Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning
Koblan, Luke W., Arbab, Mandana, Shen, Max W., Hussmann, Jeffrey A., Anzalone, Andrew V., Doman, Jordan L., Newby, Gregory A., Yang, Dian, Mok, Beverly, Replogle, Joseph M., Xu, Albert, Sisley, Tyler A., Weissman, Jonathan S., Adamson, Britt, Liu, David R.
Published in Nature biotechnology (01.11.2021)
Published in Nature biotechnology (01.11.2021)
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Journal Article
High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases
Bessen, Jeffrey L., Afeyan, Lena K., Dančík, Vlado, Koblan, Luke W., Thompson, David B., Leichner, Chas, Clemons, Paul A., Liu, David R.
Published in Nature communications (26.04.2019)
Published in Nature communications (26.04.2019)
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Journal Article
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity
Bachovchin, Daniel A, Koblan, Luke W, Wu, Wengen, Liu, Yuxin, Li, Youhua, Zhao, Peng, Woznica, Iwona, Shu, Ying, Lai, Jack H, Poplawski, Sarah E, Kiritsy, Christopher P, Healey, Sarah E, DiMare, Matthew, Sanford, David G, Munford, Robert S, Bachovchin, William W, Golub, Todd R
Published in Nature chemical biology (01.08.2014)
Published in Nature chemical biology (01.08.2014)
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Journal Article
Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases
Bessen, Jeffrey L., Afeyan, Lena K., Dančík, Vlado, Koblan, Luke W., Thompson, David B., Leichner, Chas, Clemons, Paul A., Liu, David R.
Published in Nature communications (02.07.2019)
Published in Nature communications (02.07.2019)
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Journal Article
Search-and-replace genome editing without double-strand breaks or donor DNA
Anzalone, Andrew V., Randolph, Peyton B., Davis, Jessie R., Sousa, Alexander A., Koblan, Luke W., Levy, Jonathan M., Chen, Peter J., Wilson, Christopher, Newby, Gregory A., Raguram, Aditya, Liu, David R.
Published in Nature (London) (01.12.2019)
Published in Nature (London) (01.12.2019)
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Journal Article
Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing
Anzalone, Andrew V., Gao, Xin D., Podracky, Christopher J., Nelson, Andrew T., Koblan, Luke W., Raguram, Aditya, Levy, Jonathan M., Mercer, Jaron A. M., Liu, David R.
Published in Nature biotechnology (01.05.2022)
Published in Nature biotechnology (01.05.2022)
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Journal Article
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
Richter, Michelle F., Zhao, Kevin T., Eton, Elliot, Lapinaite, Audrone, Newby, Gregory A., Thuronyi, B W., Wilson, Christopher, Koblan, Luke W., Zeng, Jing, Bauer, Daniel E., Doudna, Jennifer A., Liu, David R.
Published in Nature biotechnology (01.07.2020)
Published in Nature biotechnology (01.07.2020)
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Journal Article
Continuous evolution of base editors with expanded target compatibility and improved activity
Thuronyi, B W., Koblan, Luke W., Levy, Jonathan M., Yeh, Wei-Hsi, Zheng, Christine, Newby, Gregory A., Wilson, Christopher, Bhaumik, Mantu, Shubina-Oleinik, Olga, Holt, Jeffrey R., Liu, David R.
Published in Nature biotechnology (01.09.2019)
Published in Nature biotechnology (01.09.2019)
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Journal Article
Massively parallel assessment of human variants with base editor screens
Hanna, Ruth E., Hegde, Mudra, Fagre, Christian R., DeWeirdt, Peter C., Sangree, Annabel K., Szegletes, Zsofia, Griffith, Audrey, Feeley, Marissa N., Sanson, Kendall R., Baidi, Yossef, Koblan, Luke W., Liu, David R., Neal, James T., Doench, John G.
Published in Cell (18.02.2021)
Published in Cell (18.02.2021)
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Journal Article
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
Newby, Gregory A., Yen, Jonathan S., Woodard, Kaitly J., Mayuranathan, Thiyagaraj, Lazzarotto, Cicera R., Li, Yichao, Sheppard-Tillman, Heather, Porter, Shaina N., Yao, Yu, Mayberry, Kalin, Everette, Kelcee A., Jang, Yoonjeong, Podracky, Christopher J., Thaman, Elizabeth, Lechauve, Christophe, Sharma, Akshay, Henderson, Jordana M., Richter, Michelle F., Zhao, Kevin T., Miller, Shannon M., Wang, Tina, Koblan, Luke W., McCaffrey, Anton P., Tisdale, John F., Kalfa, Theodosia A., Pruett-Miller, Shondra M., Tsai, Shengdar Q., Weiss, Mitchell J., Liu, David R.
