ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
Klim, Joseph R, Williams, Luis A, Limone, Francesco, Guerra San Juan, Irune, Davis-Dusenbery, Brandi N, Mordes, Daniel A, Burberry, Aaron, Steinbaugh, Michael J, Gamage, Kanchana K, Kirchner, Rory, Moccia, Rob, Cassel, Seth H, Chen, Kuchuan, Wainger, Brian J, Woolf, Clifford J, Eggan, Kevin
Published in Nature neuroscience (01.02.2019)
Published in Nature neuroscience (01.02.2019)
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Journal Article
Connecting TDP-43 Pathology with Neuropathy
Klim, Joseph R., Pintacuda, Greta, Nash, Leslie A., Guerra San Juan, Irune, Eggan, Kevin
Published in Trends in neurosciences (Regular ed.) (01.06.2021)
Published in Trends in neurosciences (Regular ed.) (01.06.2021)
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Journal Article
Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection
Wells, Michael F., Salick, Max R., Wiskow, Ole, Ho, Daniel J., Worringer, Kathleen A., Ihry, Robert J., Kommineni, Sravya, Bilican, Bilada, Klim, Joseph R., Hill, Ellen J., Kane, Liam T., Ye, Chaoyang, Kaykas, Ajamete, Eggan, Kevin
Published in Cell stem cell (01.12.2016)
Published in Cell stem cell (01.12.2016)
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Journal Article
A defined glycosaminoglycan-binding substratum for human pluripotent stem cells
Kiessling, Laura L, Klim, Joseph R, Li, Lingyin, Wrighton, Paul J, Piekarczyk, Marian S
Published in Nature methods (01.12.2010)
Published in Nature methods (01.12.2010)
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Journal Article
How to make spinal motor neurons
Davis-Dusenbery, Brandi N, Williams, Luis A, Klim, Joseph R, Eggan, Kevin
Published in Development (Cambridge) (01.02.2014)
Published in Development (Cambridge) (01.02.2014)
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Journal Article
Modeling ALS with motor neurons derived from human induced pluripotent stem cells
Sances, Samuel, Bruijn, Lucie I, Chandran, Siddharthan, Eggan, Kevin, Ho, Ritchie, Klim, Joseph R, Livesey, Matt R, Lowry, Emily, Macklis, Jeffrey D, Rushton, David, Sadegh, Cameron, Sareen, Dhruv, Wichterle, Hynek, Zhang, Su-Chun, Svendsen, Clive N
Published in Nature neuroscience (01.04.2016)
Published in Nature neuroscience (01.04.2016)
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Journal Article
Pluripotent stem cell strategies for rebuilding the human brain
Limone, Francesco, Klim, Joseph R, Mordes, Daniel A
Published in Frontiers in aging neuroscience (02.11.2022)
Published in Frontiers in aging neuroscience (02.11.2022)
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Journal Article
Loss of mouse Stmn2 function causes motor neuropathy
Guerra San Juan, Irune, Nash, Leslie A., Smith, Kevin S., Leyton-Jaimes, Marcel F., Qian, Menglu, Klim, Joseph R., Limone, Francesco, Dorr, Alexander B., Couto, Alexander, Pintacuda, Greta, Joseph, Brian J., Whisenant, D. Eric, Noble, Caroline, Melnik, Veronika, Potter, Deirdre, Holmes, Amie, Burberry, Aaron, Verhage, Matthijs, Eggan, Kevin
Published in Neuron (Cambridge, Mass.) (18.05.2022)
Published in Neuron (Cambridge, Mass.) (18.05.2022)
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Journal Article
Single Acetylation-mimetic Mutation in TDP-43 Nuclear Localization Signal Disrupts Importin α1/β Signaling
Ko, Ying-Hui, Lokareddy, Ravi K., Doll, Steven G., Yeggoni, Daniel P., Girdhar, Amandeep, Mawn, Ian, Klim, Joseph R., Rizvi, Noreen F., Meyers, Rachel, Gillilan, Richard E., Guo, Lin, Cingolani, Gino
Published in Journal of molecular biology (15.10.2024)
Published in Journal of molecular biology (15.10.2024)
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Journal Article
Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation
Huang, Xuan, Roet, Kasper C.D., Zhang, Liying, Brault, Amy, Berg, Allison P., Jefferson, Anne B., Klug-McLeod, Jackie, Leach, Karen L., Vincent, Fabien, Yang, Hongying, Coyle, Anthony J., Jones, Lyn H., Frost, Devlin, Wiskow, Ole, Chen, Kuchuan, Maeda, Rie, Grantham, Alyssa, Dornon, Mary K., Klim, Joseph R., Siekmann, Marco T., Zhao, Dongyi, Lee, Seungkyu, Eggan, Kevin, Woolf, Clifford J.
