Preclinical activity of nanoliposomal irinotecan is governed by tumor deposition and intratumor prodrug conversion
Kalra, Ashish V, Kim, Jaeyeon, Klinz, Stephan G, Paz, Nancy, Cain, Jason, Drummond, Daryl C, Nielsen, Ulrik B, Fitzgerald, Jonathan B
Published in Cancer research (Chicago, Ill.) (01.12.2014)
Published in Cancer research (Chicago, Ill.) (01.12.2014)
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Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study
Ramanathan, Ramesh K, Korn, Ronald L, Raghunand, Natarajan, Sachdev, Jasgit C, Newbold, Ronald G, Jameson, Gayle, Fetterly, Gerald J, Prey, Joshua, Klinz, Stephan G, Kim, Jaeyeon, Cain, Jason, Hendriks, Bart S, Drummond, Daryl C, Bayever, Eliel, Fitzgerald, Jonathan B
Published in Clinical cancer research (15.07.2017)
Published in Clinical cancer research (15.07.2017)
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Journal Article
Augmenting Experimental Gastric Cancer Activity of Irinotecan through Liposomal Formulation and Antiangiogenic Combination Therapy
Awasthi, Niranjan, Schwarz, Margaret A, Zhang, Changhua, Klinz, Stephan G, Meyer-Losic, Florence, Beaufils, Benjamin, Thiagalingam, Arunthathi, Schwarz, Roderich E
Published in Molecular cancer therapeutics (05.07.2022)
Published in Molecular cancer therapeutics (05.07.2022)
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Journal Article
Impact of tumor HER2/ERBB2 expression level on HER2-targeted liposomal doxorubicin-mediated drug delivery: multiple low-affinity interactions lead to a threshold effect
Hendriks, Bart S, Klinz, Stephan G, Reynolds, Joseph G, Espelin, Christopher W, Gaddy, Daniel F, Wickham, Thomas J
Published in Molecular cancer therapeutics (01.09.2013)
Published in Molecular cancer therapeutics (01.09.2013)
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HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity
Reynolds, Joseph G., Geretti, Elena, Hendriks, Bart S., Lee, Helen, Leonard, Shannon C., Klinz, Stephan G., Noble, Charles O., Lücker, Petra B., Zandstra, Peter W., Drummond, Daryl C., Olivier, Kenneth J., Nielsen, Ulrik B., Niyikiza, Clet, Agresta, Samuel V., Wickham, Thomas J.
Published in Toxicology and applied pharmacology (01.07.2012)
Published in Toxicology and applied pharmacology (01.07.2012)
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Journal Article
Extended topoisomerase 1 inhibition through liposomal irinotecan results in improved efficacy over topotecan and irinotecan in models of small-cell lung cancer
Leonard, Shannon C, Lee, Helen, Gaddy, Daniel F, Klinz, Stephan G, Paz, Nancy, Kalra, Ashish V, Drummond, Daryl C, Chan, Daniel C, Bunn, Paul A, Fitzgerald, Jonathan B, Hendriks, Bart S
Published in Anti-cancer drugs (01.11.2017)
Published in Anti-cancer drugs (01.11.2017)
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Journal Article
Correction to: Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia
Ventura, Manuela, Bernards, Nicholas, De Souza, Raquel, Fricke, Inga B., Hendriks, Bart S., Fitzgerald, Jonathan B., Lee, Helen, Klinz, Stephan G., Zheng, Jinzi
Published in Molecular imaging and biology (01.04.2021)
Published in Molecular imaging and biology (01.04.2021)
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Journal Article
Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia
Ventura, Manuela, Bernards, Nicholas, De Souza, Raquel, Fricke, Inga B., Hendriks, Bart S., Fitzgerald, Jonathan B., Lee, Helen, Klinz, Stephan G., Zheng, Jinzi
Published in Molecular imaging and biology (01.06.2020)
Published in Molecular imaging and biology (01.06.2020)
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Journal Article
Pretherapy Ferumoxytol-enhanced MRI to Predict Response to Liposomal Irinotecan in Metastatic Breast Cancer
Ravi, Harshan, Arias-Lorza, Andres M, Costello, James R, Han, Hyo Sook, Jeong, Daniel K, Klinz, Stephan G, Sachdev, Jasgit C, Korn, Ronald L, Raghunand, Natarajan
Published in Radiology. Imaging cancer (01.03.2023)
Published in Radiology. Imaging cancer (01.03.2023)
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An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
Goi, Takanori, Shipitsin, Michail, Lu, Zhimin, Foster, David A., Klinz, Stephan G., Feig, Larry A.
