Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results
Rovite, Vita, Wolff-Sagi, Yael, Zaharenko, Linda, Nikitina-Zake, Liene, Grens, Elmars, Klovins, Janis
Published in Journal of epidemiology (05.08.2018)
Published in Journal of epidemiology (05.08.2018)
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Journal Article
Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
Zake, Darta Maija, Kurlovics, Janis, Zaharenko, Linda, Komasilovs, Vitalijs, Klovins, Janis, Stalidzans, Egils
Published in PloS one (07.04.2021)
Published in PloS one (07.04.2021)
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Journal Article
Evaluating the Efficacy of Type 2 Diabetes Polygenic Risk Scores in an Independent European Population
Brīvība, Monta, Atava, Ivanna, Pečulis, Raitis, Elbere, Ilze, Ansone, Laura, Rozenberga, Maija, Silamiķelis, Ivars, Kloviņš, Jānis
Published in International journal of molecular sciences (01.01.2024)
Published in International journal of molecular sciences (01.01.2024)
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Journal Article
Hydroxycarboxylic Acid Receptor Ligands Modulate Proinflammatory Cytokine Expression in Human Macrophages and Adipocytes without Affecting Adipose Differentiation
Mandrika, Ilona, Tilgase, Andra, Petrovska, Ramona, Klovins, Janis
Published in Biological & pharmaceutical bulletin (01.10.2018)
Published in Biological & pharmaceutical bulletin (01.10.2018)
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Journal Article
Association of metformin administration with gut microbiome dysbiosis in healthy volunteers
Elbere, Ilze, Kalnina, Ineta, Silamikelis, Ivars, Konrade, Ilze, Zaharenko, Linda, Sekace, Kristine, Radovica-Spalvina, Ilze, Fridmanis, Davids, Gudra, Dita, Pirags, Valdis, Klovins, Janis
Published in PloS one (27.09.2018)
Published in PloS one (27.09.2018)
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Journal Article
Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes
Silamiķele, Laila, Silamiķelis, Ivars, Ustinova, Monta, Kalniņa, Zane, Elbere, Ilze, Petrovska, Ramona, Kalniņa, Ineta, Kloviņš, Jānis
Published in Frontiers in endocrinology (Lausanne) (19.03.2021)
Published in Frontiers in endocrinology (Lausanne) (19.03.2021)
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Journal Article
Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation
Ansone, Laura, Rovite, Vita, Brīvība, Monta, Jagare, Lauma, Pelcmane, Līva, Borisova, Daniella, Thews, Anne, Leiminger, Roland, Kloviņš, Jānis
Published in International journal of molecular sciences (01.02.2024)
Published in International journal of molecular sciences (01.02.2024)
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Journal Article
ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?
Fridmanis, Davids, Roga, Ance, Klovins, Janis
Published in Frontiers in endocrinology (Lausanne) (06.02.2017)
Published in Frontiers in endocrinology (Lausanne) (06.02.2017)
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Journal Article
Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients
Elbere, Ilze, Silamikelis, Ivars, Dindune, Ilze Izabella, Kalnina, Ineta, Ustinova, Monta, Zaharenko, Linda, Silamikele, Laila, Rovite, Vita, Gudra, Dita, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis
Published in PloS one (30.10.2020)
Published in PloS one (30.10.2020)
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Journal Article
Single-Cell RNA Sequencing Reveals Alterations in Patient Immune Cells with Pulmonary Long COVID-19 Complications
Vaivode, Kristīne, Saksis, Rihards, Litvina, Helēna Daiga, Niedra, Helvijs, Spriņģe, Marta Līva, Krūmiņa, Una, Kloviņš, Jānis, Rovite, Vita
Published in Current Issues in Molecular Biology (01.01.2024)
Published in Current Issues in Molecular Biology (01.01.2024)
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Journal Article
Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance
Brīvība, Monta, Silamiķele, Laila, Kalniņa, Ineta, Silamiķelis, Ivars, Birzniece, Līga, Ansone, Laura, Jagare, Lauma, Elbere, Ilze, Kloviņš, Jānis
Published in Frontiers in endocrinology (Lausanne) (19.09.2023)
Published in Frontiers in endocrinology (Lausanne) (19.09.2023)
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Journal Article
Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations
