Crystal structure of Leptospira LSS_01692 reveals a dimeric structure and induces inflammatory responses through Toll-like receptor 2-dependent NF-κB and MAPK signal transduction pathways
Hsu, Shen-Hsing, Wu, Che-Ting, Sun, Yuh-Ju, Chang, Ming-Yang, Li, Chien, Ko, Yi-Ching, Chou, Li-Fang, Yang, Chih-Wei
Published in The FEBS journal (01.09.2023)
Published in The FEBS journal (01.09.2023)
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Journal Article
The AMPK agonist AICAR inhibits TGF-β1 induced activation of kidney myofibroblasts
Chen, Kuan-Hsing, Hsu, Hsiang-Hao, Lee, Cheng-Chia, Yen, Tzu-Hai, Ko, Yi-Ching, Yang, Chih-Wei, Hung, Cheng-Chieh
Published in PloS one (04.09.2014)
Published in PloS one (04.09.2014)
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Journal Article
Peptidoglycan mediates Leptospira outer membrane protein Loa22 to toll-like receptor 2 for inflammatory interaction: a novel innate immune recognition
Hsu, Shen-Hsing, Chang, Ming-Yang, Lin, Shih-Ming, Ko, Yi-Ching, Chou, Li-Feng, Tian, Ya-Chung, Hung, Cheng-Chieh, Yang, Chih-Wei
Published in Scientific reports (13.01.2021)
Published in Scientific reports (13.01.2021)
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Journal Article
Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence
Yang, Huang-Yu, Hung, Cheng-Chieh, Liu, Su-Hsun, Guo, Yi-Gen, Chen, Yung-Chang, Ko, Yi-Ching, Huang, Chiung-Tseng, Chou, Li-Fang, Tian, Ya-Chung, Chang, Ming-Yang, Hsu, Hsiang-Hao, Lin, Ming-Yen, Hwang, Shang-Jyh, Yang, Chih-Wei
Published in PLoS neglected tropical diseases (09.10.2015)
Published in PLoS neglected tropical diseases (09.10.2015)
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Journal Article
Active Components of Leptospira Outer Membrane Protein LipL32 to Toll-Like Receptor 2
Hsu, Shen-Hsing, Hung, Cheng-Chieh, Chang, Ming-Yang, Ko, Yi-Ching, Yang, Huang-Yu, Hsu, Hsiang-Hao, Tian, Ya-Chung, Chou, Li-Fang, Pan, Rong-Long, Tseng, Fan-Gang, Yang, Chih-Wei
Published in Scientific reports (21.08.2017)
Published in Scientific reports (21.08.2017)
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Journal Article
Injection of hybrid 3D spheroids composed of podocytes, mesenchymal stem cells, and vascular endothelial cells into the renal cortex improves kidney function and replenishes glomerular podocytes
Yang, Wen‐Yu, Chen, Li‐Chi, Jhuang, Ya‐Ting, Lin, Yu‐Jie, Hung, Pei‐Yu, Ko, Yi‐Ching, Tsai, Meng‐Yu, Lee, Yun‐Wei, Hsu, Li‐Wen, Yeh, Chih‐Kuang, Hsu, Hsiang‐Hao, Huang, Chieh‐Cheng
Published in Bioengineering & translational medicine (01.05.2021)
Published in Bioengineering & translational medicine (01.05.2021)
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Journal Article
Implication of the IL-10-Expression Signature in the Pathogenicity of Leptospira -Infected Macrophages
Chou, Li-Fang, Chen, Ting-Wen, Yang, Huang-Yu, Tian, Ya-Chung, Chang, Ming-Yang, Hung, Cheng-Chieh, Lai, Chih-Ho, Hsu, Shen-Hsing, Tsai, Chung-Ying, Ko, Yi-Ching, Lian, Jang-Hau, Yang, Chih-Wei
Published in Microbiology spectrum (01.06.2022)
Published in Microbiology spectrum (01.06.2022)
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Journal Article
A Microfluidic Platform for Investigating Transmembrane Pressure-Induced Glomerular Leakage
Chen, Ting-Hsuan, Chen, Jie-Sheng, Ko, Yi-Ching, Chen, Jyun-Wei, Chu, Hsueh-Yao, Lu, Chih-Shuan, Chu, Chiao-Wen, Hsu, Hsiang-Hao, Tseng, Fan-Gang
Published in Micromachines (Basel) (10.05.2018)
Published in Micromachines (Basel) (10.05.2018)
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Journal Article
Potential impact on kidney infection: a whole-genome analysis of Leptospira santarosai serovar Shermani
Chou, Li-Fang, Chen, Ting-Wen, Ko, Yi-Ching, Pan, Ming-Jeng, Tian, Ya-Chung, Chiu, Cheng-Hsun, Tang, Petrus, Hung, Cheng-Chieh, Yang, Chih-Wei
Published in Emerging microbes & infections (01.11.2014)
Published in Emerging microbes & infections (01.11.2014)
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Journal Article
LipL41, a hemin binding protein from Leptospira santarosai serovar Shermani