Published in Cell reports (Cambridge) (08.06.2021)
Published in Cell reports (Cambridge) (08.06.2021)
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Journal Article
Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins
Wrighton, Paul J., Klim, Joseph R., Hernandez, Brandon A., Koonce, Chad H., Kamp, Timothy J., Kiessling, Laura L.
Published in Proceedings of the National Academy of Sciences - PNAS (23.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (23.12.2014)
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Journal Article
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1
Tripathi, Pratibha, Rodriguez-Muela, Natalia, Klim, Joseph R., de Boer, A. Sophie, Agrawal, Sahil, Sandoe, Jackson, Lopes, Claudia S., Ogliari, Karolyn Sassi, Williams, Luis A., Shear, Matthew, Rubin, Lee L., Eggan, Kevin, Zhou, Qiao
Published in Stem cell reports (08.08.2017)
Published in Stem cell reports (08.08.2017)
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Journal Article
Loss of mouse Stmn2 function causes motor neuropathy
San Juan, Irune Guerra, Nash, Leslie A., Smith, Kevin S., Leyton-Jaimes, Marcel F., Qian, Menglu, Klim, Joseph R., Limone, Francesco, Dorr, Alexander B., Couto, Alexander, Pintacuda, Greta, Joseph, Brian J., Whisenant, D. Eric, Noble, Caroline, Melnik, Veronika, Potter, Deirdre, Holmes, Amie, Burberry, Aaron, Verhage, Matthijs, Eggan, Kevin
Published in Neuron (Cambridge, Mass.) (07.12.2022)
Published in Neuron (Cambridge, Mass.) (07.12.2022)
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Journal Article
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology
de Majo, Martina, Koontz, Mark, Marsan, Elise, Salinas, Nir, Ramsey, Arren, Kuo, Yien-Ming, Seo, Kyounghee, Li, Huinan, Dräger, Nina, Leng, Kun, Gonzales, Santiago L., Kurnellas, Michael, Miyaoka, Yuichiro, Klim, Joseph R., Kampmann, Martin, Ward, Michael E., Huang, Eric J., Ullian, Erik M.
Published in Stem cell reports (14.03.2023)
Published in Stem cell reports (14.03.2023)
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Journal Article
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients
Mordes, Daniel A, Prudencio, Mercedes, Goodman, Lindsey D, Klim, Joseph R, Moccia, Rob, Limone, Francesco, Pietilainen, Olli, Chowdhary, Kaitavjeet, Dickson, Dennis W, Rademakers, Rosa, Bonini, Nancy M, Petrucelli, Leonard, Eggan, Kevin
Published in Acta neuropathologica communications (04.07.2018)
Published in Acta neuropathologica communications (04.07.2018)
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Journal Article
Downregulation of the silent potassium channel Kv8.1 increases motor neuron vulnerability in amyotrophic lateral sclerosis
Huang, Xuan, Lee, Seungkyu, Chen, Kuchuan, Kawaguchi, Riki, Wiskow, Ole, Ghosh, Sulagna, Frost, Devlin, Perrault, Laura, Pandey, Roshan, Klim, Joseph R, Boivin, Bruno, Hermawan, Crystal, Livak, Kenneth J, Geschwind, Daniel H, Wainger, Brian J, Eggan, Kevin C, Bean, Bruce P, Woolf, Clifford J
Published in Brain communications (21.06.2024)
Published in Brain communications (21.06.2024)
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Journal Article
Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein
Farhan, Sali M K, Howrigan, Daniel P, Abbott, Liam E, Klim, Joseph R, Topp, Simon D, Byrnes, Andrea E, Churchhouse, Claire, Phatnani, Hemali, Smith, Bradley N, Rampersaud, Evadnie, Wu, Gang, Wuu, Joanne, Shatunov, Aleksey, Iacoangeli, Alfredo, Khleifat, Ahmad Al, Mordes, Daniel A, Ghosh, Sulagna, Eggan, Kevin, Rademakers, Rosa, McCauley, Jacob L, Schüle, Rebecca, Züchner, Stephan, Benatar, Michael, Taylor, J Paul, Nalls, Michael, Gotkine, Marc, Shaw, Pamela J, Morrison, Karen E, Al-Chalabi, Ammar, Traynor, Bryan, Shaw, Christopher E, Goldstein, David B, Harms, Matthew B, Daly, Mark J, Neale, Benjamin M
Published in Nature neuroscience (01.02.2020)
Published in Nature neuroscience (01.02.2020)
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