Preclinical activity of nanoliposomal irinotecan is governed by tumor deposition and intratumor prodrug conversion
Kalra, Ashish V, Kim, Jaeyeon, Klinz, Stephan G, Paz, Nancy, Cain, Jason, Drummond, Daryl C, Nielsen, Ulrik B, Fitzgerald, Jonathan B
Published in Cancer research (Chicago, Ill.) (01.12.2014)
Published in Cancer research (Chicago, Ill.) (01.12.2014)
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Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study
Ramanathan, Ramesh K, Korn, Ronald L, Raghunand, Natarajan, Sachdev, Jasgit C, Newbold, Ronald G, Jameson, Gayle, Fetterly, Gerald J, Prey, Joshua, Klinz, Stephan G, Kim, Jaeyeon, Cain, Jason, Hendriks, Bart S, Drummond, Daryl C, Bayever, Eliel, Fitzgerald, Jonathan B
Published in Clinical cancer research (15.07.2017)
Published in Clinical cancer research (15.07.2017)
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Journal Article
Augmenting Experimental Gastric Cancer Activity of Irinotecan through Liposomal Formulation and Antiangiogenic Combination Therapy
Awasthi, Niranjan, Schwarz, Margaret A, Zhang, Changhua, Klinz, Stephan G, Meyer-Losic, Florence, Beaufils, Benjamin, Thiagalingam, Arunthathi, Schwarz, Roderich E
Published in Molecular cancer therapeutics (05.07.2022)
Published in Molecular cancer therapeutics (05.07.2022)
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Journal Article
Antitumor effects of the multi-target tyrosine kinase inhibitor cabozantinib: a comprehensive review of the preclinical evidence
Santoni, Matteo, Iacovelli, Roberto, Colonna, Valentina, Klinz, Stephan, Mauri, Giorgio, Nuti, Marianna
Published in Expert review of anticancer therapy (02.09.2021)
Published in Expert review of anticancer therapy (02.09.2021)
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Journal Article
Impact of tumor HER2/ERBB2 expression level on HER2-targeted liposomal doxorubicin-mediated drug delivery: multiple low-affinity interactions lead to a threshold effect
Hendriks, Bart S, Klinz, Stephan G, Reynolds, Joseph G, Espelin, Christopher W, Gaddy, Daniel F, Wickham, Thomas J
Published in Molecular cancer therapeutics (01.09.2013)
Published in Molecular cancer therapeutics (01.09.2013)
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Journal Article
Extended topoisomerase 1 inhibition through liposomal irinotecan results in improved efficacy over topotecan and irinotecan in models of small-cell lung cancer
Leonard, Shannon C, Lee, Helen, Gaddy, Daniel F, Klinz, Stephan G, Paz, Nancy, Kalra, Ashish V, Drummond, Daryl C, Chan, Daniel C, Bunn, Paul A, Fitzgerald, Jonathan B, Hendriks, Bart S
Published in Anti-cancer drugs (01.11.2017)
Published in Anti-cancer drugs (01.11.2017)
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HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity
Reynolds, Joseph G., Geretti, Elena, Hendriks, Bart S., Lee, Helen, Leonard, Shannon C., Klinz, Stephan G., Noble, Charles O., Lücker, Petra B., Zandstra, Peter W., Drummond, Daryl C., Olivier, Kenneth J., Nielsen, Ulrik B., Niyikiza, Clet, Agresta, Samuel V., Wickham, Thomas J.