Lin, Ming-Hsing, Chang, Yuan-Chih, Hsiao, Chwan-Deng, Huang, Shih-Hsun, Wang, Min-Shi, Ko, Yi-Ching, Yang, Chih-Wei, Sun, Yuh-Ju
Published in PloS one (12.12.2013)
Published in PloS one (12.12.2013)
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Journal Article
Noscapine alleviates unilateral ureteral obstruction-induced inflammation and fibrosis by regulating the TGFβ1/Smads signaling pathways
Hung, Cheng-Chieh, Chen, Kuan-Hsing, Hsu, Hsiang-Hao, Chang, Ming-Yang, Ko, Yi-Ching, Yang, Huang-Yu, Yang, Chih-Wei
Published in Biochimica et biophysica acta. Molecular cell research (01.01.2024)
Published in Biochimica et biophysica acta. Molecular cell research (01.01.2024)
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Journal Article
Blocking pathogenic Leptospira invasion with aptamer molecules targeting outer membrane LipL32 protein
Hsu, Shen-Hsing, Yang, Huang-Yu, Chang, Chia-Chen, Tsai, Shou-Kuan, Li, Chien, Chang, Ming-Yang, Ko, Yi-Ching, Chou, Li-Fang, Tsai, Chung-Ying, Tian, Ya-Chung, Yang, Chih-Wei
Published in Microbes and infection (01.05.2024)
Published in Microbes and infection (01.05.2024)
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Journal Article
Transcriptomic signatures of exacerbated progression in leptospirosis subclinical chronic kidney disease with secondary nephrotoxic injury
Chou, Li-Fang, Chen, Ting-Wen, Yang, Huang-Yu, Tian, Ya-Chung, Chang, Ming-Yang, Hung, Cheng-Chieh, Hsu, Shen-Hsing, Tsai, Chung-Ying, Ko, Yi-Ching, Yang, Chih-Wei
Published in American journal of physiology. Renal physiology (01.05.2021)
Published in American journal of physiology. Renal physiology (01.05.2021)
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Journal Article
Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury
Chou, Li-Fang, Huang, Chih-Wei, Yang, Huang-Yu, Tian, Ya-Chung, Chang, Ming-Yang, Hung, Cheng-Chieh, Chen, Kuan-Hsing, Hsu, Shen-Hsing, Tsai, Chung-Ying, Ko, Yi-Ching, Chen, Ting-Wen, Yang, Chih-Wei
Published in Genomics (San Diego, Calif.) (01.05.2023)
Published in Genomics (San Diego, Calif.) (01.05.2023)
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Journal Article
Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology
Premarathne, Shakila Sudarshani, Gamage, Chandika, Chandrajith, Rohana, Ratnatunge, Neelakanthi Vajira, Wijetunge, Sulochana, Wazil, Abdul, Chou, Li-Fang, Ko, Yi-Ching, Huang, Chiung-Tseng, Yang, Huang-Yu, Fonseka, Amanda, Sonnadara, Thamalu, Herath, Dulanjali, Hewavitharane, Pasan, Yang, Chih-Wei, Nanayakkara, Nishantha
Published in Nephron (2015) (01.08.2023)
Published in Nephron (2015) (01.08.2023)
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Journal Article
Murine Renal Transcriptome Profiles Upon Leptospiral Infection: Implications for Chronic Kidney Diseases
Chou, Li-Fang, Chen, Ting-Wen, Yang, Huang-Yu, Chang, Ming-Yang, Hsu, Shen-Hsing, Tsai, Chung-Ying, Ko, Yi-Ching, Huang, Chiung-Tseng, Tian, Ya-Chung, Hung, Cheng-Chieh, Yang, Chih-Wei
Published in The Journal of infectious diseases (22.09.2018)
Published in The Journal of infectious diseases (22.09.2018)
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Journal Article
Inhibition of spleen tyrosine kinase (syk) suppresses renal fibrosis through anti-inflammatory effects and down regulation of the MAPK-p38 pathway
Chen, Kuan-Hsing, Hsu, Hsiang-Hao, Yang, Huang-Yu, Tian, Ya-Chung, Ko, Yi-Ching, Yang, Chih-Wei, Hung, Cheng-Chieh
Published in The international journal of biochemistry & cell biology (01.05.2016)
Published in The international journal of biochemistry & cell biology (01.05.2016)
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Journal Article
Enhanced early immune response of leptospiral outer membrane protein LipL32 stimulated by narrow band mid-infrared exposure
Hong, Chung-Hung, Tang, Ming-Ru, Hsu, Shen-Hsing, Yang, Ching-Hsu, Tseng, Chi-Shin, Ko, Yi-Ching, Guo, Che-Shao, Yang, Chih-Wei, Lee, Si-Chen
Published in Journal of photochemistry and photobiology. B, Biology (01.09.2019)
Published in Journal of photochemistry and photobiology. B, Biology (01.09.2019)
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