Published in The EMBO journal (15.02.2000)
Published in The EMBO journal (15.02.2000)
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Journal Article
Differentiation of liposomal irinotecan from dose-dense non-liposomal irinotecan in patient-derived pancreatic cancer xenograft tumor models
Barbier, Sandrine, Lezmi, Stephane, Beaufils, Benjamin, Lortie, Adreanne, Hillairet de Boisferon, Marc, Chaumeron, Sophie, Espirito, Anne, Klinz, Stephan G, Thiagalingam, Arunthathi, Meyer-Losic, Florence
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
DNA damage with liposomal irinotecan (nal-IRI) in pancreatic cancer xenografts: Multimodal analysis of deposition characteristics
Klinz, Stephan G, Leonard, Shannon C., Paz, Nancy, Gaddy, Daniel, Lee, Helen, Hendricks, Bart, Fitzgerald, Jonathan B
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article
Deposition characteristics and resulting DNA damage patterns of liposomal irinotecan (nal-IRI) in pancreatic cancer xenografts
Leonard, Shannon C., Paz, Nancy, Klinz, Stephan G, Gaddy, Daniel, Lee, Helen, Hendriks, Bart S, Fitzgerald, Jonathan B
Published in Journal of clinical oncology (01.02.2018)
Published in Journal of clinical oncology (01.02.2018)
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Journal Article
CANCER TREATMENTS WITH RADIATION AND IMMUNOCYTOKINES
KALLEN KARL JOSEF, KLINZ STEPHAN G, GNAD VOGT ULRIKE, WICKHAM THOMAS, HOLDEN SYLVIA A
Year of Publication 27.07.2011
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Year of Publication 27.07.2011
Patent
Influence of liposomal irinotecan (nal-IRI) and non-liposomal irinotecan, alone and in combination, on tumor growth and angiogenesis in colorectal cancer (CRC) models
Larsen, Annette K, Trindade, Cristiano, Bouygues, Anaïs, Louadj, Lila K, Thouroude, Sandrine K, Klinz, Stephan G, Kalra, Ashish, Henriques, João, Chibaudel, Benoist, De Gramont, Aimery, Escargueil, Alexandre E, Mesange, Paul
Published in Journal of clinical oncology (01.02.2018)
Published in Journal of clinical oncology (01.02.2018)
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Journal Article
Preclinical antitumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) and utilization as a foundation of front-line pancreatic cancer regimens
Gaddy, Daniel F., Lee, Helen, Paz, Nancy, Leonard, Shannon C., Kalra, Ashish, Straubinger, Ninfa L., Straubinger, Robert M, Gillard, Bryan M., Moser, Michael T., Foster, Barbara A., Drummond, Daryl C., Klinz, Stephan G., Hendriks, Bart, Fitzgerald, Jonathan B.
Published in Journal of clinical oncology (01.02.2017)
Published in Journal of clinical oncology (01.02.2017)
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Journal Article
Abstract 4830: Preclinical anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) + 5-FU + oxaliplatin in pancreatic cancer
Gaddy, Daniel F., Lee, Helen, Paz, Nancy, Leonard, Shannon C., Kalra, Ashish, Straubinger, Ninfa L., Straubinger, Robert M., Gillard, Bryan M., Moser, Michael T., Drummond, Daryl C., Klinz, Stephan G., Hendriks, Bart S., Fitzgerald, Jonathan B.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract P5-01-06: Characterization of metastatic breast cancer lesions with ferumoxytol MRI and treatment response to MM-398, nanoliposomal irinotecan (nal-IRI)
Sachdev, Jasgit C, Ramanathan, Ramesh K, Raghunand, Natarajan, Kim, Jaeyeon, Klinz, Stephan G, Bayever, Eliel, Fitzgerald, Jonathan B, Korn, Ronald L
Published in Cancer research (Chicago, Ill.) (01.05.2015)
Published in Cancer research (Chicago, Ill.) (01.05.2015)
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Journal Article
Abstract CT224: Pilot study in patients with advanced solid tumors to evaluate feasibility of ferumoxytol (FMX) as tumor imaging agent prior to MM-398, a nanoliposomal irinotecan (nal-IRI)
Ramanathan, Ramesh K., Korn, Ronald L., Sachdev, Jasgit C., Fetterly, Gerald J., Marceau, Katie, Marsh, Vickie, Neil, John M., Newbold, Ronald G., Raghunand, Natarajan, Prey, Joshua, Klinz, Stephan G., Bayever, Eliel, Fitzgerald, Jonathan B.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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