Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression
Bailey-Elkin, Ben A., Knaap, Robert C.M., Johnson, Garrett G., Dalebout, Tim J., Ninaber, Dennis K., van Kasteren, Puck B., Bredenbeek, Peter J., Snijder, Eric J., Kikkert, Marjolein, Mark, Brian L.
Published in The Journal of biological chemistry (12.12.2014)
Published in The Journal of biological chemistry (12.12.2014)
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Structure and Function of Viral Deubiquitinating Enzymes
Bailey-Elkin, Ben A., Knaap, Robert C.M., Kikkert, Marjolein, Mark, Brian L.
Published in Journal of molecular biology (10.11.2017)
Published in Journal of molecular biology (10.11.2017)
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Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses
Rabouw, Huib H, Langereis, Martijn A, Knaap, Robert C M, Dalebout, Tim J, Canton, Javier, Sola, Isabel, Enjuanes, Luis, Bredenbeek, Peter J, Kikkert, Marjolein, de Groot, Raoul J, van Kuppeveld, Frank J M
Published in PLoS pathogens (01.10.2016)
Published in PLoS pathogens (01.10.2016)
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Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis
Bailey-Elkin, Ben A, Knaap, Robert C M, De Silva, Anuradha, Boekhoud, Ilse M, Mous, Sandra, van Vught, Niek, Khajehpour, Mazdak, van den Born, Erwin, Kikkert, Marjolein, Mark, Brian L
Published in PLoS pathogens (14.12.2023)
Published in PLoS pathogens (14.12.2023)
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Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase
Myeni, Sebenzile K., Bredenbeek, Peter J., Knaap, Robert C. M., Dalebout, Tim J., Morales, Shessy Torres, Sidorov, Igor A., Linger, Marissa E., Oreshkova, Nadia, van Zanen-Gerhardt, Sophie, Zander, Serge A. L., Enjuanes, Luis, Sola, Isabel, Snijder, Eric J., Kikkert, Marjolein
Published in Nature communications (28.02.2023)
Published in Nature communications (28.02.2023)
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Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants
Zhang, Wei, Bailey-Elkin, Ben A, Knaap, Robert C M, Khare, Baldeep, Dalebout, Tim J, Johnson, Garrett G, van Kasteren, Puck B, McLeish, Nigel J, Gu, Jun, He, Wenguang, Kikkert, Marjolein, Mark, Brian L, Sidhu, Sachdev S
Published in PLoS pathogens (01.05.2017)
Published in PLoS pathogens (01.05.2017)
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Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo
van Huizen, Mariska, Bloeme-Ter Horst, Jonna R, de Gruyter, Heidi L M, Geurink, Paul P, van der Heden van Noort, Gerbrand J, Knaap, Robert C M, Nelemans, Tessa, Ogando, Natacha S, Leijs, Anouk A, Urakova, Nadya, Mark, Brian L, Snijder, Eric J, Myeni, Sebenzile K, Kikkert, Marjolein
Published in PLoS pathogens (01.03.2024)
Published in PLoS pathogens (01.03.2024)
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In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2
van Kasteren, Puck B., Knaap, Robert C.M., van den Elzen, Paul, Snijder, Eric J., Balasuriya, Udeni B.R., van den Born, Erwin, Kikkert, Marjolein
Published in Veterinary microbiology (09.07.2015)
Published in Veterinary microbiology (09.07.2015)
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