Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial
Rozeman, Elisa A, Menzies, Alexander M, van Akkooi, Alexander C J, Adhikari, Chandra, Bierman, Carolien, van de Wiel, Bart A, Scolyer, Richard A, Krijgsman, Oscar, Sikorska, Karolina, Eriksson, Hanna, Broeks, Annegien, van Thienen, Johannes V, Guminski, Alexander D, Acosta, Alex Torres, ter Meulen, Sylvia, Koenen, Anne Miek, Bosch, Linda J W, Shannon, Kerwin, Pronk, Loes M, Gonzalez, Maria, Ch'ng, Sydney, Grijpink-Ongering, Lindsay G, Stretch, Jonathan, Heijmink, Stijn, van Tinteren, Harm, Haanen, John B A G, Nieweg, Omgo E, Klop, Willem M C, Zuur, Charlotte L, Saw, Robyn P M, van Houdt, Winan J, Peeper, Daniel S, Spillane, Andrew J, Hansson, Johan, Schumacher, Ton N, Long, Georgina V, Blank, Christian U
Published in The lancet oncology (01.07.2019)
Published in The lancet oncology (01.07.2019)
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Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial
Reijers, Irene L. M., Menzies, Alexander M., van Akkooi, Alexander C. J., Versluis, Judith M., van den Heuvel, Noëlle M. J., Saw, Robyn P. M., Pennington, Thomas E., Kapiteijn, Ellen, van der Veldt, Astrid A. M., Suijkerbuijk, Karijn P. M., Hospers, Geke A. P., Rozeman, Elisa A., Klop, Willem M. C., van Houdt, Winan J., Sikorska, Karolina, van der Hage, Jos A., Grünhagen, Dirk J., Wouters, Michel W., Witkamp, Arjen J., Zuur, Charlotte L., Lijnsvelt, Judith M., Torres Acosta, Alejandro, Grijpink-Ongering, Lindsay G., Gonzalez, Maria, Jóźwiak, Katarzyna, Bierman, Carolien, Shannon, Kerwin F., Ch’ng, Sydney, Colebatch, Andrew J., Spillane, Andrew J., Haanen, John B. A. G., Rawson, Robert V., van de Wiel, Bart A., van de Poll-Franse, Lonneke V., Scolyer, Richard A., Boekhout, Annelies H., Long, Georgina V., Blank, Christian U.
Published in Nature medicine (01.06.2022)
Published in Nature medicine (01.06.2022)
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IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma
Reijers, Irene L M, Rao, Disha, Versluis, Judith M, Menzies, Alexander M, Dimitriadis, Petros, Wouters, Michel W, Spillane, Andrew J, Klop, Willem M C, Broeks, Annegien, Bosch, Linda J W, Lopez-Yurda, Marta, van Houdt, Winan J, Rawson, Robert V, Grijpink-Ongering, Lindsay G, Gonzalez, Maria, Cornelissen, Sten, Bouwman, Jasper, Sanders, Joyce, Plasmeijer, Elsemieke, Elshot, Yannick S, Scolyer, Richard A, van de Wiel, Bart A, Peeper, Daniel S, van Akkooi, Alexander C J, Long, Georgina V, Blank, Christian U
Published in The Journal of experimental medicine (01.05.2023)
Published in The Journal of experimental medicine (01.05.2023)
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Neoadjuvant T-VEC + nivolumab combination therapy for resectable early metastatic (stage IIIB/C/D-IV M1a) melanoma with injectable disease: NIVEC trial
Zijlker, Lisanne P., van Houdt, Winan J., Stahlie, Emma H.A., Franke, Viola, Rohaan, Maartje W., Delatzakis, Antonios, Zuur, Charlotte, Klop, Willem M.C., van de Wiel, Bart A., Kuijpers, Anke, de Boer, Elianne, van Thienen, Johannes V., Haanen, John B. A. G., Van Akkooi, Alexander Christopher Jonathan
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC)
van Akkooi, Alexander C. J., Hieken, Tina J., Burton, Elizabeth M., Ariyan, Charlotte, Ascierto, Paolo A., Asero, Salvatore V. M. A., Blank, Christian U., Block, Matthew S., Boland, Genevieve M., Caraco, Corrado, Chng, Sydney, Davidson, B. Scott, Duprat Neto, Joao Pedreira, Faries, Mark B., Gershenwald, Jeffrey E., Grunhagen, Dirk J., Gyorki, David E., Han, Dale, Hayes, Andrew J., van Houdt, Winan J., Karakousis, Giorgos C., Klop, Willem M. C., Long, Georgina V., Lowe, Michael C., Menzies, Alexander M., Olofsson Bagge, Roger, Pennington, Thomas E., Rutkowski, Piotr, Saw, Robyn P. M., Scolyer, Richard A., Shannon, Kerwin F., Sondak, Vernon K., Tawbi, Hussein, Testori, Alessandro A. E., Tetzlaff, Mike T., Thompson, John F., Zager, Jonathan S., Zuur, Charlotte L., Wargo, Jennifer A., Spillane, Andrew J., Ross, Merrick I.
