Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo
Guendisch, Ulf, Weiss, Jessica, Ecoeur, Florence, Riker, Julia Christina, Kaupmann, Klemens, Kallen, Joerg, Hintermann, Samuel, Orain, David, Dawson, Janet, Billich, Andreas, Guntermann, Christine
Published in PloS one (20.11.2017)
Published in PloS one (20.11.2017)
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Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses
Ecoeur, Florence, Weiss, Jessica, Kaupmann, Klemens, Hintermann, Samuel, Orain, David, Guntermann, Christine
Published in Frontiers in immunology (26.03.2019)
Published in Frontiers in immunology (26.03.2019)
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Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence
Liechti, Matthias E, Lhuillier, Loic, Kaupmann, Klemens, Markou, Athina
Published in The Journal of neuroscience (22.08.2007)
Published in The Journal of neuroscience (22.08.2007)
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Blocking Metabotropic Glutamate Receptor Subtype 7 (mGlu7) via the Venus Flytrap Domain (VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior
Gee, Christine E., Peterlik, Daniel, Neuhäuser, Christoph, Bouhelal, Rochdi, Kaupmann, Klemens, Laue, Grit, Uschold-Schmidt, Nicole, Feuerbach, Dominik, Zimmermann, Kaspar, Ofner, Silvio, Cryan, John F., van der Putten, Herman, Fendt, Markus, Vranesic, Ivo, Glatthar, Ralf, Flor, Peter J.
Published in The Journal of biological chemistry (18.04.2014)
Published in The Journal of biological chemistry (18.04.2014)
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Genetic and pharmacological evidence of a role for GABAB receptors in the modulation of anxiety- and antidepressant-like behavior
MOMBEREAU, Cedric, KAUPMANN, Klemens, FROESTL, Wolfgang, SANSIG, Gilles, VAN DER PUTTEN, Herman, CRYAN, John F
Published in Neuropsychopharmacology (New York, N.Y.) (01.06.2004)
Published in Neuropsychopharmacology (New York, N.Y.) (01.06.2004)
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Positive Modulation of GABAB Receptors Decreased Nicotine Self-Administration and Counteracted Nicotine-Induced Enhancement of Brain Reward Function in Rats
Paterson, Neil E., Vlachou, Styliani, Guery, Sebastien, Kaupmann, Klemens, Froestl, Wolfgang, Markou, Athina
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)
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Differential compartmentalization and distinct functions of GABAB receptor variants
Vigot, Réjan, Barbieri, Samuel, Bräuner-Osborne, Hans, Turecek, Rostislav, Shigemoto, Ryuichi, Zhang, Yan-Ping, Luján, Rafael, Jacobson, Laura H, Biermann, Barbara, Fritschy, Jean-Marc, Vacher, Claire-Marie, Müller, Matthias, Sansig, Gilles, Guetg, Nicole, Cryan, John F, Kaupmann, Klemens, Gassmann, Martin, Oertner, Thomas G, Bettler, Bernhard
Published in Neuron (Cambridge, Mass.) (18.05.2006)
Published in Neuron (Cambridge, Mass.) (18.05.2006)
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Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition
Cassasus, Guillaume, Barbieri, Samuel, van der Putten, Herman, Humeau, Yann, Ciocchi, Stephane, Shaban, Hamdy, Kaupmann, Klemens, Bettler, Bernhard, Lüthi, Andreas, Herry, Cyril, Shigemoto, Ryuichi
Published in Nature neuroscience (01.08.2006)
Published in Nature neuroscience (01.08.2006)
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Behavioral Characterization of the Novel GABAB Receptor-Positive Modulator GS39783 (N,Nâ²-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines
Cryan, John F, Kelly, Peter H, Chaperon, Frederique, Gentsch, Conrad, Mombereau, Cedric, Lingenhoehl, Kurt, Froestl, Wolfgang, Bettler, Bernhard, Kaupmann, Klemens, Spooren, Will P J M
Published in The Journal of pharmacology and experimental therapeutics (01.09.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2004)
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Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate
