Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML
Oellerich, Thomas, Schneider, Constanze, Thomas, Dominique, Knecht, Kirsten M., Buzovetsky, Olga, Kaderali, Lars, Schliemann, Christoph, Bohnenberger, Hanibal, Angenendt, Linus, Hartmann, Wolfgang, Wardelmann, Eva, Rothenburger, Tamara, Mohr, Sebastian, Scheich, Sebastian, Comoglio, Federico, Wilke, Anne, Ströbel, Philipp, Serve, Hubert, Michaelis, Martin, Ferreirós, Nerea, Geisslinger, Gerd, Xiong, Yong, Keppler, Oliver T., Cinatl, Jindrich
Published in Nature communications (02.08.2019)
Published in Nature communications (02.08.2019)
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Journal Article
The SAM domain of mouse SAMHD1 is critical for its activation and regulation
Buzovetsky, Olga, Tang, Chenxiang, Knecht, Kirsten M., Antonucci, Jenna M., Wu, Li, Ji, Xiaoyun, Xiong, Yong
Published in Nature communications (29.01.2018)
Published in Nature communications (29.01.2018)
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Journal Article
SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways
Chen, Shuliang, Bonifati, Serena, Qin, Zhihua, St. Gelais, Corine, Kodigepalli, Karthik M., Barrett, Bradley S., Kim, Sun Hee, Antonucci, Jenna M., Ladner, Katherine J., Buzovetsky, Olga, Knecht, Kirsten M., Xiong, Yong, Yount, Jacob S., Guttridge, Denis C., Santiago, Mario L., Wu, Li
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2018)
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Journal Article
A Noncanonical Basic Motif of Epstein-Barr Virus ZEBRA Protein Facilitates Recognition of Methylated DNA, High-Affinity DNA Binding, and Lytic Activation
Weber, Erin, Buzovetsky, Olga, Heston, Lee, Yu, Kuan-Ping, Knecht, Kirsten M, El-Guindy, Ayman, Miller, George, Xiong, Yong
Published in Journal of virology (15.07.2019)
Published in Journal of virology (15.07.2019)
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Journal Article
Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi–Goutières syndrome SAMHD1 dNTPase ortholog
Maehigashi, Tatsuya, Lim, Christopher, Wade, Lydia R., Bowen, Nicole E., Knecht, Kirsten M., Alvarez, Natalie N., Kelly, William G., Schinazi, Raymond F., Kim, Dong-Hyun, Xiong, Yong, Kim, Baek
Published in The Journal of biological chemistry (01.09.2023)
Published in The Journal of biological chemistry (01.09.2023)
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Journal Article
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
Knecht, Kirsten M., Buzovetsky, Olga, Schneider, Constanze, Thomas, Dominique, Srikanth, Vishok, Kaderali, Lars, Tofoleanu, Florentina, Reiss, Krystle, Ferreirós, Nerea, Geisslinger, Gerd, Batista, Victor S., Ji, Xiaoyun, Cinatl, Jindrich, Keppler, Oliver T., Xiong, Yong
Published in Proceedings of the National Academy of Sciences - PNAS (23.10.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (23.10.2018)
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Journal Article
SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4 + T Cells
Antonucci, Jenna M, Kim, Sun Hee, St Gelais, Corine, Bonifati, Serena, Li, Tai-Wei, Buzovetsky, Olga, Knecht, Kirsten M, Duchon, Alice A, Xiong, Yong, Musier-Forsyth, Karin, Wu, Li
Published in Journal of virology (01.08.2018)
Published in Journal of virology (01.08.2018)
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Journal Article
Maedi–visna virus Vif protein uses motifs distinct from HIV-1 Vif to bind zinc and the cofactor required for A3 degradation
Knecht, Kirsten M., Hu, Yingxia, Rubene, Diana, Cook, Matthew, Ziegler, Samantha J., Jónsson, Stefán R., Xiong, Yong
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Journal Article
A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation
St Gelais, Corine, Kim, Sun Hee, Maksimova, Victoria V, Buzovetsky, Olga, Knecht, Kirsten M, Shepard, Caitlin, Kim, Baek, Xiong, Yong, Wu, Li
Published in Journal of virology (15.03.2018)
Published in Journal of virology (15.03.2018)
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Journal Article
A threonine zipper that mediates protein–protein interactions: Structure and prediction
Oi, Curran, Treado, John D., Levine, Zachary A., Lim, Christopher S., Knecht, Kirsten M., Xiong, Yong, O'Hern, Corey S., Regan, Lynne
Published in Protein science (01.11.2018)
Published in Protein science (01.11.2018)
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Journal Article
Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif
Hu, Yingxia, Gudnadóttir, Ragna B, Knecht, Kirsten M, Arizaga, Fidel, Jónsson, Stefán R, Xiong, Yong
Published in Science advances (13.01.2023)
Published in Science advances (13.01.2023)
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Journal Article
SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways
Chen, Shuliang, Bonifati, Serena, Qin, Zhihua, St Gelais, Corine, Kodigepalli, Karthik M, Barrett, Bradley S, Kim, Sun Hee, Antonucci, Jenna M, Ladner, Katherine J, Buzovetsky, Olga, Knecht, Kirsten M, Xiong, Yong, Yount, Jacob S, Guttridge, Denis C, Santiago, Mario L, Wu, Li
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2018)
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Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2018)
Journal Article
Maedi-visna virus Vif protein uses motifs distinct from HIV-1 Vif to bind zinc and cofactor required for A3 degradation
Knecht, Kirsten M, Hu, Yingxia, Rubene, Diana, Cook, Matthew, Ziegler, Samantha J, Jónsson, Stefán R, Xiong, Yong
Published in The Journal of biological chemistry (09.11.2020)
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Published in The Journal of biological chemistry (09.11.2020)
Journal Article
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
Knecht, Kirsten M, Buzovetsky, Olga, Schneider, Constanze, Thomas, Dominique, Vishok Srikanth, Tofoleanu, Florentina, Reiss, Krystle, Nerea Ferreir s, Geisslinger, Gerd, Batista, Victor S, Ji, Xiaoyun, Cinatl, Jindrich, Keppler, Oliver T, Xiong, Yong
Published in bioRxiv (06.04.2018)
Published in bioRxiv (06.04.2018)
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