Tumor Mutational Burden as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors: A Review of Current Evidence
Klempner, Samuel J., Fabrizio, David, Bane, Shalmali, Reinhart, Marcia, Peoples, Tim, Ali, Siraj M., Sokol, Ethan S., Frampton, Garrett, Schrock, Alexa B., Anhorn, Rachel, Reddy, Prasanth
Published in The oncologist (Dayton, Ohio) (01.01.2020)
Published in The oncologist (Dayton, Ohio) (01.01.2020)
Get full text
Journal Article
Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation
Tanaka, Noritaka, Lin, Jessica J., Li, Chendi, Ryan, Meagan B., Zhang, Junbing, Kiedrowski, Lesli A., Michel, Alexa G., Syed, Mohammed U., Fella, Katerina A., Sakhi, Mustafa, Baiev, Islam, Juric, Dejan, Gainor, Justin F., Klempner, Samuel J., Lennerz, Jochen K., Siravegna, Giulia, Bar-Peled, Liron, Hata, Aaron N., Heist, Rebecca S., Corcoran, Ryan B.
Published in Cancer discovery (01.08.2021)
Published in Cancer discovery (01.08.2021)
Get full text
Journal Article
Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C
Yaeger, Rona, Weiss, Jared, Pelster, Meredith S., Spira, Alexander I., Barve, Minal, Ou, Sai-Hong I., Leal, Ticiana A., Bekaii-Saab, Tanios S., Paweletz, Cloud P., Heavey, Grace A., Christensen, James G., Velastegui, Karen, Kheoh, Thian, Der-Torossian, Hirak, Klempner, Samuel J.
Published in The New England journal of medicine (05.01.2023)
Published in The New England journal of medicine (05.01.2023)
Get full text
Journal Article
A Space-Time Continuum for Immunotherapy Biomarkers in Gastroesophageal Cancer?
Klempner, Samuel J, Upadhyay, Vivek, Chao, Joseph
Published in Clinical cancer research (15.12.2020)
Published in Clinical cancer research (15.12.2020)
Get full text
Journal Article
Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability-High Gastric Cancer
Kwon, Minsuk, An, Minae, Klempner, Samuel J, Lee, Hyuk, Kim, Kyoung-Mee, Sa, Jason K, Cho, Hee Jin, Hong, Jung Yong, Lee, Taehyang, Min, Yang Won, Kim, Tae Jun, Min, Byung-Hoon, Park, Woong-Yang, Kang, Won Ki, Kim, Kyu-Tae, Kim, Seung Tae, Lee, Jeeyun
Published in Cancer discovery (01.09.2021)
Published in Cancer discovery (01.09.2021)
Get full text
Journal Article
Real-Time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations That Might Be Targeted With Existing Drugs or Used as Biomarkers
Singhi, Aatur D., George, Ben, Greenbowe, Joel R., Chung, Jon, Suh, James, Maitra, Anirban, Klempner, Samuel J., Hendifar, Andrew, Milind, Javle M., Golan, Talia, Brand, Randall E., Zureikat, Amer H., Roy, Somak, Schrock, Alexa B., Miller, Vincent A., Ross, Jeffrey S., Ali, Siraj M., Bahary, Nathan
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2019)
Get full text
Journal Article
Progress and challenges in HER2-positive gastroesophageal adenocarcinoma
Zhao, Dan, Klempner, Samuel J, Chao, Joseph
Published in Journal of hematology and oncology (17.05.2019)
Published in Journal of hematology and oncology (17.05.2019)
Get full text
Journal Article
Targeted therapy for gastric cancer: Molecular pathways and ongoing investigations
Yang, Wei, Raufi, Alexander, Klempner, Samuel J.