Published in Toxicology and applied pharmacology (01.07.2012)
Published in Toxicology and applied pharmacology (01.07.2012)
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Journal Article
Correction to: Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia
Ventura, Manuela, Bernards, Nicholas, De Souza, Raquel, Fricke, Inga B., Hendriks, Bart S., Fitzgerald, Jonathan B., Lee, Helen, Klinz, Stephan G., Zheng, Jinzi
Published in Molecular imaging and biology (01.04.2021)
Published in Molecular imaging and biology (01.04.2021)
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Journal Article
Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia
Ventura, Manuela, Bernards, Nicholas, De Souza, Raquel, Fricke, Inga B., Hendriks, Bart S., Fitzgerald, Jonathan B., Lee, Helen, Klinz, Stephan G., Zheng, Jinzi
Published in Molecular imaging and biology (01.06.2020)
Published in Molecular imaging and biology (01.06.2020)
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Journal Article
Pretherapy Ferumoxytol-enhanced MRI to Predict Response to Liposomal Irinotecan in Metastatic Breast Cancer
Ravi, Harshan, Arias-Lorza, Andres M, Costello, James R, Han, Hyo Sook, Jeong, Daniel K, Klinz, Stephan G, Sachdev, Jasgit C, Korn, Ronald L, Raghunand, Natarajan
Published in Radiology. Imaging cancer (01.03.2023)
Published in Radiology. Imaging cancer (01.03.2023)
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Journal Article
Liposomal Irinotecan Shows a Larger Therapeutic Index than Non-liposomal Irinotecan in Patient-Derived Xenograft Models of Pancreatic Cancer
Barbier, Sandrine, Beaufils, Benjamin, de Miguel, Ricardo, Reyre, Melissa, Le Meitour, Yannick, Lortie, Andreanne, de Boisferon, Marc Hillairet, Chaumeron, Sophie, Espirito, Anne, Fossati, Lina, Lagarde, Pauline, Klinz, Stephan, Thiagalingam, Arunthathi, Lezmi, Stéphane, Meyer-Losic, Florence
Published in Oncology and therapy (01.03.2023)
Published in Oncology and therapy (01.03.2023)
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Journal Article
An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
Goi, Takanori, Shipitsin, Michail, Lu, Zhimin, Foster, David A., Klinz, Stephan G., Feig, Larry A.
Published in The EMBO journal (15.02.2000)
Published in The EMBO journal (15.02.2000)
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Journal Article
Tyrosine kinase inhibitor cabozantinib impacts dendritic and natural killer cells immune response in C38 syngeneic tumor model
Divoux, Jordane, Rolland, Sylvie, Delille, Raphael, Levin, Clément, Martin, Vincent, Young, Pamela, Meyer‐Losic, Florence, Klinz, Stephan
Published in European journal of immunology (01.06.2023)
Published in European journal of immunology (01.06.2023)
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Journal Article
Abstract 553: Antitumor efficacy of a liposomal formulation of irinotecan in preclinical gastric cancer models: Augmenting its response by antiangiogenic agents
Awasthi, Niranjan, Schwarz, Margaret A., Zhang, Changhua, Klinz, Stephan, Meyer-Losic, Florence, Beaufils, Benjamin, Thiagalingam, Arunthathi, Schwarz, Roderich E.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Differentiation of liposomal irinotecan from dose-dense non-liposomal irinotecan in patient-derived pancreatic cancer xenograft tumor models
Barbier, Sandrine, Lezmi, Stephane, Beaufils, Benjamin, Lortie, Adreanne, Hillairet de Boisferon, Marc, Chaumeron, Sophie, Espirito, Anne, Klinz, Stephan G, Thiagalingam, Arunthathi, Meyer-Losic, Florence
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
Abstract 5151: Nanoliposomal irinotecan (nal-IRI, MM-398) has greater anti-tumor activity than topotecan and irinotecan in mouse models of small cell lung cancer
Leonard, Shannon C., Gaddy, Daniel, Lee, Helen, Klinz, Stephan, Fitzgerald, Jonathan, Hendriks, Bart
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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DNA damage with liposomal irinotecan (nal-IRI) in pancreatic cancer xenografts: Multimodal analysis of deposition characteristics
Klinz, Stephan G, Leonard, Shannon C., Paz, Nancy, Gaddy, Daniel, Lee, Helen, Hendricks, Bart, Fitzgerald, Jonathan B
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article
Deposition characteristics and resulting DNA damage patterns of liposomal irinotecan (nal-IRI) in pancreatic cancer xenografts
Leonard, Shannon C., Paz, Nancy, Klinz, Stephan G, Gaddy, Daniel, Lee, Helen, Hendriks, Bart S, Fitzgerald, Jonathan B
Published in Journal of clinical oncology (01.02.2018)
Published in Journal of clinical oncology (01.02.2018)
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