Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
Kliewer, A., Schmiedel, F., Sianati, S., Bailey, A., Bateman, J. T., Levitt, E. S., Williams, J. T., Christie, M. J., Schulz, S.
Published in Nature communications (21.01.2019)
Published in Nature communications (21.01.2019)
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Journal Article
Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
Owen, Bryn M, Mangelsdorf, David J, Kliewer, Steven A
Published in Trends in endocrinology and metabolism (01.01.2015)
Published in Trends in endocrinology and metabolism (01.01.2015)
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Journal Article
FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
Owen, Bryn M., Ding, Xunshan, Morgan, Donald A., Coate, Katie Colbert, Bookout, Angie L., Rahmouni, Kamal, Kliewer, Steven A., Mangelsdorf, David J.
Published in Cell metabolism (07.10.2014)
Published in Cell metabolism (07.10.2014)
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Journal Article
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
Potthoff, Matthew J, Kliewer, Steven A, Mangelsdorf, David J
Published in Genes & development (15.02.2012)
Published in Genes & development (15.02.2012)
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Journal Article
Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding
Markan, Kathleen R, Naber, Meghan C, Ameka, Magdalene K, Anderegg, Maxwell D, Mangelsdorf, David J, Kliewer, Steven A, Mohammadi, Moosa, Potthoff, Matthew J
Published in Diabetes (New York, N.Y.) (01.12.2014)
Published in Diabetes (New York, N.Y.) (01.12.2014)
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Journal Article
GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
Drube, J., Haider, R. S., Matthees, E. S. F., Reichel, M., Zeiner, J., Fritzwanker, S., Ziegler, C., Barz, S., Klement, L., Filor, J., Weitzel, V., Kliewer, A., Miess-Tanneberg, E., Kostenis, E., Schulz, S., Hoffmann, C.
Published in Nature communications (27.01.2022)
Published in Nature communications (27.01.2022)
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Journal Article
Fibroblast growth factor 21: from pharmacology to physiology
KLIEWER, Steven A, MANGELSDORF, David J
Published in The American journal of clinical nutrition (2010)
Published in The American journal of clinical nutrition (2010)
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Conference Proceeding
Journal Article
FGF21 Regulates Sweet and Alcohol Preference
Talukdar, Saswata, Owen, Bryn M., Song, Parkyong, Hernandez, Genaro, Zhang, Yuan, Zhou, Yingjiang, Scott, William T., Paratala, Bhavna, Turner, Tod, Smith, Andrew, Bernardo, Barbara, Müller, Christian P., Tang, Hao, Mangelsdorf, David J., Goodwin, Bryan, Kliewer, Steven A.
Published in Cell metabolism (09.02.2016)
Published in Cell metabolism (09.02.2016)
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Journal Article
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
Wei, Wei, Dutchak, Paul A, Wang, Xunde, Ding, Xunshan, Wang, Xueqian, Bookout, Angie L, Goetz, Regina, Mohammadi, Moosa, Gerard, Robert D, Dechow, Paul C, Mangelsdorf, David J, Kliewer, Steven A, Wan, Yihong
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
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Journal Article
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
Kir, Serkan, Beddow, Sara A., Samuel, Varman T., Miller, Paul, Previs, Stephen F., Suino-Powell, Kelly, Xu, H. Eric, Shulman, Gerald I., Kliewer, Steven A., Mangelsdorf, David J.
Published in Science (American Association for the Advancement of Science) (25.03.2011)
Published in Science (American Association for the Advancement of Science) (25.03.2011)
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Journal Article
Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21
Inagaki, Takeshi, Lin, Vicky Y., Goetz, Regina, Mohammadi, Moosa, Mangelsdorf, David J., Kliewer, Steven A.
Published in Cell metabolism (01.07.2008)
Published in Cell metabolism (01.07.2008)
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Journal Article
Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
Youm, Yun-Hee, Horvath, Tamas L., Mangelsdorf, David J., Kliewer, Steven A., Dixit, Vishwa Deep
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2016)
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Journal Article
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
Potthoff, Matthew J, Inagaki, Takeshi, Satapati, Santhosh, Ding, Xunshan, He, Tianteng, Goetz, Regina, Mohammadi, Moosa, Finck, Brian N, Mangelsdorf, David J, Kliewer, Steven A, Burgess, Shawn C
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2009)
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Journal Article
The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol
Song, Parkyong, Zechner, Christoph, Hernandez, Genaro, Cánovas, José, Xie, Yang, Sondhi, Varun, Wagner, Martin, Stadlbauer, Vanessa, Horvath, Angela, Leber, Bettina, Hu, Ming Chang, Moe, Orson W., Mangelsdorf, David J., Kliewer, Steven A.
Published in Cell metabolism (05.06.2018)
Published in Cell metabolism (05.06.2018)
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Journal Article
FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes
Abu-Odeh, Mohammad, Zhang, Yuan, Reilly, Shannon M., Ebadat, Nima, Keinan, Omer, Valentine, Joseph M., Hafezi-Bakhtiari, Maziar, Ashayer, Hadeel, Mamoun, Lana, Zhou, Xin, Zhang, Jin, Yu, Ruth T., Dai, Yang, Liddle, Christopher, Downes, Michael, Evans, Ronald M., Kliewer, Steven A., Mangelsdorf, David J., Saltiel, Alan R.
Published in Cell reports (Cambridge) (29.06.2021)
Published in Cell reports (Cambridge) (29.06.2021)
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Journal Article
Detection of FGF15 in Plasma by Stable Isotope Standards and Capture by Anti-peptide Antibodies and Targeted Mass Spectrometry
Katafuchi, Takeshi, Esterházy, Daria, Lemoff, Andrew, Ding, Xunshan, Sondhi, Varun, Kliewer, Steven A., Mirzaei, Hamid, Mangelsdorf, David J.
Published in Cell metabolism (02.06.2015)
Published in Cell metabolism (02.06.2015)
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Journal Article
Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid
Albarqi, Mennatallah M Y, Stoltzfus, Jonathan D, Pilgrim, Adeiye A, Nolan, Thomas J, Wang, Zhu, Kliewer, Steven A, Mangelsdorf, David J, Lok, James B
Published in PLoS pathogens (01.01.2016)
Published in PLoS pathogens (01.01.2016)
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Journal Article