Valdecoxib: Assessment of Cyclooxygenase-2 Potency and Selectivity
Gierse, James K, Zhang, Yan, Hood, William F, Walker, Mark C, Trigg, Jennifer S, Maziasz, Timothy J, Koboldt, Carol M, Muhammad, Jerry L, Zweifel, Ben S, Masferrer, Jaime L, Isakson, Peter C, Seibert, Karen
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
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1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents
Khanna, Ish K, Weier, Richard M, Yu, Yi, Xu, Xiang D, Koszyk, Francis J, Collins, Paul W, Koboldt, Carol M, Veenhuizen, Amy W, Perkins, William E, Casler, Jacquelen J, Masferrer, Jaime L, Zhang, Yan Y, Gregory, Susan A, Seibert, Karen, Isakson, Peter C
Published in Journal of medicinal chemistry (23.05.1997)
Published in Journal of medicinal chemistry (23.05.1997)
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N-[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration
Talley, John J, Bertenshaw, Stephen R, Brown, David L, Carter, Jeffery S, Graneto, Matthew J, Kellogg, Michael S, Koboldt, Carol M, Yuan, Jinhua, Zhang, Yan Y, Seibert, Karen
Published in Journal of medicinal chemistry (04.05.2000)
Published in Journal of medicinal chemistry (04.05.2000)
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4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
Talley, John J, Brown, David L, Carter, Jeffery S, Graneto, Matthew J, Koboldt, Carol M, Masferrer, Jaime L, Perkins, William E, Rogers, Roland S, Shaffer, Alexander F, Zhang, Yan Y, Zweifel, Ben S, Seibert, Karen
Published in Journal of medicinal chemistry (09.03.2000)
Published in Journal of medicinal chemistry (09.03.2000)
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Kinetic basis for selective inhibition of cyclo-oxygenases
Gierse, J K, Koboldt, C M, Walker, M C, Seibert, K, Isakson, P C
Published in Biochemical journal (01.05.1999)
Published in Biochemical journal (01.05.1999)
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Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure−Activity Relationships
Huang, Horng-Chih, Li, James J, Garland, Danny J, Chamberlain, Timothy S, Reinhard, Emily J, Manning, Robert E, Seibert, Karen, Koboldt, Carol M, Gregory, Susan A, Anderson, Gary D, Veenhuizen, Amy W, Zhang, Yan, Perkins, William E, Burton, Earl G, Cogburn, J. Nita, Isakson, Peter C, Reitz, David B
Published in Journal of medicinal chemistry (05.01.1996)
Published in Journal of medicinal chemistry (05.01.1996)
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Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors
Carter, Jeffery S., Kramer, Steven, Talley, John J., Penning, Thomas, Collins, Paul, Graneto, Matthew J., Seibert, Karen, Koboldt, Carol M., Masferrer, Jaime, Zweifel, Ben
Published in Bioorganic & medicinal chemistry letters (19.04.1999)
Published in Bioorganic & medicinal chemistry letters (19.04.1999)
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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors
Walker, M C, Kurumbail, R G, Kiefer, J R, Moreland, K T, Koboldt, C M, Isakson, P C, Seibert, K, Gierse, J K
Published in Biochemical journal (01.08.2001)
Published in Biochemical journal (01.08.2001)
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Selective Cyclooxygenase-2 Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents
Khanna, Ish K, Yu, Yi, Huff, Renee M, Weier, Richard M, Xu, Xiangdong, Koszyk, Francis J, Collins, Paul W, Cogburn, J. Nita, Isakson, Peter C, Koboldt, Carol M, Masferrer, Jaime L, Perkins, William E, Seibert, Karen, Veenhuizen, Amy W, Yuan, Jinhua, Yang, Dai-Chang, Zhang, Yan Y
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2
Khanna, Ish K, Weier, Richard M, Yu, Yi, Collins, Paul W, Miyashiro, Julie M, Koboldt, Carol M, Veenhuizen, Amy W, Currie, Jerry L, Seibert, Karen, Isakson, Peter C
Published in Journal of medicinal chemistry (23.05.1997)
Published in Journal of medicinal chemistry (23.05.1997)
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A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and â2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors
Gierse, J K, McDonald, J J, Hauser, S D, Rangwala, S H, Koboldt, C M, Seibert, K
Published in The Journal of biological chemistry (28.06.1996)
Published in The Journal of biological chemistry (28.06.1996)
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Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents
Li, James J, Norton, Monica B, Reinhard, Emily J, Anderson, Gary D, Gregory, Susan A, Isakson, Peter C, Koboldt, Carol M, Masferrer, Jaime L, Perkins, William E, Seibert, Karen, Zhang, Yan, Zweifel, Ben S, Reitz, David B
Published in Journal of medicinal chemistry (26.04.1996)
Published in Journal of medicinal chemistry (26.04.1996)
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Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors
Carter, Jeffery S., Rogier, D.J., Graneto, Matthew J., Seibert, Karen, Koboldt, Carol M., Yan Zhang, Talley, John J.