Published in Biochimica et biophysica acta (01.08.2014)
Published in Biochimica et biophysica acta (01.08.2014)
Get full text
Journal Article
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial
Tian, Jun, Chen, Jonathan H, Chao, Sherry X, Pelka, Karin, Giannakis, Marios, Hess, Julian, Burke, Kelly, Jorgji, Vjola, Sindurakar, Princy, Braverman, Jonathan, Mehta, Arnav, Oka, Tomonori, Huang, Mei, Lieb, David, Spurrell, Maxwell, Allen, Jill N, Abrams, Thomas A, Clark, Jeffrey W, Enzinger, Andrea C, Enzinger, Peter C, Klempner, Samuel J, McCleary, Nadine J, Meyerhardt, Jeffrey A, Ryan, David P, Yurgelun, Matthew B, Kanter, Katie, Van Seventer, Emily E, Baiev, Islam, Chi, Gary, Jarnagin, Joy, Bradford, William B, Wong, Edmond, Michel, Alexa G, Fetter, Isobel J, Siravegna, Giulia, Gemma, Angelo J, Sharpe, Arlene, Demehri, Shadmehr, Leary, Rebecca, Campbell, Catarina D, Yilmaz, Omer, Getz, Gad A, Parikh, Aparna R, Hacohen, Nir, Corcoran, Ryan B
Published in Nature medicine (01.02.2023)
Published in Nature medicine (01.02.2023)
Get full text
Journal Article
Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Parikh, Aparna R, Van Seventer, Emily E, Siravegna, Giulia, Hartwig, Anna V, Jaimovich, Ariel, He, Yupeng, Kanter, Katie, Fish, Madeleine G, Fosbenner, Kathryn D, Miao, Benchun, Phillips, Susannah, Carmichael, John H, Sharma, Nihaarika, Jarnagin, Joy, Baiev, Islam, Shah, Yojan S, Fetter, Isobel J, Shahzade, Heather A, Allen, Jill N, Blaszkowsky, Lawrence S, Clark, Jeffrey W, Dubois, Jon S, Franses, Joseph W, Giantonio, Bruce J, Goyal, Lipika, Klempner, Samuel J, Nipp, Ryan D, Roeland, Eric J, Ryan, David P, Weekes, Colin D, Wo, Jennifer Y, Hong, Theodore S, Bordeianou, Liliana, Ferrone, Cristina R, Qadan, Motaz, Kunitake, Hiroko, Berger, David, Ricciardi, Rocco, Cusack, James C, Raymond, Victoria M, Talasaz, AmirAli, Boland, Genevieve M, Corcoran, Ryan B
Published in Clinical cancer research (15.10.2021)
Published in Clinical cancer research (15.10.2021)
Get full text
Journal Article
Receptor Tyrosine Kinase Fusions and BRAF Kinase Fusions are Rare but Actionable Resistance Mechanisms to EGFR Tyrosine Kinase Inhibitors
Schrock, Alexa B., Zhu, Viola W., Hsieh, Wen-Son, Madison, Russell, Creelan, Benjamin, Silberberg, Jeffrey, Costin, Dan, Bharne, Anjali, Bonta, Ioana, Bosemani, Thangavijayan, Nikolinakos, Petros, Ross, Jeffrey S., Miller, Vincent A., Ali, Siraj M., Klempner, Samuel J., Ou, Sai-Hong Ignatius
Published in Journal of thoracic oncology (01.09.2018)
Published in Journal of thoracic oncology (01.09.2018)
Get full text
Journal Article
Early Tumor-Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer
Kim, Ryul, An, Minae, Lee, Hyuk, Mehta, Arnav, Heo, You Jeong, Kim, Kyoung-Mee, Lee, Song-Yi, Moon, Jeonghyeon, Kim, Seung Tae, Min, Byung-Hoon, Kim, Tae Jun, Rha, Sun Young, Kang, Won Ki, Park, Woong-Yang, Klempner, Samuel J, Lee, Jeeyun
Published in Cancer discovery (01.04.2022)
Published in Cancer discovery (01.04.2022)
Get full text
Journal Article
Prevalence of established and emerging biomarkers of immune checkpoint inhibitor response in advanced hepatocellular carcinoma
Ang, Celina, Klempner, Samuel J, Ali, Siraj M, Madison, Russell, Ross, Jeffrey S, Severson, Eric A, Fabrizio, David, Goodman, Aaron, Kurzrock, Razelle, Suh, James, Millis, Sherri Z
Published in Oncotarget (18.06.2019)
Published in Oncotarget (18.06.2019)
Get full text
Journal Article
A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients with Locally Advanced or Metastatic Cancers
Diab, Adi, Hamid, Omid, Thompson, John A, Ros, Willeke, Eskens, Ferry A L M, Doi, Toshihiko, Hu-Lieskovan, Siwen, Klempner, Samuel J, Ganguly, Bishu, Fleener, Catherine, Wang, Xiao, Joh, Tenshang, Liao, Ken, Salek-Ardakani, Shahram, Taylor, Carrie Turich, Chou, Jeffrey, El-Khoueiry, Anthony B
Published in Clinical cancer research (01.01.2022)
Published in Clinical cancer research (01.01.2022)
Get full text
Journal Article
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma
Chen, Li, Huang, Moli, Plummer, Jasmine, Pan, Jian, Jiang, Yan Yi, Yang, Qian, Silva, Tiago Chedraoui, Gull, Nicole, Chen, Stephanie, Ding, Ling Wen, An, Omer, Yang, Henry, Cheng, Yulan, Said, Jonathan W, Doan, Ngan, Dinjens, Winand NM, Waters, Kevin M, Tuli, Richard, Gayther, Simon A, Klempner, Samuel J, Berman, Benjamin P, Meltzer, Stephen J, Lin, De-Chen, Koeffler, H Phillip
Published in Gut (01.04.2020)
Published in Gut (01.04.2020)
Get full text
Journal Article
Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy
Parikh, Aparna R., He, Yuting, Hong, Ted S., Corcoran, Ryan B., Clark, Jeff W., Ryan, David P., Zou, Lee, Ting, David T., Catenacci, Daniel V., Chao, Joseph, Fakih, Marwan, Klempner, Samuel J., Ross, Jeffrey S., Frampton, Garrett M., Miller, Vincent A., Ali, Siraj M., Schrock, Alexa B.
Published in The oncologist (Dayton, Ohio) (01.10.2019)
Published in The oncologist (Dayton, Ohio) (01.10.2019)
Get full text
Journal Article