Pre-existing technological core and roots for the CRISPR breakthrough
Magee, Christopher L, Kleyn, Patrick W, Monks, Brendan M, Betz, Ulrich, Basnet, Subarna
Published in PloS one (19.09.2018)
Published in PloS one (19.09.2018)
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Journal Article
Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation
Sharma, Shubh, Garfield, Alastair S, Shah, Bhavik, Kleyn, Patrick, Ichetovkin, Ilia, Moeller, Ida Hatoum, Mowrey, William R, Van der Ploeg, Lex H T
Published in Molecules (Basel, Switzerland) (16.05.2019)
Published in Molecules (Basel, Switzerland) (16.05.2019)
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Journal Article
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment
Lechner, Lara, Opitz, Robert, Silver, Matt J, Krabusch, Philipp M, Prentice, Andrew M, Field, Martha S, Stachelscheid, Harald, Leitão, Elsa, Schröder, Christopher, Fernandez Vallone, Valeria, Horsthemke, Bernhard, Jöckel, Karl-Heinz, Schmidt, Börge, Nöthen, Markus M, Hoffmann, Per, Herms, Stefan, Kleyn, Patrick W, Megges, Matthias, Blume-Peytavi, Ulrike, Weiss, Katja, Mai, Knut, Blankenstein, Oliver, Obermayer, Benedikt, Wiegand, Susanna, Kühnen, Peter
Published in Science translational medicine (19.07.2023)
Published in Science translational medicine (19.07.2023)
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Journal Article
Association Testing by DNA Pooling: An Effective Initial Screen
Bansal, Aruna, van den Boom, Dirk, Kammerer, Stefan, Honisch, Christiane, Adam, Gail, Cantor, Charles R., Kleyn, Patrick, Braun, Andi
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2002)
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Journal Article
Genetic Variation as a Guide to Drug Development
Kleyn, Patrick W., Vesell, Elliot S.
Published in Science (American Association for the Advancement of Science) (18.09.1998)
Published in Science (American Association for the Advancement of Science) (18.09.1998)
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Journal Article
Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort
WILSON, Scott G, ADAM, Gail, SAMBROOK, Philip N, KLEYN, Patrick W, SPECTOR, Tim D, LANGDOWN, Maria, RENELAND, Rikard, BRAUN, Andreas, ANDREW, Toby, SURDULESCU, Gabriela L, NORBERG, Maria, DUDBRIDGE, Frank, REED, Peter W
Published in European journal of human genetics : EJHG (01.03.2006)
Published in European journal of human genetics : EJHG (01.03.2006)
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Journal Article
Identification and functional analysis of novel human melanocortin-4 receptor variants
WEI GU, ZHIMING TU, FRANCO, L. S, BURN, P, YAGALOFF, K. A, NATHAN, J, HEYMSFIELD, S, ALBU, J, PI-SUNYER, F. X, ALLISON, D. B, KLEYN, P. W, KISSEBAH, A, DUPRAT, L, LEE, J, CHIN, W, MARUTI, S, DENG, N, FISHER, S. L
Published in Diabetes (New York, N.Y.) (01.03.1999)
Published in Diabetes (New York, N.Y.) (01.03.1999)
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Journal Article
Variants in Obesity-Related Genes in a Population With Early-Onset Obesity
Bromberg, Elliot, Norton, Rick, Kleyn, Patrick
Published in Obesity (Silver Spring, Md.) (01.11.2022)
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Published in Obesity (Silver Spring, Md.) (01.11.2022)
Journal Article
Frequency of BBS and AS Gene Variants in a Cohort With Early-Onset Obesity
Kleyn, Patrick, Bromberg, Elliot, Norton, Rick
Published in Obesity (Silver Spring, Md.) (01.11.2022)
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Published in Obesity (Silver Spring, Md.) (01.11.2022)
Journal Article
TULP1 mutation in two extended Dominican kindreds with autosomal recessive Retinitis pigmentosa
Banerjee, Poulabi, Kleyn, Patrick W, Knowles, James A, Lewis, Charles A, Ross, Barbara M, Parano, Enrico, Kovats, Steve G, Lee, John J, Penchaszadeh, Graciela K, Ott, Jürg, Jacobson, Samuel G, Gilliam, T. Conrad
Published in Nature genetics (01.02.1998)
Published in Nature genetics (01.02.1998)
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Journal Article
Uncovering Rare Obesity Genetic Testing Program: Utility of Genetic Testing in Adults With Obesity
Kleyn, Patrick, Sleiman, Patrick, Bromberg, Elliot, Norton, Rick
Published in Obesity (Silver Spring, Md.) (01.11.2022)
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Published in Obesity (Silver Spring, Md.) (01.11.2022)
Journal Article
Targeted Deletion of the tub Mouse Obesity Gene Reveals that tubby Is a Loss-of-Function Mutation
Stubdal, Hilde, Lynch, Catherine A., Moriarty, Ann, Fang, Qing, Chickering, Troy, Deeds, James D., Fairchild-Huntress, Victoria, Charlat, Olga, Dunmore, Judy H., Kleyn, Patrick, Huszar, Dennis, Kapeller, Rosana
Published in Molecular and Cellular Biology (01.02.2000)
Published in Molecular and Cellular Biology (01.02.2000)
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Journal Article
Frequency of MC4R Pathway Variants in a Large US Cohort of Patients With Severe Obesity
Bromberg, Elliot, Norton, Rick, Sleiman, Patrick, Hakonarson, Hakon, Bahl, Samira, Kleyn, Patrick
Published in Obesity (Silver Spring, Md.) (01.11.2022)
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Published in Obesity (Silver Spring, Md.) (01.11.2022)
Journal Article
Frequency of MC4R Pathway Variants in a Large US Cohort of Patients with Severe Obesity
Moeller, Ida Hatoum, Kleyn, Patrick, Sleiman, Patrick, Vaccaro, Courtney, Hakonarson, Hakon, Bahl, Samira, Antao, Tiago, Garfield, Alastair
Published in Obesity (Silver Spring, Md.) (01.12.2021)
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Published in Obesity (Silver Spring, Md.) (01.12.2021)
Journal Article
Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants
Shah, Bhavik P., Sleiman, Patrick M., Mc Donald, Jessica, Moeller, Ida H., Kleyn, Patrick
Published in Expert review of endocrinology & metabolism (04.03.2023)
Published in Expert review of endocrinology & metabolism (04.03.2023)
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Journal Article
Pre-existing Technological Core and Roots for the CRISPR Breakthrough
Magee, Christopher L, Kleyn, Patrick W, Monks, Brendan M, Betz, Ulrich, Basnet, Subarna
Published in bioRxiv (24.05.2018)
Published in bioRxiv (24.05.2018)
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Paper
Mapping of Human Microtubule-Associated Protein 1B in Proximity to the Spinal Muscular Atrophy Locus at 5q13
LIEN, L. L, BOYCE, F. M, KLEYN, P, BRZUSTOWICZ, L. M, MENNINGER, J, WARD, D. C, CONRAD GILLIAM, T, KUNKEL, L. M
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.1991)
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.1991)
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