Published in Bioorganic & medicinal chemistry letters (19.04.1999)
Published in Bioorganic & medicinal chemistry letters (19.04.1999)
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4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)
Talley, John J., Bertenshaw, Stephen R., Brown, David L., Carter, Jeffery S., Graneto, Mathew J., Koboldt, Carol M., Masferrer, Jaime L., Norman, Bryan H., Rogier Jr, D. Joseph, Zweifel, Ben S., Seibert, Karen
Published in Medicinal research reviews (01.05.1999)
Published in Medicinal research reviews (01.05.1999)
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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors
WALKER, Mark C., KURUMBAIL, Ravi G., KIEFER, James R., MORELAND, Kirby T., KOBOLDT, Carol M., ISAKSON, Peter C., SEIBERT, Karen, GIERSE, James K.
Published in Biochemical journal (01.08.2001)
Published in Biochemical journal (01.08.2001)
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Characterization of the Recombinant IKK1/IKK2 Heterodimer
Huynh, Q. Khai, Boddupalli, Hymavathi, Rouw, Sharon A., Koboldt, Carol M., Hall, Troii, Sommers, Cindy, Hauser, Scott D., Pierce, Jennifer L., Combs, Rodney G., Reitz, Beverly A., Diaz-Collier, Judy A., Weinberg, Robin A., Hood, Becky L., Kilpatrick, Bryan F., Tripp, Catherine S.
Published in The Journal of biological chemistry (01.08.2000)
Published in The Journal of biological chemistry (01.08.2000)
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Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
Penning, Thomas D, Talley, John J, Bertenshaw, Stephen R, Carter, Jeffery S, Collins, Paul W, Docter, Stephen, Graneto, Matthew J, Lee, Len F, Malecha, James W, Miyashiro, Julie M, Rogers, Roland S, Rogier, D. J, Yu, Stella S, Anderson, Gary D, Burton, Earl G, Cogburn, J. Nita, Gregory, Susan A, Koboldt, Carol M, Perkins, William E, Seibert, Karen, Veenhuizen, Amy W, Zhang, Yan Y, Isakson, Peter C
Published in Journal of medicinal chemistry (25.04.1997)
Published in Journal of medicinal chemistry (25.04.1997)
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Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity
Huynh, Q K, Boddupalli, H, Rouw, S A, Koboldt, C M, Hall, T, Sommers, C, Hauser, S D, Pierce, J L, Combs, R G, Reitz, B A, Diaz-Collier, J A, Weinberg, R A, Hood, B L, Kilpatrick, B F, Tripp, C S
Published in The Journal of biological chemistry (25.08.2000)
Published in The Journal of biological chemistry (25.08.2000)
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Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors
Reitz, David B., Li, James J., Norton, Monica B., Reinhard, Emily J., Collins, Joe T., Anderson, Gary D., Gregory, Susan A., Koboldt, Carol M., Perkins, William E.
Published in Journal of medicinal chemistry (01.11.1994)
Published in Journal of medicinal chemistry (01.11.1994)
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