Published in Nature (London) (08.07.2021)
Published in Nature (London) (08.07.2021)
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Journal Article
Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses
Levy, Jonathan M., Yeh, Wei-Hsi, Pendse, Nachiket, Davis, Jessie R., Hennessey, Erin, Butcher, Rossano, Koblan, Luke W., Comander, Jason, Liu, Qin, Liu, David R.
Published in Nature biomedical engineering (01.01.2020)
Published in Nature biomedical engineering (01.01.2020)
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Journal Article
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
Komor, Alexis C, Zhao, Kevin T, Packer, Michael S, Gaudelli, Nicole M, Waterbury, Amanda L, Koblan, Luke W, Kim, Y Bill, Badran, Ahmed H, Liu, David R
Published in Science advances (01.08.2017)
Published in Science advances (01.08.2017)
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Journal Article
Deciphering cell states and genealogies of human haematopoiesis
Weng, Chen, Yu, Fulong, Yang, Dian, Poeschla, Michael, Liggett, L. Alexander, Jones, Matthew G., Qiu, Xiaojie, Wahlster, Lara, Caulier, Alexis, Hussmann, Jeffrey A., Schnell, Alexandra, Yost, Kathryn E., Koblan, Luke W., Martin-Rufino, Jorge D., Min, Joseph, Hammond, Alessandro, Ssozi, Daniel, Bueno, Raphael, Mallidi, Hari, Kreso, Antonia, Escabi, Javier, Rideout, William M., Jacks, Tyler, Hormoz, Sahand, van Galen, Peter, Weissman, Jonathan S., Sankaran, Vijay G.
Published in Nature (London) (14.03.2024)
Published in Nature (London) (14.03.2024)
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Journal Article
Adenine base editing in an adult mouse model of tyrosinaemia
Song, Chun-Qing, Jiang, Tingting, Richter, Michelle, Rhym, Luke H., Koblan, Luke W., Zafra, Maria Paz, Schatoff, Emma M., Doman, Jordan L., Cao, Yueying, Dow, Lukas E., Zhu, Lihua Julie, Anderson, Daniel G, Liu, David R., Yin, Hao, Xue, Wen
Published in Nature biomedical engineering (01.01.2020)
Published in Nature biomedical engineering (01.01.2020)
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Journal Article
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
Koblan, Luke W, Doman, Jordan L, Wilson, Christopher, Levy, Jonathan M, Tay, Tristan, Newby, Gregory A, Maianti, Juan Pablo, Raguram, Aditya, Liu, David R
Published in Nature biotechnology (01.10.2018)
Published in Nature biotechnology (01.10.2018)
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Journal Article
Base editor treats progeria in mice
Koblan, Luke W, Erdos, Michael R, Gordon, Leslie B, Collins, Francis S, Brown, Jonathan D, Liu, David R
Published in Nature (London) (18.06.2021)
Published in Nature (London) (18.06.2021)
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Journal Article
Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning
Koblan, Luke W., Arbab, Mandana, Shen, Max W., Hussmann, Jeffrey A., Anzalone, Andrew V., Doman, Jordan L., Newby, Gregory A., Yang, Dian, Mok, Beverly, Replogle, Joseph M., Xu, Albert, Sisley, Tyler A., Weissman, Jonathan S., Adamson, Britt, Liu, David R.
Published in Nature biotechnology (01.11.2023)
Published in Nature biotechnology (01.11.2023)
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Journal Article
In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice
Koblan, Luke W., Erdos, Michael R., Wilson, Christopher, Cabral, Wayne A., Levy, Jonathan M., Xiong, Zheng-Mei, Tavarez, Urraca L., Davison, Lindsay M., Gete, Yantenew G., Mao, Xiaojing, Newby, Gregory A., Doherty, Sean P., Narisu, Narisu, Sheng, Quanhu, Krilow, Chad, Lin, Charles Y., Gordon, Leslie B., Cao, Kan, Collins, Francis S., Brown, Jonathan D., Liu, David R.
Published in Nature (London) (28.01.2021)
Published in Nature (London) (28.01.2021)
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