Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
Bueno-Carrasco, María Teresa, Cuéllar, Jorge, Flydal, Marte I., Santiago, César, Kråkenes, Trond-André, Kleppe, Rune, López-Blanco, José R., Marcilla, Miguel, Teigen, Knut, Alvira, Sara, Chacón, Pablo, Martinez, Aurora, Valpuesta, José M.
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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Journal Article
DOPA Homeostasis by Dopamine: A Control-Theoretic View
Kleppe, Rune, Waheed, Qaiser, Ruoff, Peter
Published in International journal of molecular sciences (28.11.2021)
Published in International journal of molecular sciences (28.11.2021)
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Journal Article
The 14-3-3 proteins in regulation of cellular metabolism
Kleppe, Rune, Martinez, Aurora, Døskeland, Stein Ove, Haavik, Jan
Published in Seminars in cell & developmental biology (01.09.2011)
Published in Seminars in cell & developmental biology (01.09.2011)
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Journal Article
Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets
Kleppe, Rune, Jonassen, Inge, Døskeland, Stein Ove, Selheim, Frode
Published in International journal of molecular sciences (19.02.2018)
Published in International journal of molecular sciences (19.02.2018)
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Journal Article
Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action
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Journal Article
Book Review
In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins
Pakdaman, Yasaman, Sanchez-Guixé, Monica, Kleppe, Rune, Erdal, Sigrid, Bustad, Helene J, Bjørkhaug, Lise, Haugarvoll, Kristoffer, Tzoulis, Charalampos, Heimdal, Ketil, Knappskog, Per M, Johansson, Stefan, Aukrust, Ingvild
Published in Bioscience reports (30.04.2017)
Published in Bioscience reports (30.04.2017)
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Journal Article
Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3
Herfindal, Lars, Krakstad, Camilla, Myhren, Lene, Hagland, Hanne, Kopperud, Reidun, Teigen, Knut, Schwede, Frank, Kleppe, Rune, Døskeland, Stein Ove
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Journal Article
Three-way Interaction between 14-3-3 Proteins, the N-terminal Region of Tyrosine Hydroxylase, and Negatively Charged Membranes
Halskau, Øyvind, Ying, Ming, Baumann, Anne, Kleppe, Rune, Rodriguez-Larrea, David, Almås, Bjørg, Haavik, Jan, Martinez, Aurora
Published in The Journal of biological chemistry (20.11.2009)
Published in The Journal of biological chemistry (20.11.2009)
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Journal Article
Nostocyclopeptide-M1: A Potent, Nontoxic Inhibitor of the Hepatocyte Drug Transporters OATP1B3 and OATP1B1
Herfindal, Lars, Myhren, Lene, Kleppe, Rune, Krakstad, Camilla, Selheim, Frode, Jokela, Jouni, Sivonen, Kaarina, Døskeland, Stein O
Published in Molecular pharmaceutics (04.04.2011)
Published in Molecular pharmaceutics (04.04.2011)
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Journal Article
Regulation of tyrosine hydroxylase by stress‐activated protein kinases
Toska, Karen, Kleppe, Rune, Armstrong, Christopher G., Morrice, Nick A., Cohen, Philip, Haavik, Jan
Published in Journal of neurochemistry (01.11.2002)
Published in Journal of neurochemistry (01.11.2002)
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Journal Article
Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease
Waløen, Kai, Kleppe, Rune, Martinez, Aurora, Haavik, Jan
Published in Expert opinion on therapeutic targets (01.02.2017)
Published in Expert opinion on therapeutic targets (01.02.2017)
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Journal Article
The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders
Szigetvari, Peter D, Patil, Sudarshan, Birkeland, Even, Kleppe, Rune, Haavik, Jan
Published in Neurochemistry international (01.12.2023)
Published in Neurochemistry international (01.12.2023)
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Journal Article
Urea-induced Denaturation of Human Phenylalanine Hydroxylase
Kleppe, Rune, Uhlemann, Kathrin, Knappskog, Per M., Haavik, Jan
Published in The Journal of biological chemistry (19.11.1999)
Published in The Journal of biological chemistry (19.11.1999)
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Journal Article
Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE
Jacobsen, Kaya K., Kleppe, Rune, Johansson, Stefan, Zayats, Tetyana, Haavik, Jan
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01.09.2015)
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01.09.2015)
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Journal Article
Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules
Jorge-Finnigan, Ana, Kleppe, Rune, Jung-KC, Kunwar, Ying, Ming, Marie, Michael, Rios-Mondragon, Ivan, Salvatore, Michael F., Saraste, Jaakko, Martinez, Aurora
Published in The Journal of biological chemistry (25.08.2017)
Published in The Journal of biological chemistry (25.08.2017)
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Journal Article