Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL
Lai, Ashton C., Toure, Momar, Hellerschmied, Doris, Salami, Jemilat, Jaime-Figueroa, Saul, Ko, Eunhwa, Hines, John, Crews, Craig M.
Published in Angewandte Chemie International Edition (11.01.2016)
Published in Angewandte Chemie International Edition (11.01.2016)
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Journal Article
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
Huang, Hai-Tsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L., Doctor, Zainab M., Buckley, Dennis L., Cho, Joong-Heui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D., Li, Ying, Treon, Steven P., Fischer, Eric S., Bradner, James E., Tan, Li, Gray, Nathanael S.
Published in Cell chemical biology (18.01.2018)
Published in Cell chemical biology (18.01.2018)
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Journal Article
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors
Brahimi, Fouad, Ko, Eunhwa, Malakhov, Andrey, Burgess, Kevin, Saragovi, H Uri
Published in PloS one (06.03.2014)
Published in PloS one (06.03.2014)
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Journal Article
FRTX-02, a selective and potent inhibitor of DYRK1A, modulates inflammatory pathways in mouse models of psoriasis and atopic dermatitis
Kim, Soochan, Ko, Eunhwa, Choi, Hwan Geun, Kim, Daekwon, Luchi, Monica, Khor, Bernard, Kim, Sunghwan
Published in Journal of translational autoimmunity (Online) (01.01.2023)
Published in Journal of translational autoimmunity (Online) (01.01.2023)
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Journal Article
The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD
Lee, Ju-Young, Nam, Jin Han, Nam, Youngpyo, Nam, Hye Yeon, Yoon, Gwangho, Ko, Eunhwa, Kim, Sang-Bum, Bautista, Mahealani R, Capule, Christina C, Koyanagi, Takaoki, Leriche, Geoffray, Choi, Hwan Geun, Yang, Jerry, Kim, Jeongyeon, Hoe, Hyang-Sook
Published in Journal of neuroinflammation (11.10.2018)
Published in Journal of neuroinflammation (11.10.2018)
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Journal Article
Universal Peptidomimetics
Ko, Eunhwa, Liu, Jing, Perez, Lisa M, Lu, Genliang, Schaefer, Amber, Burgess, Kevin
Published in Journal of the American Chemical Society (26.01.2011)
Published in Journal of the American Chemical Society (26.01.2011)
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Journal Article
Catalytic in vivo protein knockdown by small-molecule PROTACs
Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M
Published in Nature chemical biology (01.08.2015)
Published in Nature chemical biology (01.08.2015)
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Journal Article
X‑ray Crystal Structure-Guided Design and Optimization of 7H‑Pyrrolo[2,3‑d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor
Lee, Younho, Kim, Hyunkyung, Kim, Haelee, Cho, Ha Yeon, Jee, Jun-Goo, Seo, Kyung-Ah, Son, Jung Beom, Ko, Eunhwa, Choi, Hwan Geun, Kim, Nam Doo, Kim, Ikyon
Published in Journal of medicinal chemistry (27.05.2021)
Published in Journal of medicinal chemistry (27.05.2021)
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Journal Article
Abstract P067: VRN10s, a series of HER2 inhibitors to overcome NRG-mediated drug resistance and acquired-drug resistant HER2 mutations
Park, Chan Mi, Yoo, Jihye, Son, Mingyeong, Jung, Hong-ryul, Park, Jin-Hee, Son, Jeongbum, Ko, Eunhwa, Kim, Sunghwan
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor
Lee, Younho, Kim, Hyunkyung, Kim, Haelee, Cho, Ha Yeon, Jee, Jun-Goo, Seo, Kyung-Ah, Son, Jung Beom, Ko, Eunhwa, Choi, Hwan Geun, Kim, Nam Doo, Kim, Ikyon
Published in Journal of medicinal chemistry (27.05.2021)
Published in Journal of medicinal chemistry (27.05.2021)
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Journal Article
Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors
Park, Hye-Kyung, Jeong, Hanbin, Ko, Eunhwa, Lee, Geumwoo, Lee, Ji-Eun, Lee, Sang Kwang, Lee, An-Jung, Im, Jin Young, Hu, Sung, Kim, Seong Heon, Lee, Ji Hoon, Lee, Changwook, Kang, Soosung, Kang, Byoung Heon
Published in Journal of medicinal chemistry (14.09.2017)
Published in Journal of medicinal chemistry (14.09.2017)
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Journal Article
Abstract P2-13-15: VRN101396, a brain-permeable HER2 inhibitor, shows the anti-tumor activity in preclinical HER2-positive cancer models
Jung, Hong-ryul, Kim, Sunghwan, Yoo, Jihye, Park, Chan mi, Lee, Somi, Lee, Hyoju, Lee, Youngyi, Park, Jinhee, Seo, Kyungah, Seo, Dong-Hyuk, Ko, Eunhwa, Son, Jung Beom, Kim, Deakwon, Choi, Hwan Geun, Kim, Nam Doo
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Journal Article
Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics
Raghuraman, Arjun, Ko, Eunhwa, Perez, Lisa M, Ioerger, Thomas R, Burgess, Kevin
Published in Journal of the American Chemical Society (17.08.2011)
Published in Journal of the American Chemical Society (17.08.2011)
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Journal Article
Abstract LB139: VRN10, Discovery of Potent Irreversible HER2 Kinase Inhibitors with Intracranial Activity
Kim, Hwan, Lee, Younho, Park, Jinhee, Lee, Youngyi, Choi, Jieun, Yoo, Jihye, Park, Chanmi, Lee, Somi, Ko, Eunhwa, Son, Jung Beom, Choi, Hwan Geun, Kim, Nam Doo, Kim, Daekwon, Kim, Sunghwan
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage
Bae, Yun-Hee, Joo, Hyejin, Bae, Jinhyun, Hyeon, Seung Jae, Her, Song, Ko, Eunhwa, Choi, Hwan Geun, Ryu, Hoon, Hur, Eun-Mi, Bu, Youngmin, Lee, Byoung Dae
Published in Cell death & disease (12.11.2018)
Published in Cell death & disease (12.11.2018)
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Journal Article
Exploring Key Orientations at Protein–Protein Interfaces with Small Molecule Probes
Ko, Eunhwa, Raghuraman, Arjun, Perez, Lisa M, Ioerger, Thomas R, Burgess, Kevin
Published in Journal of the American Chemical Society (09.01.2013)
Published in Journal of the American Chemical Society (09.01.2013)
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Journal Article
Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS)
Xin, Dongyue, Ko, Eunhwa, Perez, Lisa M, Ioerger, Thomas R, Burgess, Kevin
Published in Organic & biomolecular chemistry (28.11.2013)
Published in Organic & biomolecular chemistry (28.11.2013)
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Journal Article
Small Molecule Ligands for Active Targeting of TrkC-Expressing Tumor Cells
Ko, Eunhwa, Kamkaew, Anyanee, Burgess, Kevin
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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