Tambets, Kristiina, Yunusbayev, Bayazit, Hudjashov, Georgi, Ilumäe, Anne-Mai, Rootsi, Siiri, Honkola, Terhi, Vesakoski, Outi, Atkinson, Quentin, Skoglund, Pontus, Kushniarevich, Alena, Litvinov, Sergey, Reidla, Maere, Metspalu, Ene, Saag, Lehti, Rantanen, Timo, Karmin, Monika, Parik, Jüri, Zhadanov, Sergey I, Gubina, Marina, Damba, Larisa D, Bermisheva, Marina, Reisberg, Tuuli, Dibirova, Khadizhat, Evseeva, Irina, Nelis, Mari, Klovins, Janis, Metspalu, Andres, Esko, Tõnu, Balanovsky, Oleg, Balanovska, Elena, Khusnutdinova, Elza K, Osipova, Ludmila P, Voevoda, Mikhail, Villems, Richard, Kivisild, Toomas, Metspalu, Mait
Published in Genome Biology (21.09.2018)
Published in Genome Biology (21.09.2018)
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Journal Article
Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis
Ansone, Laura, Briviba, Monta, Silamikelis, Ivars, Terentjeva, Anna, Perkons, Ingus, Birzniece, Liga, Rovite, Vita, Rozentale, Baiba, Viksna, Ludmila, Kolesova, Oksana, Klavins, Kristaps, Klovins, Janis
Published in Microbiology spectrum (22.12.2021)
Published in Microbiology spectrum (22.12.2021)
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Journal Article
Exploring disease-specific metabolite signatures in hereditary angioedema patients
Kanepa, Adine, Fan, Jingzhi, Rots, Dmitrijs, Vaska, Annija, Ansone, Laura, Briviba, Monta, Klovins, Janis, Kurjane, Natalja, Klavins, Kristaps
Published in Frontiers in immunology (25.04.2024)
Published in Frontiers in immunology (25.04.2024)
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Journal Article
Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
Ustinova, Monta, Silamikelis, Ivars, Kalnina, Ineta, Ansone, Laura, Rovite, Vita, Elbere, Ilze, Radovica-Spalvina, Ilze, Fridmanis, Davids, Aladyeva, Jekaterina, Konrade, Ilze, Pirags, Valdis, Klovins, Janis
Published in PloS one (08.11.2019)
Published in PloS one (08.11.2019)
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Journal Article
Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors
Peculis, Raitis, Rovite, Vita, Megnis, Kaspars, Balcere, Inga, Breiksa, Austra, Nazarovs, Jurijs, Stukens, Janis, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis
Published in PloS one (26.08.2022)
Published in PloS one (26.08.2022)
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Journal Article
Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response
Ustinova, Monta, Ansone, Laura, Silamikelis, Ivars, Rovite, Vita, Elbere, Ilze, Silamikele, Laila, Kalnina, Ineta, Fridmanis, Davids, Sokolovska, Jelizaveta, Konrade, Ilze, Pirags, Valdis, Klovins, Janis
Published in PloS one (11.08.2020)
Published in PloS one (11.08.2020)
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Journal Article
Changes in the type 2 diabetes gut mycobiome associate with metformin treatment across populations
Van Syoc, Emily, Nixon, Michelle Pistner, Silverman, Justin D, Luo, Yuhong, Gonzalez, Frank J, Elbere, Ilze, Klovins, Janis, Patterson, Andrew D, Rogers, Connie J, Ganda, Erika
Published in mBio (12.06.2024)
Published in mBio (12.06.2024)
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Journal Article
Genetic structure of Europeans: a view from the North-East
Nelis, Mari, Esko, Tõnu, Mägi, Reedik, Zimprich, Fritz, Zimprich, Alexander, Toncheva, Draga, Karachanak, Sena, Piskácková, Tereza, Balascák, Ivan, Peltonen, Leena, Jakkula, Eveliina, Rehnström, Karola, Lathrop, Mark, Heath, Simon, Galan, Pilar, Schreiber, Stefan, Meitinger, Thomas, Pfeufer, Arne, Wichmann, H-Erich, Melegh, Béla, Polgár, Noémi, Toniolo, Daniela, Gasparini, Paolo, D'Adamo, Pio, Klovins, Janis, Nikitina-Zake, Liene, Kucinskas, Vaidutis, Kasnauskiene, Jūrate, Lubinski, Jan, Debniak, Tadeusz, Limborska, Svetlana, Khrunin, Andrey, Estivill, Xavier, Rabionet, Raquel, Marsal, Sara, Julià, Antonio, Antonarakis, Stylianos E, Deutsch, Samuel, Borel, Christelle, Attar, Homa, Gagnebin, Maryline, Macek, Milan, Krawczak, Michael, Remm, Maido, Metspalu, Andres
Published in PloS one (08.05.2009)
Published in PloS one (08.05.2009)
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Journal Article
Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia
Ustinova, Monta, Peculis, Raitis, Rescenko, Raimonds, Rovite, Vita, Zaharenko, Linda, Elbere, Ilze, Silamikele, Laila, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis
Published in BMC medical genomics (11.01.2021)
Published in BMC medical genomics (11.01.2021)
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Journal Article