Published in Annals of surgical oncology (01.06.2022)
Published in Annals of surgical oncology (01.06.2022)
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Challenges in sentinel node (SN) pathology in the era of adjuvant treatment: The risk of over and undertreatment stress the need for expert pathology review
Franke, Viola, Madu, Max Fullah, Bierman, Carolien, Klop, Willem M.C., van Houdt, Winan J., Wouters, Michel W.J.M., Van De Wiel, Bart A., Van Akkooi, Alexander Christopher Jonathan
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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T-VEC for stage IIIB-IVM1a melanoma achieves high rates of complete and durable responses and is associated with tumor load: a clinical prediction model
Stahlie, Emma H. A., Franke, Viola, Zuur, Charlotte L., Klop, Willem M. C., van der Hiel, Bernies, Van de Wiel, Bart A., Wouters, Michel W. J. M., Schrage, Yvonne M., van Houdt, Winan J., van Akkooi, Alexander C. J.
Published in Cancer Immunology, Immunotherapy (01.08.2021)
Published in Cancer Immunology, Immunotherapy (01.08.2021)
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Rate of complete and durable responses of intralesional therapy with talimogene laherparepvec for stage IIIB-IVM1a melanoma and association with tumor load
Stahlie, Emma H.A., Franke, Viola, Zuur, Charlotte L., Klop, Willem M.C., Van Der Hiel, Bernies, Van De Wiel, Bart A., Wouters, Michel W.J.M., Schrage, Yvonne, van Houdt, Winan J., Van Akkooi, Alexander Christopher Jonathan
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Impact of personalized response-directed surgery and adjuvant therapy on survival after neoadjuvant immunotherapy in stage III melanoma: comparison of 3-year data from PRADO and OpACIN-neo
Reijers, Irene LM, Menzies, Alexander M, Lopez-Yurda, Marta, Versluis, Judith M, Rozeman, Elisa A, Saw, Robyn PM, van Houdt, Winan J, Kapiteijn, Ellen, van der Veldt, Astrid AM, Suijkerbuijk, Karijn PM, Eriksson, Hanna, Hospers, Geke AP, MC Klop, Willem, Acosta, Alejandro Torres, Grijpink-Ongering, Lindsay, Gonzalez, Maria, van der Wal, Anja, Al-Mamgani, Abrahim, Spillane, Andrew J, Scolyer, Richard A, van de Wiel, Bart A, van Akkooi, Alexander CJ, Long, Georgina V, Blank, Christian U
Published in European journal of cancer (1990) (19.11.2024)
Published in European journal of cancer (1990) (19.11.2024)
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The impact of response-directed surgery and adjuvant therapy on long-term survival after neoadjuvant ipilimumab plus nivolumab in stage III melanoma: Three-year data of PRADO and OpACIN-neo
Reijers, Irene L.M., Menzies, Alexander M., Versluis, Judith M., Saw, Robyn P.M., van Houdt, Winan J., Kapiteijn, Ellen, Van Der Veldt, Astrid Aplonia Maria, Suijkerbuijk, Karijn, Eriksson, Hanna, Hospers, Geke, Klop, Willem M.C., Lopez-Yurda, Marta I., Grijpink-Ongering, Lindsay G., Gonzalez, Maria, Spillane, Andrew John, Scolyer, Richard A., van de Wiel, Bart A., Van Akkooi, Alexander Christopher Jonathan, Long, Georgina V., Blank, Christian U.
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2023)
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2023)
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Conference Proceeding
External validation of the 8th Edition Melanoma Staging System of the American Joint Committee on Cancer (AJCC): Effect of adding EORTC sentinel node (SN) tumor burden criteria on prognostic accuracy in stage III
Madu, Max Fullah, Franke, Viola, Van De Wiel, Bart, Klop, Willem M.C., Józwiak, Katarzyna, Wouters, Michel W.J.M., Van Akkooi, Alexander Christopher Jonathan
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Single agent Talimogene Laherparepvec for stage IIIB-IVM1c melanoma patients: A systematic review and meta-analysis
Stahlie, Emma H.A., Mulder, Evalyn E.A.P., Reijers, Sophie, Balduzzi, Sara, Zuur, Charlotte L., Klop, Willem M.C., van der Hiel, Bernies, Van de Wiel, Bart A., Wouters, Michel W.J.M., Schrage, Yvonne M., van Houdt, Winan J., Grunhagen, Dirk J., van Akkooi, Alexander C.J.
