Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Singh, Brijesh K, Chothani, Sonia P, Ng, Benjamin, Lim, Wei Wen, Zhou, Jin, Tripathi, Madhulika, Ko, Nicole S J, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Wang, Mao, Lio, Pei Min, Yen, Paul M, Schafer, Sebastian, Cook, Stuart A, Widjaja, Anissa A
Published in Nature communications (04.01.2021)
Published in Nature communications (04.01.2021)
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Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
Ng, Benjamin, Dong, Jinrui, D'Agostino, Giuseppe, Viswanathan, Sivakumar, Widjaja, Anissa A, Lim, Wei-Wen, Ko, Nicole S J, Tan, Jessie, Chothani, Sonia P, Huang, Benjamin, Xie, Chen, Pua, Chee Jian, Chacko, Ann-Marie, Guimarães-Camboa, Nuno, Evans, Sylvia M, Byrne, Adam J, Maher, Toby M, Liang, Jiurong, Jiang, Dianhua, Noble, Paul W, Schafer, Sebastian, Cook, Stuart A
Published in Science translational medicine (25.09.2019)
Published in Science translational medicine (25.09.2019)
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Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models
Lim, Wei-Wen, Corden, Ben, Ng, Benjamin, Vanezis, Konstantinos, D'Agostino, Giuseppe, Widjaja, Anissa A, Song, Wei-Hua, Xie, Chen, Su, Liping, Kwek, Xiu-Yi, Tee, Nicole G Z, Dong, Jinrui, Ko, Nicole S J, Wang, Mao, Pua, Chee Jian, Jamal, Muhammad H, Soh, Beeyong, Viswanathan, Sivakumar, Schafer, Sebastian, Cook, Stuart A
Published in Scientific reports (20.10.2020)
Published in Scientific reports (20.10.2020)
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Journal Article
Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease
Ng, Benjamin, Dong, Jinrui, Viswanathan, Sivakumar, Widjaja, Anissa A., Paleja, Bhairav S., Adami, Eleonora, Ko, Nicole S. J., Wang, Mao, Lim, Stella, Tan, Jessie, Chothani, Sonia P., Albani, Salvatore, Schafer, Sebastian, Cook, Stuart A.
Published in The FASEB journal (01.09.2020)
Published in The FASEB journal (01.09.2020)
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Journal Article
Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Lim, Wei-Wen, Ng, Benjamin, Widjaja, Anissa, Xie, Chen, Su, Liping, Ko, Nicole, Lim, Sze-Yun, Kwek, Xiu-Yi, Lim, Stella, Cook, Stuart Alexander, Schafer, Sebastian
Published in PloS one (09.01.2020)
Published in PloS one (09.01.2020)
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Journal Article
Therapeutic Targeting of Interleukin-11 Signalling Reduces Pressure Overload–Induced Cardiac Fibrosis in Mice
Corden, Ben, Lim, Wei-Wen, Song, Weihua, Chen, Xie, Ko, Nicole S. J., Su, Liping, Tee, Nicole G. Z., Adami, Eleonora, Schafer, Sebastian, Cook, Stuart A.
Published in Journal of cardiovascular translational research (01.04.2021)
Published in Journal of cardiovascular translational research (01.04.2021)
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Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo
Zhou, Jin, Ng, Benjamin, Ko, Nicole S J, Fiedler, Lorna R, Khin, Ester, Lim, Andrea, Sahib, Norliza E, Wu, Yajun, Chothani, Sonia P, Schafer, Sebastian, Bay, Boon-Huat, Sinha, Rohit A, Cook, Stuart A, Yen, Paul M
Published in Human molecular genetics (15.06.2019)
Published in Human molecular genetics (15.06.2019)
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Journal Article
Wars2 is a determinant of angiogenesis
Wang, Mao, Sips, Patrick, Khin, Ester, Rotival, Maxime, Sun, Ximing, Ahmed, Rizwan, Widjaja, Anissa Anindya, Schafer, Sebastian, Yusoff, Permeen, Choksi, Pervinder Kaur, Ko, Nicole Shi Jie, Singh, Manvendra K, Epstein, David, Guan, Yuguang, Houštěk, Josef, Mracek, Tomas, Nuskova, Hana, Mikell, Brittney, Tan, Jessie, Pesce, Francesco, Kolar, Frantisek, Bottolo, Leonardo, Mancini, Massimiliano, Hubner, Norbert, Pravenec, Michal, Petretto, Enrico, MacRae, Calum, Cook, Stuart A