Krumova, Petranka, Reyniers, Lauran, Meyer, Marc, Lobbestael, Evy, Stauffer, Daniela, Gerrits, Bertran, Muller, Lionel, Hoving, Sjouke, Kaupmann, Klemens, Voshol, Johannes, Fabbro, Doriano, Bauer, Andreas, Rovelli, Giorgio, Taymans, Jean-Marc, Bouwmeester, Tewis, Baekelandt, Veerle
Published in The FASEB journal (01.07.2015)
Published in The FASEB journal (01.07.2015)
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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
HERZIG, Martin C, KOLLY, Carine, SCHNELL, Christian R, MUELLER, Matthias, KINZEL, Bernd, GREVOT, Armelle, BOLOGNANI, Federico, STIRN, Martina, KUHN, Rainer R, KAUPMANN, Klemens, VAN DER PUTTEN, P. Herman, ROVELLI, Giorgio, PERSOHN, Elke, SHIMSHEK, Derya R, THEIL, Diethilde, SCHWEIZER, Tatjana, HAFNER, Thomas, STEMMELEN, Christine, TROXLER, Thomas J, SCHMID, Peter, DANNER, Simone
Published in Human molecular genetics (01.11.2011)
Published in Human molecular genetics (01.11.2011)
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Behavioral evaluation of mice deficient in GABAB(1) receptor isoforms in tests of unconditioned anxiety
JACOBSON, Laura H, BETTLER, Bernhard, KAUPMANN, Klemens, CRYAN, John F
Published in Psychopharmacologia (01.03.2007)
Published in Psychopharmacologia (01.03.2007)
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Journal Article
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations
Guntermann, Christine, Piaia, Alessandro, Hamel, Marie-Laure, Theil, Diethilde, Rubic-Schneider, Tina, Del Rio-Espinola, Alberto, Dong, Linda, Billich, Andreas, Kaupmann, Klemens, Dawson, Janet, Hoegenauer, Klemens, Orain, David, Hintermann, Samuel, Stringer, Rowan, Patel, Dhavalkumar D, Doelemeyer, Arno, Deurinck, Mark, Schümann, Jens
Published in JCI insight (09.03.2017)
Published in JCI insight (09.03.2017)
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The Sushi Domains of Secreted GABAB1 Isoforms Selectively Impair GABAB Heteroreceptor Function
Tiao, Jim Y., Bradaia, Amyaouch, Biermann, Barbara, Kaupmann, Klemens, Metz, Michaela, Haller, Corinne, Rolink, Antonius G., Pless, Elin, Barlow, Paul N., Gassmann, Martin, Bettler, Bernhard
Published in The Journal of biological chemistry (07.11.2008)
Published in The Journal of biological chemistry (07.11.2008)
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Journal Article
GABAB(1) Receptor Subunit Isoforms Exert a Differential Influence on Baseline but Not GABAB Receptor Agonist-Induced Changes in Mice
Laura H. Jacobson, Bernhard Bettler, Klemens Kaupmann, John F. Cryan
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Subtype-selective Interaction with the Transcription Factor CCAAT/Enhancer-binding Protein (C/EBP) Homologous Protein (CHOP) Regulates Cell Surface Expression of GABAB Receptors
Sauter, Kathrin, Grampp, Thomas, Fritschy, Jean-Marc, Kaupmann, Klemens, Bettler, Bernhard, Mohler, Hanns, Benke, Dietmar
Published in The Journal of biological chemistry (30.09.2005)
Published in The Journal of biological chemistry (30.09.2005)
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Human γ -aminobutyric Acid Type B Receptors are Differentially Expressed and Regulate Inwardly Rectifying K+Channels
Kaupmann, Klemens, Schuler, Valerie, Mosbacher, Johannes, Bischoff, Serge, Bittiger, Helmut, Heid, Jakob, Froestl, Wolfgang, Leonhard, Sabine, Pfaff, Torsten, Karschin, Andreas, Bettler, Bernhard
Published in Proceedings of the National Academy of Sciences - PNAS (08.12.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (08.12.1998)
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Don't worry ‘B’ happy!: a role for GABAB receptors in anxiety and depression
Cryan, John F., Kaupmann, Klemens
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2005)
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2005)
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