Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
Bogeska, Ruzhica, Mikecin, Ana-Matea, Kaschutnig, Paul, Fawaz, Malak, Büchler-Schäff, Marleen, Le, Duy, Ganuza, Miguel, Vollmer, Angelika, Paffenholz, Stella V., Asada, Noboru, Rodriguez-Correa, Esther, Frauhammer, Felix, Buettner, Florian, Ball, Melanie, Knoch, Julia, Stäble, Sina, Walter, Dagmar, Petri, Amelie, Carreño-Gonzalez, Martha J., Wagner, Vinona, Brors, Benedikt, Haas, Simon, Lipka, Daniel B., Essers, Marieke A.G., Weru, Vivienn, Holland-Letz, Tim, Mallm, Jan-Philipp, Rippe, Karsten, Krämer, Stephan, Schlesner, Matthias, McKinney Freeman, Shannon, Florian, Maria Carolina, King, Katherine Y., Frenette, Paul S., Rieger, Michael A., Milsom, Michael D.
Published in Cell stem cell (04.08.2022)
Published in Cell stem cell (04.08.2022)
Get full text
Journal Article
3010 – THE IMPACT OF AGING AND INFLAMMATORY STRESS ON GENOME STABILITY IN HEMATOPOIETIC STEM CELLS
Druce, Megan, Cagan, Alex, Bogeska, Ruzhica, Imbusch, Charles, Knoch, Julia, Martincorena, Inigo, Brors, Benedikt, Milsom, Michael
Published in Experimental hematology (01.08.2020)
Published in Experimental hematology (01.08.2020)
Get full text
Journal Article
3164 – APPARENT HEMATOPOIETIC STEM CELL LINEAGE BIASES ARE MEDIATED BY CELL EXTRINSIC FEEDBACK MECHANISMS
Correa, Esther Rodriguez, Grünschläger, Florian, Nizharadze, Tamar, Anstee, Natasha, Ball, Melanie, Jayarajan, Jeyan, Knoch, Julia, Druce, Megan, Ghezzi, Ian, Fotopoulou, Foteini, Büchler-Schäff, Marleen, Lux, Susanne, Aurich, Theo, Hübschmann, Daniel, Höfer, Thomas, Haas, Simon, Milsom, Michael
Published in Experimental hematology (2023)
Published in Experimental hematology (2023)
Get full text
Journal Article
3169 – SERIAL SINGLE CELL TRANSPLANTATIONS DEMONSTRATE A DEFINED HIERARCHY OF HSC SUBTYPES CORRELATING WITH LOSS OF RECONSTITUTION POTENTIAL
Rodriguez-Correa, Esther, Anstee, Natasha, Nizharadze, Tamar, Li, Congxin, Ball, Melanie, Knoch, Julia, Jayarajan, Jeyan, Druce, Megan, Fotopoulou, Foteini, Ghezzi, Ian, Büchler-Schäff, Marleen, Lux, Susanne, Shah, Dhyani, Aurich, Theo, Höfer, Thomas, Milsom, Michael
Published in Experimental hematology (2022)
Published in Experimental hematology (2022)
Get full text
Journal Article
No Evidence for Hematopoietic Stem Cell Self-Renewal in-Vivo Following Inflammatory Challenge
Bogeska, Ruzhica, Kaschutnig, Paul, Paffenholz, Stella V, Knoch, Julia, Mallm, Jan-Philipp, Fawaz, Malak, Buettner, Florian, Walter, Dagmar, Frauhammer, Felix, Holland-Letz, Tim, Asada, Noboru, Mikecin Drazic, Ana-Matea, Buechler-Schaff, Marleen, Correno-Gonzalez, Martha, Ball, Melanie, Staeble, Sina, Gräsel, Julius, Haas, Simon, Lipka, Daniel B., Rippe, Karsten, Brors, Benedikt, Frenette, Paul S., Rieger, Michael A., Essers, Marieke A.G., Milsom, Michael D.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
Get full text
Journal Article
Deconvolution of Hematopoietic Commitment Decisions By Genome-Wide Analysis of Progressive DNA Methylation Changes
Staeble, Sina, Kraemer, Stephen, Langstein, Jens, Bogeska, Ruzhica, Hartmann, Mark, Schoenung, Maximilian, Czeh, Melinda, Knoch, Julia, Anstee, Natasha, Haas, Simon, Mahmoud, Abdelrahman, Graesel, Julius, Huebschmann, Daniel, Feuerbach, Lars, Dieter, Weichenhan, Brors, Benedikt, Rippe, Karsten, Mallm, Jan-Philipp, Rosenbauer, Frank, Plass, Christoph, Schlesner, Matthias, Milsom, Michael D., Lipka, Daniel B.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
Get full text
Journal Article
3037 – COMBINED SINGLE-CELL DNA METHYLOME AND TRANSCRIPTOME ANALYSIS IDENTIFIES MOLECULAR STATES OF EARLY LINEAGE COMMITMENT
Stäble, Sina, Krämer, Stephen, Hartmann, Mark, Schönung, Maximilian, Langstein, Jens, Bogeska, Ruzhica, Czeh, Melinda, Knoch, Julia, Anstee, Natasha, Haas, Simon, Mahmoud, Abdelrahman, Imbusch, Charles, Gräsel, Julius, Weichenhan, Dieter Weichenhan, Feuerbach, Lars, Brors, Benedikt, Rippe, Karsten, Mallm, Jan-Philipp, Rosenbauer, Frank, Fröhling, Stefan, Plass, Christoph, Schlesner, Matthias, Milsom, Michael, Lipka, Daniel
Published in Experimental hematology (01.08.2020)
Published in Experimental hematology (01.08.2020)
Get full text
Journal Article
HSCs completely fail to regenerate following inflammatory challenge, leading to aged hematopoiesis
Bogeska, Ruzhica, Kaschutnig, Paul, Paffenholz, Stella, Knoch, Julia, Walter, Dagmar, Mallm, Jan-Philipp, Frauhammer, Felix, Blaszkiewicz, Sandra, Holland-Letz, Tim, Asada, Noboru, Gräsel, Julius, Stäble, Sina, Prendergast, Áine, Haas, Simon, Lipka, Daniel, Rippe, Karsten, Brors, Benedikt, Frenette, Paul, Essers, Marieke, Milsom, Michael
Published in Experimental hematology (01.09.2017)
Published in Experimental hematology (01.09.2017)
Get full text
Journal Article
Hematopoietic stem cells fail to regenerate following inflammatory challenge
Bogeska, Ruzhica, Kaschutnig, Paul, Fawaz, Malak, Ana-Matea Mikecin, Buechler-Schaeff, Marleen, Paffenholz, Stella, Asada, Noboru, Frauhammer, Felix, Buettner, Florian, Ball, Melanie, Knoch, Julia, Staeble, Sina, Walter, Dagmar, Petri, Amelie, Carreno-Gonzalez, Martha J, Wagner, Vinona, Brors, Benedikt, Haas, Simon, Lipka, Daniel B, Essers, Marieke Ag, Holland-Letz, Tim, Jan-Philipp Mallm, Rippe, Karsten, Frenette, Paul S, Rieger, Michael A, Milsom, Michael D
Published in bioRxiv (03.08.2020)
Published in bioRxiv (03.08.2020)
Get full text
Paper