Published in Critical reviews in oncology/hematology (01.07.2022)
Published in Critical reviews in oncology/hematology (01.07.2022)
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Health-related quality of life in stage III melanoma patients treated with neoadjuvant ipilimumab and nivolumab followed by index lymph node excision only, compared to therapeutic lymph node dissection: First results of the PRADO trial
Van den Heuvel, Noëlle Milena Jane, Reijers, Irene L.M., Rozeman, Elisa A., Versluis, Judith M., Józwiak, Katarzyna, Spillane, Andrew, Scolyer, Richard A., Pennington, Thomas, Saw, Robyn PM, Gonzalez, Maria, van Houdt, Winan J., Klop, Willem M.C., Wouters, Michel W.J.M., Menzies, Alexander M., Van Akkooi, Alexander Christopher Jonathan, van de Poll-Franse, Lonneke V, Long, Georgina V., Blank, Christian U., Boekhout, Annelies H.
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Talimogene laherparepvec monotherapy for head and neck melanoma patients
Franke, Viola, Stahlie, Emma H A, Klop, Willem M C, Zuur, Charlotte L, Berger, Danique M S, van der Hiel, Bernies, van de Wiel, Bart A, Wouters, Michel W J M, van Houdt, Winan J, van Akkooi, Alexander C J
Published in Melanoma research (01.02.2023)
Published in Melanoma research (01.02.2023)
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Immediate completion lymph node dissection in stage IIIA melanoma does not provide significant additional staging information beyond EORTC SN tumour burden criteria
Madu, Max F., Franke, Viola, Bruin, Maarten M., Berger, Danique M.S., Bierman, Carolien, Jóźwiak, Katarzyna, Klop, Willem M.C., Wouters, Michel W.J.M., van Akkooi, Alexander C.J., Van de Wiel, Bart A.
Published in European journal of cancer (1990) (01.12.2017)
Published in European journal of cancer (1990) (01.12.2017)
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Journal Article
External validation of the American Joint Committee on Cancer 8th edition melanoma staging system: who needs adjuvant treatment?
Madu, Max F, Franke, Viola, Van de Wiel, Bart A, Klop, Willem M C, Jóźwiak, Katarzyna, van Houdt, Winan J, Wouters, Michel W J M, van Akkooi, Alexander C J
Published in Melanoma research (01.04.2020)
Published in Melanoma research (01.04.2020)
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Twenty-four months RFS and updated toxicity data from OpACIN-neo: A study to identify the optimal dosing schedule of neoadjuvant ipilimumab (IPI) and nivolumab (NIVO) in stage III melanoma
Rozeman, Elisa A., Reijers, Irene L.M., Hoefsmit, Esmée P, Sikorska, Karolina, Krijgsman, Oscar, Van De Wiel, Bart A., Dimitriadis, Petros, Eriksson, Hanna, Gonzalez, Maria, Grijpink-Ongering, Lindsay G, Kerkhoven, Ron M., Broeks, Annegien, Klop, Willem M.C., Spillane, Andrew, Saw, Robyn PM, Van Akkooi, Alexander Christopher Jonathan, Scolyer, Richard A., Menzies, Alexander M., Long, Georgina V., Blank, Christian U.
Published in JOURNAL OF CLINICAL ONCOLOGY (20.05.2020)
Published in JOURNAL OF CLINICAL ONCOLOGY (20.05.2020)
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Journal Article
Conference Proceeding
Challenges in sentinel node pathology in the era of adjuvant treatment
Franke, Viola, Madu, Max F., Bierman, Carolien, Klop, Willem M. C., Houdt, Winan J., Wouters, Michel W. J. M., Wiel, Bart A., Akkooi, Alexander C. J.
Published in Journal of surgical oncology (01.10.2020)
Published in Journal of surgical oncology (01.10.2020)
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Positron emission tomography/computed tomography evaluation of oncolytic virus therapy efficacy in melanoma
Franke, Viola, van der Hiel, Bernies, van de Wiel, Bart A., Klop, Willem M.C., ter Meulen, Sylvia, van Akkooi, Alexander C.J.
Published in European journal of cancer (1990) (01.02.2018)
Published in European journal of cancer (1990) (01.02.2018)
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