Published in Nature communications (08.07.2016)
Published in Nature communications (08.07.2016)
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Journal Article
IL-11 is a crucial determinant of cardiovascular fibrosis
Schafer, Sebastian, Viswanathan, Sivakumar, Widjaja, Anissa A, Lim, Wei-Wen, Moreno-Moral, Aida, DeLaughter, Daniel M, Ng, Benjamin, Patone, Giannino, Chow, Kingsley, Khin, Ester, Tan, Jessie, Chothani, Sonia P, Ye, Lei, Rackham, Owen J L, Ko, Nicole S J, Sahib, Norliza E, Pua, Chee Jian, Zhen, Nicole T G, Xie, Chen, Wang, Mao, Maatz, Henrike, Lim, Shiqi, Saar, Kathrin, Blachut, Susanne, Petretto, Enrico, Schmidt, Sabine, Putoczki, Tracy, Guimarães-Camboa, Nuno, Wakimoto, Hiroko, van Heesch, Sebastiaan, Sigmundsson, Kristmundur, Lim, See L, Soon, Jia L, Chao, Victor T T, Chua, Yeow L, Tan, Teing E, Evans, Sylvia M, Loh, Yee J, Jamal, Muhammad H, Ong, Kim K, Chua, Kim C, Ong, Boon-Hean, Chakaramakkil, Mathew J, Seidman, Jonathan G, Seidman, Christine E, Hubner, Norbert, Sin, Kenny Y K, Cook, Stuart A
Published in Nature (London) (07.12.2017)
Published in Nature (London) (07.12.2017)
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Journal Article
Titin-truncating variants affect heart function in disease cohorts and the general population
Schafer, Sebastian, de Marvao, Antonio, Adami, Eleonora, Fiedler, Lorna R, Ng, Benjamin, Khin, Ester, Rackham, Owen J L, van Heesch, Sebastiaan, Pua, Chee J, Kui, Miao, Walsh, Roddy, Tayal, Upasana, Prasad, Sanjay K, Dawes, Timothy J W, Ko, Nicole S J, Sim, David, Chan, Laura L H, Chin, Calvin W L, Mazzarotto, Francesco, Barton, Paul J, Kreuchwig, Franziska, de Kleijn, Dominique P V, Totman, Teresa, Biffi, Carlo, Tee, Nicole, Rueckert, Daniel, Schneider, Valentin, Faber, Allison, Regitz-Zagrosek, Vera, Seidman, Jonathan G, Seidman, Christine E, Linke, Wolfgang A, Kovalik, Jean-Paul, O'Regan, Declan, Ware, James S, Hubner, Norbert, Cook, Stuart A
Published in Nature genetics (01.01.2017)
Published in Nature genetics (01.01.2017)
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Journal Article
Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation
Ng, Benjamin, Dong, Jinrui, Viswanathan, Sivakumar, Widjaja, Anissa A, Paleja, Bhairav S, Adami, Eleonora, Ko, Nicole Sj, Wang, Mao, Lim, Stella, Tan, Jessie, Chothani, Sonia P, Albani, Salvatore, Schafer, Sebastian, Cook, Stuart A
Published in bioRxiv (11.10.2019)
Published in bioRxiv (11.10.2019)
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Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis
Dong, Jinrui, Adami, Eleonora, Chothani, Sonia, Viswanathan, Sivakumar, Ng, Benjamin, Wei-Wen, Lim, Singh, Brijesh K, Zhou, Jin, Ko, Nicole, Shekeran, Shamini G, Tan, Jessie, Sze Yun Lim, Wang, Mao, Lio, Pei Min, Yen, Paul M, Schafer, Sebastian, Cook, Stuart A, Widjaja, Anissa Anindya
Published in bioRxiv (12.03.2020)
Published in bioRxiv (12.03.2020)
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Paper
IL-11 is a therapeutic target in idiopathic pulmonary fibrosis
Cook, Stuart, Ng, Benjamin, Dong, Jinrui, Viswanathan, Sivakumar, Dagostino, Giuseppe, Widjaja, Anissa, Wei-Wen, Lim, Ko, Nicole, Tan, Jessie, Chothani, Sonia, Huang, Benjamin, Xie, Chen, Chacko, Ann-Marie, Guimaraes-Camboa, Nuno, Evans, Sylvia, Byrne, Adam, Maher, Toby, Liang, Jiurong, Noble, Paul, Schafer, Sebastian
Published in bioRxiv (02.06.2018)
Published in bioRxiv (02.06.2018)
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