model: A Focus on Cell-Type Specific Responses Following Glucocorticoid Exposure
Cruceanu, Cristiana, Roeh, Simone, Wehner, Stefanie, Martinelli, Silvia, Koedel, Maik, Di Giaimo, Rossella, Cappello, Silvia, Binder, Elisabeth
Published in Biological psychiatry (1969) (01.05.2018)
Published in Biological psychiatry (1969) (01.05.2018)
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Journal Article
Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
Matosin, Natalie, Arloth, Janine, Czamara, Darina, Edmond, Katrina Z., Maitra, Malosree, Fröhlich, Anna S., Martinelli, Silvia, Kaul, Dominic, Bartlett, Rachael, Curry, Amber R., Gassen, Nils C., Hafner, Kathrin, Müller, Nikola S., Worf, Karolina, Rehawi, Ghalia, Nagy, Corina, Halldorsdottir, Thorhildur, Cruceanu, Cristiana, Gagliardi, Miriam, Gerstner, Nathalie, Ködel, Maik, Murek, Vanessa, Ziller, Michael J., Scarr, Elizabeth, Tao, Ran, Jaffe, Andrew E., Arzberger, Thomas, Falkai, Peter, Kleinmann, Joel E., Weinberger, Daniel R., Mechawar, Naguib, Schmitt, Andrea, Dean, Brian, Turecki, Gustavo, Hyde, Thomas M., Binder, Elisabeth B.
Published in Acta neuropathologica (01.04.2023)
Published in Acta neuropathologica (01.04.2023)
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Journal Article
Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Wiechmann, Tobias, Röh, Simone, Sauer, Susann, Czamara, Darina, Arloth, Janine, Ködel, Maik, Beintner, Madita, Knop, Lisanne, Menke, Andreas, Binder, Elisabeth B, Provençal, Nadine
Published in Clinical epigenetics (23.05.2019)
Published in Clinical epigenetics (23.05.2019)
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Journal Article
Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing
Czamara, Darina, Cruceanu, Cristiana, Lahti-Pulkkinen, Marius, Dieckmann, Linda, Ködel, Maik, Sauer, Susann, Rex-Haffner, Monika, Sammallahti, Sara, Kajantie, Eero, Laivuori, Hannele, Lahti, Jari, Räikkönen, Katri, Binder, Elisabeth B
Published in International journal of molecular sciences (28.09.2022)
Published in International journal of molecular sciences (28.09.2022)
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Journal Article
HAM-TBS: high-accuracy methylation measurements via targeted bisulfite sequencing
Roeh, Simone, Wiechmann, Tobias, Sauer, Susann, Ködel, Maik, Binder, Elisabeth B, Provençal, Nadine
Published in Epigenetics & chromatin (04.07.2018)
Published in Epigenetics & chromatin (04.07.2018)
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Journal Article
Stress-induced brain responses are associated with BMI in women
Kühnel, Anne, Hagenberg, Jonas, Knauer-Arloth, Janine, Ködel, Maik, Czisch, Michael, Sämann, Philipp G., Binder, Elisabeth B., Kroemer, Nils B.
Published in Communications biology (11.10.2023)
Published in Communications biology (11.10.2023)
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Journal Article
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids
Dony, Leander, Krontira, Anthi C, Kaspar, Lea, Ruhel Ahmad, Ilknur Safak Demirel, Grochowicz, Malgorzata, Schaefer, Tim, Begum, Fatema, Sportelli, Vincenza, Raimundo, Catarina, Koedel, Maik, Labeur, Marta, Cappello, Silvia, Theis, Fabian J, Cruceanu, Cristiana, Binder, Elisabeth B
Published in bioRxiv (22.01.2024)
Published in bioRxiv (22.01.2024)
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Temporal regulation of ZBTB16 expression by glucocorticoids alters human cortical neurogenesis
Krontira, Anthi C, Cruceanu, Cristiana, Kyrousi, Christina, Dony, Leander, Link, Marie Helen, Kappelmann, Nils, Poehlchen, Dorothee, Roeh, Simone, Sportelli, Vincenza, Woelfel, Barbara, Koedel, Maik, Sauer, Susann, Rex-Haffner, Monika, Labeur, Marta, Cappello, Silvia, Binder, Elisabeth B
Published in bioRxiv (22.08.2022)
Published in bioRxiv (22.08.2022)
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